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Association of energy and fat intake with prostate carcinoma risk: results from The Netherlands Cohort Study.
Cancer. 1999 Sep 15; 86(6):1019-27.C

Abstract

BACKGROUND

The roles of energy and fat intake as risk factors for prostate carcinoma are still questionable. Therefore, these factors were evaluated in the Netherlands Cohort Study described in this article.

METHODS

The cohort study consisted of 58,279 men ages 55-69 years at baseline in 1986. After 6.3 years of follow-up, 642 incident prostate carcinoma cases were available for analysis. Intake of energy, fat, and separate fatty acids were measured by means of a self-administered questionnaire; fat intake was adjusted for energy by regression analysis. The case-cohort method was used to calculate rate ratios (RRs). Analyses were conducted for all prostate carcinoma cases together as well as for case subgroups (latent vs. nonlatent and localized vs. advanced).

RESULTS

No associations were found in multivariate analyses between prostate carcinoma and intake of energy, total fat, total saturated fatty acids, or total trans unsaturated fatty acids (RR highest vs. lowest quintile: 0.99, 1.10, 1.19, and 0.99, respectively). Oleic acid intake showed a nonsignificant positive association (RR = 1.38, 95% CI: 0.88-2.19). Positive associations were also observed for intake of oleic acid in subgroup analyses. Linoleic (RR = 0.78, 95% CI: 0. 56-1.09) and linolenic (RR = 0.76, 95% CI: 0.66-1.04) acid intake were associated with nonsignificantly decreased risks; only for linolenic acid did these associations persist in subgroup analyses. No associations were found for intake of arachidonic acid, eicosapentaenoic acid, or docosahexaenoic acid.

CONCLUSIONS

These data suggest that certain fatty acids might be involved in prostate carcinoma occurrence, although the possibility that these were chance findings cannot be ruled out.

Authors+Show Affiliations

Department of Epidemiology, Maastricht University, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10491529

Citation

Schuurman, A G., et al. "Association of Energy and Fat Intake With Prostate Carcinoma Risk: Results From the Netherlands Cohort Study." Cancer, vol. 86, no. 6, 1999, pp. 1019-27.
Schuurman AG, van den Brandt PA, Dorant E, et al. Association of energy and fat intake with prostate carcinoma risk: results from The Netherlands Cohort Study. Cancer. 1999;86(6):1019-27.
Schuurman, A. G., van den Brandt, P. A., Dorant, E., Brants, H. A., & Goldbohm, R. A. (1999). Association of energy and fat intake with prostate carcinoma risk: results from The Netherlands Cohort Study. Cancer, 86(6), 1019-27.
Schuurman AG, et al. Association of Energy and Fat Intake With Prostate Carcinoma Risk: Results From the Netherlands Cohort Study. Cancer. 1999 Sep 15;86(6):1019-27. PubMed PMID: 10491529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of energy and fat intake with prostate carcinoma risk: results from The Netherlands Cohort Study. AU - Schuurman,A G, AU - van den Brandt,P A, AU - Dorant,E, AU - Brants,H A, AU - Goldbohm,R A, PY - 1999/9/24/pubmed PY - 1999/9/24/medline PY - 1999/9/24/entrez SP - 1019 EP - 27 JF - Cancer JO - Cancer VL - 86 IS - 6 N2 - BACKGROUND: The roles of energy and fat intake as risk factors for prostate carcinoma are still questionable. Therefore, these factors were evaluated in the Netherlands Cohort Study described in this article. METHODS: The cohort study consisted of 58,279 men ages 55-69 years at baseline in 1986. After 6.3 years of follow-up, 642 incident prostate carcinoma cases were available for analysis. Intake of energy, fat, and separate fatty acids were measured by means of a self-administered questionnaire; fat intake was adjusted for energy by regression analysis. The case-cohort method was used to calculate rate ratios (RRs). Analyses were conducted for all prostate carcinoma cases together as well as for case subgroups (latent vs. nonlatent and localized vs. advanced). RESULTS: No associations were found in multivariate analyses between prostate carcinoma and intake of energy, total fat, total saturated fatty acids, or total trans unsaturated fatty acids (RR highest vs. lowest quintile: 0.99, 1.10, 1.19, and 0.99, respectively). Oleic acid intake showed a nonsignificant positive association (RR = 1.38, 95% CI: 0.88-2.19). Positive associations were also observed for intake of oleic acid in subgroup analyses. Linoleic (RR = 0.78, 95% CI: 0. 56-1.09) and linolenic (RR = 0.76, 95% CI: 0.66-1.04) acid intake were associated with nonsignificantly decreased risks; only for linolenic acid did these associations persist in subgroup analyses. No associations were found for intake of arachidonic acid, eicosapentaenoic acid, or docosahexaenoic acid. CONCLUSIONS: These data suggest that certain fatty acids might be involved in prostate carcinoma occurrence, although the possibility that these were chance findings cannot be ruled out. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/10491529/Association_of_energy_and_fat_intake_with_prostate_carcinoma_risk:_results_from_The_Netherlands_Cohort_Study_ L2 - https://ClinicalTrials.gov/search/term=10491529 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -