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Breast cancer and oral contraceptive use in Asian-American women.
Am J Epidemiol. 1999 Sep 15; 150(6):561-7.AJ

Abstract

Breast cancer incidence has historically been 4-7 times higher in the United States than in Asia. A previous study by the authors in Asian-American women demonstrated a substantial increase in breast cancer risk in women who migrated from Asia to the United States, with the risk almost doubling during the first decade after migration. Increased use of oral contraceptives soon after migration to the United States could possibly explain this rapid rise in risk. In a population-based case-control study of Chinese, Filipino, and Japanese-American women, aged 20-55 years, who lived in San Francisco-Oakland, California; Los Angeles, California; and Oahu, Hawaii during 1983-1987, 597 cases (70% of those eligible) and 966 controls (75%) were interviewed. Controls were matched to cases on age, ethnicity, and area of residence. Oral contraceptive (OC) use increased with time since migration; 15.0% of Asian-born women who had been in the West <8 years, 33.4% of Asian-born women who had been in the West > or =8 years, and 49.6% of Asian women born in the West had ever used OCs. However, duration of OC use (adjusted for age, ethnicity, study area, years since migration, education, family history of breast cancer and age at first full-term birth) was not associated with increased risk of breast cancer. Moreover, neither OC use before age 25 years nor before first full-term birth was associated with increased risk. Results were unchanged when restricted to women under age 45 years or under age 40 years. After adjustment for duration of OC use, women who had been in the United States > or =8 years were still at almost twice the risk of breast cancer compared with women who had been in the United States 2-7 years. This study suggests that OC use cannot explain the elevated risk observed in Asian women who migrated to the United States > or =7 years ago.

Authors+Show Affiliations

Department of Preventive Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles 90033-0800, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

10489994

Citation

Ursin, G, et al. "Breast Cancer and Oral Contraceptive Use in Asian-American Women." American Journal of Epidemiology, vol. 150, no. 6, 1999, pp. 561-7.
Ursin G, Wu AH, Hoover RN, et al. Breast cancer and oral contraceptive use in Asian-American women. Am J Epidemiol. 1999;150(6):561-7.
Ursin, G., Wu, A. H., Hoover, R. N., West, D. W., Nomura, A. M., Kolonel, L. N., Pike, M. C., & Ziegler, R. G. (1999). Breast cancer and oral contraceptive use in Asian-American women. American Journal of Epidemiology, 150(6), 561-7.
Ursin G, et al. Breast Cancer and Oral Contraceptive Use in Asian-American Women. Am J Epidemiol. 1999 Sep 15;150(6):561-7. PubMed PMID: 10489994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast cancer and oral contraceptive use in Asian-American women. AU - Ursin,G, AU - Wu,A H, AU - Hoover,R N, AU - West,D W, AU - Nomura,A M, AU - Kolonel,L N, AU - Pike,M C, AU - Ziegler,R G, PY - 1999/9/18/pubmed PY - 1999/9/18/medline PY - 1999/9/18/entrez KW - Americas KW - Asians--women KW - Biology KW - Breast Cancer KW - California KW - Cancer KW - Case Control Studies KW - Contraception KW - Contraceptive Methods KW - Cultural Background KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Ethnic Groups KW - Family Planning KW - Hawaii KW - Immigrants--women KW - Migrants KW - Migration KW - Neoplasms KW - North America KW - Northern America KW - Oral Contraceptives KW - Population KW - Population Characteristics KW - Population Dynamics KW - Research Methodology KW - Research Report KW - Risk Factors KW - Studies KW - United States KW - Women SP - 561 EP - 7 JF - American journal of epidemiology JO - Am J Epidemiol VL - 150 IS - 6 N2 - Breast cancer incidence has historically been 4-7 times higher in the United States than in Asia. A previous study by the authors in Asian-American women demonstrated a substantial increase in breast cancer risk in women who migrated from Asia to the United States, with the risk almost doubling during the first decade after migration. Increased use of oral contraceptives soon after migration to the United States could possibly explain this rapid rise in risk. In a population-based case-control study of Chinese, Filipino, and Japanese-American women, aged 20-55 years, who lived in San Francisco-Oakland, California; Los Angeles, California; and Oahu, Hawaii during 1983-1987, 597 cases (70% of those eligible) and 966 controls (75%) were interviewed. Controls were matched to cases on age, ethnicity, and area of residence. Oral contraceptive (OC) use increased with time since migration; 15.0% of Asian-born women who had been in the West <8 years, 33.4% of Asian-born women who had been in the West > or =8 years, and 49.6% of Asian women born in the West had ever used OCs. However, duration of OC use (adjusted for age, ethnicity, study area, years since migration, education, family history of breast cancer and age at first full-term birth) was not associated with increased risk of breast cancer. Moreover, neither OC use before age 25 years nor before first full-term birth was associated with increased risk. Results were unchanged when restricted to women under age 45 years or under age 40 years. After adjustment for duration of OC use, women who had been in the United States > or =8 years were still at almost twice the risk of breast cancer compared with women who had been in the United States 2-7 years. This study suggests that OC use cannot explain the elevated risk observed in Asian women who migrated to the United States > or =7 years ago. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/10489994/Breast_cancer_and_oral_contraceptive_use_in_Asian_American_women_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a010053 DB - PRIME DP - Unbound Medicine ER -