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Bone recovery after a gluten-free diet: a 5-year follow-up study.
Bone 1999; 25(3):355-60BONE

Abstract

The purpose of our study was to investigate the recovery of bone disease in celiac patients during 5 years of a gluten-free diet. The study group consisted of 28 newly diagnosed celiac patients (9 men, 19 women) recruited between 1990 and 1991. Six patients withdrew from the 5-year follow-up. Compliance with the gluten-free diet was good: 96% at 1 year and 82% at 5 years. During the follow-up period, the body mass index increased significantly (8%). Both in men and women, bone mineral density (BMD) values determined by dual X-ray absorptiometry (DXA) increased at the lumbar spine (2%), the femoral neck (1%), the trochanter (6%), and the Wards' area (3%) during the follow-up. The increase in BMD was found already during the first year of follow-up. After 1 year, BMD increased or remained the same in 69% of the patients at the lumbar spine and in 67% of the patients at the femoral neck, 89% of patients at the throchanter, and 67% of patients at the Wards' area. During the 5-year follow-up, these figures were 52%, 46%, 68%, and 59%, respectively. At the baseline, 19 out of 28 patients, after 1 year, 14 out of 26 patients, and after 5 years, 2 out of 26 patients had low serum 25(OH)D vitamin values (p = 0.0001). A high serum parathormone value was noticed in 6 out of 25 patients at the baseline, but after 1 year, 5 of them showed normalized values (p = 0.03). According to our results, bone disease in celiac patients is cured in most patients during 5 years on a gluten-free diet. The improvement in BMD mostly occurred already within the first year after the establishment of a gluten-free diet.

Authors+Show Affiliations

Department of Clinical Nutrition, University of Kuopio, Finland. Tarja.Kemppainen@uku.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

10495140

Citation

Kemppainen, T, et al. "Bone Recovery After a Gluten-free Diet: a 5-year Follow-up Study." Bone, vol. 25, no. 3, 1999, pp. 355-60.
Kemppainen T, Kröger H, Janatuinen E, et al. Bone recovery after a gluten-free diet: a 5-year follow-up study. Bone. 1999;25(3):355-60.
Kemppainen, T., Kröger, H., Janatuinen, E., Arnala, I., Lamberg-Allardt, C., Kärkkäinen, M., ... Uusitupa, M. (1999). Bone recovery after a gluten-free diet: a 5-year follow-up study. Bone, 25(3), pp. 355-60.
Kemppainen T, et al. Bone Recovery After a Gluten-free Diet: a 5-year Follow-up Study. Bone. 1999;25(3):355-60. PubMed PMID: 10495140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone recovery after a gluten-free diet: a 5-year follow-up study. AU - Kemppainen,T, AU - Kröger,H, AU - Janatuinen,E, AU - Arnala,I, AU - Lamberg-Allardt,C, AU - Kärkkäinen,M, AU - Kosma,V M, AU - Julkunen,R, AU - Jurvelin,J, AU - Alhava,E, AU - Uusitupa,M, PY - 1999/9/24/pubmed PY - 1999/9/24/medline PY - 1999/9/24/entrez SP - 355 EP - 60 JF - Bone JO - Bone VL - 25 IS - 3 N2 - The purpose of our study was to investigate the recovery of bone disease in celiac patients during 5 years of a gluten-free diet. The study group consisted of 28 newly diagnosed celiac patients (9 men, 19 women) recruited between 1990 and 1991. Six patients withdrew from the 5-year follow-up. Compliance with the gluten-free diet was good: 96% at 1 year and 82% at 5 years. During the follow-up period, the body mass index increased significantly (8%). Both in men and women, bone mineral density (BMD) values determined by dual X-ray absorptiometry (DXA) increased at the lumbar spine (2%), the femoral neck (1%), the trochanter (6%), and the Wards' area (3%) during the follow-up. The increase in BMD was found already during the first year of follow-up. After 1 year, BMD increased or remained the same in 69% of the patients at the lumbar spine and in 67% of the patients at the femoral neck, 89% of patients at the throchanter, and 67% of patients at the Wards' area. During the 5-year follow-up, these figures were 52%, 46%, 68%, and 59%, respectively. At the baseline, 19 out of 28 patients, after 1 year, 14 out of 26 patients, and after 5 years, 2 out of 26 patients had low serum 25(OH)D vitamin values (p = 0.0001). A high serum parathormone value was noticed in 6 out of 25 patients at the baseline, but after 1 year, 5 of them showed normalized values (p = 0.03). According to our results, bone disease in celiac patients is cured in most patients during 5 years on a gluten-free diet. The improvement in BMD mostly occurred already within the first year after the establishment of a gluten-free diet. SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/10495140/Bone_recovery_after_a_gluten_free_diet:_a_5_year_follow_up_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756-3282(99)00171-4 DB - PRIME DP - Unbound Medicine ER -