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Increased airway responsiveness to acetaldehyde in asthmatic subjects with alcohol-induced bronchoconstriction.
Eur Respir J. 1999 Jul; 14(1):19-22.ER

Abstract

Bronchial responsiveness to acetaldehyde, a main factor in alcohol-induced bronchoconstriction, and methacholine were compared between 10 subjects with alcohol-induced bronchoconstriction and 16 asthmatic subjects without alcohol sensitivity. In the alcohol-sensitive group, the geometric mean (geometric SEM (GSEM)) of the provocative concentration of methacholine (PC20,meth) and acetaldehyde (PC20,acet) causing a 20% fall in forced expiratory volume in one second were 0.947 mg x mL(-1) (GSEM 0.139) and 21.0 mg x mL(-1) (GSEM 0.112), respectively, which were not significantly different from those in the nonalcohol-sensitive group, which were 0.634 mg x mL(-1) (GSEM 0.115) and 31.7 mg x mL(-1) (GSEM 0.077), respectively. The ratio of airway responsiveness to acetaldehyde relative to methacholine (log PC20,acet/PC20,meth) was 1.345+/-0.093 (mean+/-SEM) in the alcohol-sensitive group, which was significantly different from the value of 1.699+/-0.059 in the nonalcohol-sensitive group (p=0.0025). A significant correlation was observed between PC20,meth and PC20,acet in both the alcohol-sensitive group (r=-0.742, p=0.0115) and nonsensitive group (r=0.882, p<0.0001). In conclusion, the airways of asthmatic subjects with alcohol-induced bronchoconstriction have a selective hyperresponsiveness to acetaldehyde.

Authors+Show Affiliations

The Third Dept of Internal Medicine, Kanazawa University School of Medicine, Takara-machi, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10489823

Citation

Fujimura, M, et al. "Increased Airway Responsiveness to Acetaldehyde in Asthmatic Subjects With Alcohol-induced Bronchoconstriction." The European Respiratory Journal, vol. 14, no. 1, 1999, pp. 19-22.
Fujimura M, Myou S, Kamio Y, et al. Increased airway responsiveness to acetaldehyde in asthmatic subjects with alcohol-induced bronchoconstriction. Eur Respir J. 1999;14(1):19-22.
Fujimura, M., Myou, S., Kamio, Y., Ishiura, Y., Iwasa, K., Hashimoto, T., & Matsuda, T. (1999). Increased airway responsiveness to acetaldehyde in asthmatic subjects with alcohol-induced bronchoconstriction. The European Respiratory Journal, 14(1), 19-22.
Fujimura M, et al. Increased Airway Responsiveness to Acetaldehyde in Asthmatic Subjects With Alcohol-induced Bronchoconstriction. Eur Respir J. 1999;14(1):19-22. PubMed PMID: 10489823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased airway responsiveness to acetaldehyde in asthmatic subjects with alcohol-induced bronchoconstriction. AU - Fujimura,M, AU - Myou,S, AU - Kamio,Y, AU - Ishiura,Y, AU - Iwasa,K, AU - Hashimoto,T, AU - Matsuda,T, PY - 1999/9/18/pubmed PY - 1999/9/18/medline PY - 1999/9/18/entrez SP - 19 EP - 22 JF - The European respiratory journal JO - Eur Respir J VL - 14 IS - 1 N2 - Bronchial responsiveness to acetaldehyde, a main factor in alcohol-induced bronchoconstriction, and methacholine were compared between 10 subjects with alcohol-induced bronchoconstriction and 16 asthmatic subjects without alcohol sensitivity. In the alcohol-sensitive group, the geometric mean (geometric SEM (GSEM)) of the provocative concentration of methacholine (PC20,meth) and acetaldehyde (PC20,acet) causing a 20% fall in forced expiratory volume in one second were 0.947 mg x mL(-1) (GSEM 0.139) and 21.0 mg x mL(-1) (GSEM 0.112), respectively, which were not significantly different from those in the nonalcohol-sensitive group, which were 0.634 mg x mL(-1) (GSEM 0.115) and 31.7 mg x mL(-1) (GSEM 0.077), respectively. The ratio of airway responsiveness to acetaldehyde relative to methacholine (log PC20,acet/PC20,meth) was 1.345+/-0.093 (mean+/-SEM) in the alcohol-sensitive group, which was significantly different from the value of 1.699+/-0.059 in the nonalcohol-sensitive group (p=0.0025). A significant correlation was observed between PC20,meth and PC20,acet in both the alcohol-sensitive group (r=-0.742, p=0.0115) and nonsensitive group (r=0.882, p<0.0001). In conclusion, the airways of asthmatic subjects with alcohol-induced bronchoconstriction have a selective hyperresponsiveness to acetaldehyde. SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/10489823/Increased_airway_responsiveness_to_acetaldehyde_in_asthmatic_subjects_with_alcohol_induced_bronchoconstriction_ L2 - http://erj.ersjournals.com/cgi/pmidlookup?view=long&amp;pmid=10489823 DB - PRIME DP - Unbound Medicine ER -