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Sebum rheology evaluated by two methods in vivo. Split-face study of the effect of a cosmetic formulation.
Eur J Dermatol 1999; 9(6):455-7EJ

Abstract

Modulation of the rheological characteristics of sebum at the surface of the skin might represent a valuable strategy for the treatment of seborrhea. In this field, only a small number of studies have addressed sebum diffusion within the stratum corneum. In an open, split-face study conducted on 20 men, we measured the sebosuppressive effect of Effidrate cream which is based on a glycerol alkyl-ether. Measurements were made in the morning at three-week intervals for a total period of 3 months. Sebum casual levels and sebum excretion rates were measured using a SM810 Sebumeter. Lipid-absorbent Sebutape was also used to collect all the sebum released from infundibular reservoirs over a four-hour period. Clinical assessments were relatively uninformative but the photometric measurements showed that Effidrate cream had a sebosuppressive action. The underlying biological mechanism remains unclear but a hypothesis based on enhanced sebum absorption by the stratum corneum is discussed.

Authors+Show Affiliations

Centre de Recherche SSTC belge 5596, Service de Dermatopathologie, Institut de Pathologie, CHU du Sart Tilman, B-4000 Liège, Belgique.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

10491502

Citation

Piérard-Franchimont, C, et al. "Sebum Rheology Evaluated By Two Methods in Vivo. Split-face Study of the Effect of a Cosmetic Formulation." European Journal of Dermatology : EJD, vol. 9, no. 6, 1999, pp. 455-7.
Piérard-Franchimont C, Martalo O, Richard A, et al. Sebum rheology evaluated by two methods in vivo. Split-face study of the effect of a cosmetic formulation. Eur J Dermatol. 1999;9(6):455-7.
Piérard-Franchimont, C., Martalo, O., Richard, A., Rougier, A., & Piérard, G. E. (1999). Sebum rheology evaluated by two methods in vivo. Split-face study of the effect of a cosmetic formulation. European Journal of Dermatology : EJD, 9(6), pp. 455-7.
Piérard-Franchimont C, et al. Sebum Rheology Evaluated By Two Methods in Vivo. Split-face Study of the Effect of a Cosmetic Formulation. Eur J Dermatol. 1999;9(6):455-7. PubMed PMID: 10491502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sebum rheology evaluated by two methods in vivo. Split-face study of the effect of a cosmetic formulation. AU - Piérard-Franchimont,C, AU - Martalo,O, AU - Richard,A, AU - Rougier,A, AU - Piérard,G E, PY - 1999/9/24/pubmed PY - 1999/9/24/medline PY - 1999/9/24/entrez SP - 455 EP - 7 JF - European journal of dermatology : EJD JO - Eur J Dermatol VL - 9 IS - 6 N2 - Modulation of the rheological characteristics of sebum at the surface of the skin might represent a valuable strategy for the treatment of seborrhea. In this field, only a small number of studies have addressed sebum diffusion within the stratum corneum. In an open, split-face study conducted on 20 men, we measured the sebosuppressive effect of Effidrate cream which is based on a glycerol alkyl-ether. Measurements were made in the morning at three-week intervals for a total period of 3 months. Sebum casual levels and sebum excretion rates were measured using a SM810 Sebumeter. Lipid-absorbent Sebutape was also used to collect all the sebum released from infundibular reservoirs over a four-hour period. Clinical assessments were relatively uninformative but the photometric measurements showed that Effidrate cream had a sebosuppressive action. The underlying biological mechanism remains unclear but a hypothesis based on enhanced sebum absorption by the stratum corneum is discussed. SN - 1167-1122 UR - https://www.unboundmedicine.com/medline/citation/10491502/Sebum_rheology_evaluated_by_two_methods_in_vivo__Split_face_study_of_the_effect_of_a_cosmetic_formulation_ L2 - https://medlineplus.gov/cosmetics.html DB - PRIME DP - Unbound Medicine ER -