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Compliance and tolerability of mefloquine and chloroquine plus proguanil for long-term malaria chemoprophylaxis in groups at particular risk (the military).
Trans R Soc Trop Med Hyg. 1999 Jan-Feb; 93(1):73-7.TR

Abstract

An historical prospective study was performed on 5120 Italian soldiers deployed in Somalia and Mozambique in 1992-94, to determine compliance and tolerability of long-term malaria chemoprophylaxis with chloroquine plus proguanil (C + P) and with mefloquine. Compliance with C + P among 3734 soldiers on duty in Somalia for 3.8 +/- 1.8 months and with mefloquine among 1386 soldiers on duty in Mozambique for 3.4 +/- 1.5 months was 90.3% and 95.7%, respectively (P < 0.01). Chemoprophylaxis curtailment rate due to side-effects was 1.5% among C + P users and 0.9% among mefloquine users (P = NS). Compliance with chemoprophylaxis and medication curtailment rate due to side-effects did not change significantly for either C + P or mefloquine, even after 3 months of continuous prophylaxis. Chemoprophylaxis curtailment rate was significantly lower in subjects aged < or = 25 years than in older subjects (1.3% vs. 2.5% for C + P [P < 0.05] and 0.4% vs. 3.3% for mefloquine [P < 0.01]). These results further support the evidence that both C + P and mefloquine regimens may be safely used in long-term malaria chemoprophylaxis. Moreover, weekly mefloquine seems easier to perform than C + P and not to increase prophylaxis discontinuation due to side-effects. Mefloquine regimen should therefore be considered the elective chemoprophylaxis for groups at particular risk of chloroquine-resistant Plasmodium falciparum malaria and especially for young male subjects.

Authors+Show Affiliations

Ospedale Militare, Chieti, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10492796

Citation

Peragallo, M S., et al. "Compliance and Tolerability of Mefloquine and Chloroquine Plus Proguanil for Long-term Malaria Chemoprophylaxis in Groups at Particular Risk (the Military)." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 93, no. 1, 1999, pp. 73-7.
Peragallo MS, Sabatinelli G, Sarnicola G. Compliance and tolerability of mefloquine and chloroquine plus proguanil for long-term malaria chemoprophylaxis in groups at particular risk (the military). Trans R Soc Trop Med Hyg. 1999;93(1):73-7.
Peragallo, M. S., Sabatinelli, G., & Sarnicola, G. (1999). Compliance and tolerability of mefloquine and chloroquine plus proguanil for long-term malaria chemoprophylaxis in groups at particular risk (the military). Transactions of the Royal Society of Tropical Medicine and Hygiene, 93(1), 73-7.
Peragallo MS, Sabatinelli G, Sarnicola G. Compliance and Tolerability of Mefloquine and Chloroquine Plus Proguanil for Long-term Malaria Chemoprophylaxis in Groups at Particular Risk (the Military). Trans R Soc Trop Med Hyg. 1999 Jan-Feb;93(1):73-7. PubMed PMID: 10492796.
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TY - JOUR T1 - Compliance and tolerability of mefloquine and chloroquine plus proguanil for long-term malaria chemoprophylaxis in groups at particular risk (the military). AU - Peragallo,M S, AU - Sabatinelli,G, AU - Sarnicola,G, PY - 1999/9/24/pubmed PY - 1999/9/24/medline PY - 1999/9/24/entrez SP - 73 EP - 7 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans R Soc Trop Med Hyg VL - 93 IS - 1 N2 - An historical prospective study was performed on 5120 Italian soldiers deployed in Somalia and Mozambique in 1992-94, to determine compliance and tolerability of long-term malaria chemoprophylaxis with chloroquine plus proguanil (C + P) and with mefloquine. Compliance with C + P among 3734 soldiers on duty in Somalia for 3.8 +/- 1.8 months and with mefloquine among 1386 soldiers on duty in Mozambique for 3.4 +/- 1.5 months was 90.3% and 95.7%, respectively (P < 0.01). Chemoprophylaxis curtailment rate due to side-effects was 1.5% among C + P users and 0.9% among mefloquine users (P = NS). Compliance with chemoprophylaxis and medication curtailment rate due to side-effects did not change significantly for either C + P or mefloquine, even after 3 months of continuous prophylaxis. Chemoprophylaxis curtailment rate was significantly lower in subjects aged < or = 25 years than in older subjects (1.3% vs. 2.5% for C + P [P < 0.05] and 0.4% vs. 3.3% for mefloquine [P < 0.01]). These results further support the evidence that both C + P and mefloquine regimens may be safely used in long-term malaria chemoprophylaxis. Moreover, weekly mefloquine seems easier to perform than C + P and not to increase prophylaxis discontinuation due to side-effects. Mefloquine regimen should therefore be considered the elective chemoprophylaxis for groups at particular risk of chloroquine-resistant Plasmodium falciparum malaria and especially for young male subjects. SN - 0035-9203 UR - https://www.unboundmedicine.com/medline/citation/10492796/Compliance_and_tolerability_of_mefloquine_and_chloroquine_plus_proguanil_for_long_term_malaria_chemoprophylaxis_in_groups_at_particular_risk__the_military__ L2 - https://academic.oup.com/trstmh/article-lookup/doi/10.1016/s0035-9203(99)90187-6 DB - PRIME DP - Unbound Medicine ER -