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Antioxidant vitamins and the prevention of coronary heart disease.
Am Fam Physician. 1999 Sep 01; 60(3):895-904.AF

Abstract

Clinical use of antioxidant vitamin supplementation may help to prevent coronary heart disease (CHD). Epidemiologic studies find lower CHD morbidity and mortality in persons who consume larger quantities of antioxidants in foods or supplements. Clinical trials indicate that supplementation with certain nutrients is beneficial in reducing the incidence of CHD events. Recent studies show that supplementation with antioxidant vitamins E and C have benefits in CHD prevention; however, supplementation with beta-carotene may have deleterious effects and is not recommended. Current evidence suggests that patients with CHD would probably benefit from taking vitamin E in a dosage of 400 IU per day and vitamin C in a dosage of 500 to 1,000 mg per day. Clinicians may also want to consider vitamin supplementation for CHD prevention in high-risk patients. Folate lowers elevated homocysteine levels, but evidence for routine supplemental use does not yet exist. Other nutritional supplements are currently under investigation.

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Authors+Show Affiliations

Adams AK
University of Wisconsin Medical School, Madison 53792-3248, USA.
Wermuth EO
No affiliation info available
McBride PE
No affiliation info available

MeSH

AntioxidantsAscorbic AcidCoronary DiseaseHumansPatient Education as TopicRandomized Controlled Trials as TopicTeaching MaterialsVitamin EVitaminsbeta Carotene

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10498115

Citation

Adams, A K., et al. "Antioxidant Vitamins and the Prevention of Coronary Heart Disease." American Family Physician, vol. 60, no. 3, 1999, pp. 895-904.
Adams AK, Wermuth EO, McBride PE. Antioxidant vitamins and the prevention of coronary heart disease. Am Fam Physician. 1999;60(3):895-904.
Adams, A. K., Wermuth, E. O., & McBride, P. E. (1999). Antioxidant vitamins and the prevention of coronary heart disease. American Family Physician, 60(3), 895-904.
Adams AK, Wermuth EO, McBride PE. Antioxidant Vitamins and the Prevention of Coronary Heart Disease. Am Fam Physician. 1999 Sep 1;60(3):895-904. PubMed PMID: 10498115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant vitamins and the prevention of coronary heart disease. AU - Adams,A K, AU - Wermuth,E O, AU - McBride,P E, PY - 1999/9/25/pubmed PY - 1999/9/25/medline PY - 1999/9/25/entrez SP - 895 EP - 904 JF - American family physician JO - Am Fam Physician VL - 60 IS - 3 N2 - Clinical use of antioxidant vitamin supplementation may help to prevent coronary heart disease (CHD). Epidemiologic studies find lower CHD morbidity and mortality in persons who consume larger quantities of antioxidants in foods or supplements. Clinical trials indicate that supplementation with certain nutrients is beneficial in reducing the incidence of CHD events. Recent studies show that supplementation with antioxidant vitamins E and C have benefits in CHD prevention; however, supplementation with beta-carotene may have deleterious effects and is not recommended. Current evidence suggests that patients with CHD would probably benefit from taking vitamin E in a dosage of 400 IU per day and vitamin C in a dosage of 500 to 1,000 mg per day. Clinicians may also want to consider vitamin supplementation for CHD prevention in high-risk patients. Folate lowers elevated homocysteine levels, but evidence for routine supplemental use does not yet exist. Other nutritional supplements are currently under investigation. SN - 0002-838X UR - https://www.unboundmedicine.com/medline/citation/10498115/Antioxidant_vitamins_and_the_prevention_of_coronary_heart_disease_ L2 - https://www.aafp.org/link_out?pmid=10498115 DB - PRIME DP - Unbound Medicine ER -