Tags

Type your tag names separated by a space and hit enter

Leptin concentrations in cord blood in normal newborn infants and offspring of diabetic mothers.
Horm Metab Res 1999; 31(8):467-71HM

Abstract

Leptin has been implicated in the regulation of body weight and energy balance; Leptin is produced by adipocytes and placental tissue. Chronic fetal hyperinsulinemia and accelerated fetal growth with increased amounts of body fat are frequent findings in the offspring of diabetic mothers. In this study, we examined whether leptin levels in cord blood of infants of type 1 diabetic mothers (n = 29), gestational diabetic mothers (n = 6 and controls (n = 96) correlated with level of maternal glucose control, maternal leptin level at delivery, gender, fetal and placental size, and C-peptide in cord blood at birth. Leptin was significantly elevated in infants of type 1 diabetic (24.7 ng/ml) and gestational diabetic mothers (29.3 ng/ml) as compared to controls (7.9 ng/ml). C-peptide was also significantly higher in infants of type 1 diabetic (0.91 nmol/l) and gestational diabetic mothers (0.99 nmol/l) vs controls (0.34 nmol/l). Infants of type 1 diabetic mothers with a leptin level in cord blood above the upper normal range, i.e. > 30 ng/ml (n = 13), had an average maternal HbA1c level of 5.4% (normal < 5.5%) that was not different from 5.2% in infants with a leptin level < 30 ng/ml (n = 15). In both neonatal groups of diabetic mothers, leptin in cord blood did not correlate with maternal leptin concentrations, placental weight, birthweight, gender and cord blood C-peptide. In controls, leptin in cord blood was higher in girls than in boys (p = 0.044) and correlated significantly with birthweight (p = 0.41, p < 0.001) and cord blood C-peptide (p = 0.44, p < 0.001) but not with maternal leptin level or placental weight. The 3-4 times higher leptin levels in the offspring of diabetic mothers than normal could reflect increased adipose tissue mass and/or increased contribution from other sources such as placental tissue.

Authors+Show Affiliations

Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden. bengt.persson@swipnet.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10494872

Citation

Persson, B, et al. "Leptin Concentrations in Cord Blood in Normal Newborn Infants and Offspring of Diabetic Mothers." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 31, no. 8, 1999, pp. 467-71.
Persson B, Westgren M, Celsi G, et al. Leptin concentrations in cord blood in normal newborn infants and offspring of diabetic mothers. Horm Metab Res. 1999;31(8):467-71.
Persson, B., Westgren, M., Celsi, G., Nord, E., & Ortqvist, E. (1999). Leptin concentrations in cord blood in normal newborn infants and offspring of diabetic mothers. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 31(8), pp. 467-71.
Persson B, et al. Leptin Concentrations in Cord Blood in Normal Newborn Infants and Offspring of Diabetic Mothers. Horm Metab Res. 1999;31(8):467-71. PubMed PMID: 10494872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leptin concentrations in cord blood in normal newborn infants and offspring of diabetic mothers. AU - Persson,B, AU - Westgren,M, AU - Celsi,G, AU - Nord,E, AU - Ortqvist,E, PY - 1999/9/24/pubmed PY - 1999/9/24/medline PY - 1999/9/24/entrez SP - 467 EP - 71 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 31 IS - 8 N2 - Leptin has been implicated in the regulation of body weight and energy balance; Leptin is produced by adipocytes and placental tissue. Chronic fetal hyperinsulinemia and accelerated fetal growth with increased amounts of body fat are frequent findings in the offspring of diabetic mothers. In this study, we examined whether leptin levels in cord blood of infants of type 1 diabetic mothers (n = 29), gestational diabetic mothers (n = 6 and controls (n = 96) correlated with level of maternal glucose control, maternal leptin level at delivery, gender, fetal and placental size, and C-peptide in cord blood at birth. Leptin was significantly elevated in infants of type 1 diabetic (24.7 ng/ml) and gestational diabetic mothers (29.3 ng/ml) as compared to controls (7.9 ng/ml). C-peptide was also significantly higher in infants of type 1 diabetic (0.91 nmol/l) and gestational diabetic mothers (0.99 nmol/l) vs controls (0.34 nmol/l). Infants of type 1 diabetic mothers with a leptin level in cord blood above the upper normal range, i.e. > 30 ng/ml (n = 13), had an average maternal HbA1c level of 5.4% (normal < 5.5%) that was not different from 5.2% in infants with a leptin level < 30 ng/ml (n = 15). In both neonatal groups of diabetic mothers, leptin in cord blood did not correlate with maternal leptin concentrations, placental weight, birthweight, gender and cord blood C-peptide. In controls, leptin in cord blood was higher in girls than in boys (p = 0.044) and correlated significantly with birthweight (p = 0.41, p < 0.001) and cord blood C-peptide (p = 0.44, p < 0.001) but not with maternal leptin level or placental weight. The 3-4 times higher leptin levels in the offspring of diabetic mothers than normal could reflect increased adipose tissue mass and/or increased contribution from other sources such as placental tissue. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/10494872/Leptin_concentrations_in_cord_blood_in_normal_newborn_infants_and_offspring_of_diabetic_mothers_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-978776 DB - PRIME DP - Unbound Medicine ER -