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Central motor conduction in hereditary motor and sensory neuropathy and hereditary spastic paraplegia.
Electromyogr Clin Neurophysiol. 1999 Sep; 39(6):331-5.EC

Abstract

Conduction of the central motor pathways (CMCT) by magnetic stimulation of the motor cortex (TMS) was performed in 17 patients with hereditary motor sensory neuropathy (HMSN) and 2 siblings with hereditary spastic paraplegia (HSP). CMCT was prolonged in two patients with HMSN I with associated pyramidal features and in two subjects with HMSN II without clinical pyramidal signs. CMCT may be abnormal in HMSN due to central motor pathways involvement or altered spinal excitability with increased synaptic delay. CMCT was normal in the upper limbs in patients with HSP but increased in the legs. Diagnostic yield of TMS increased in less disabled cases with HSP when selective conduction at the spinal level (C7-S1) was calculated. Abnormal spinal conduction in HSP is consistent with degeneration of the crossed corticospinal tracts at the thoracic level found in neuropathologic observations.

Authors+Show Affiliations

Unidad de Electromiografía, Clínica La Luz, Madrid, Spain.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10499202

Citation

Cruz Martínez, A, and J Tejada. "Central Motor Conduction in Hereditary Motor and Sensory Neuropathy and Hereditary Spastic Paraplegia." Electromyography and Clinical Neurophysiology, vol. 39, no. 6, 1999, pp. 331-5.
Cruz Martínez A, Tejada J. Central motor conduction in hereditary motor and sensory neuropathy and hereditary spastic paraplegia. Electromyogr Clin Neurophysiol. 1999;39(6):331-5.
Cruz Martínez, A., & Tejada, J. (1999). Central motor conduction in hereditary motor and sensory neuropathy and hereditary spastic paraplegia. Electromyography and Clinical Neurophysiology, 39(6), 331-5.
Cruz Martínez A, Tejada J. Central Motor Conduction in Hereditary Motor and Sensory Neuropathy and Hereditary Spastic Paraplegia. Electromyogr Clin Neurophysiol. 1999;39(6):331-5. PubMed PMID: 10499202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Central motor conduction in hereditary motor and sensory neuropathy and hereditary spastic paraplegia. AU - Cruz Martínez,A, AU - Tejada,J, PY - 1999/9/28/pubmed PY - 1999/9/28/medline PY - 1999/9/28/entrez SP - 331 EP - 5 JF - Electromyography and clinical neurophysiology JO - Electromyogr Clin Neurophysiol VL - 39 IS - 6 N2 - Conduction of the central motor pathways (CMCT) by magnetic stimulation of the motor cortex (TMS) was performed in 17 patients with hereditary motor sensory neuropathy (HMSN) and 2 siblings with hereditary spastic paraplegia (HSP). CMCT was prolonged in two patients with HMSN I with associated pyramidal features and in two subjects with HMSN II without clinical pyramidal signs. CMCT may be abnormal in HMSN due to central motor pathways involvement or altered spinal excitability with increased synaptic delay. CMCT was normal in the upper limbs in patients with HSP but increased in the legs. Diagnostic yield of TMS increased in less disabled cases with HSP when selective conduction at the spinal level (C7-S1) was calculated. Abnormal spinal conduction in HSP is consistent with degeneration of the crossed corticospinal tracts at the thoracic level found in neuropathologic observations. SN - 0301-150X UR - https://www.unboundmedicine.com/medline/citation/10499202/Central_motor_conduction_in_hereditary_motor_and_sensory_neuropathy_and_hereditary_spastic_paraplegia_ L2 - http://www.diseaseinfosearch.org/result/4890 DB - PRIME DP - Unbound Medicine ER -