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Nutrition and inflammatory bowel disease: an update.
Scand J Gastroenterol Suppl 1999; 230:95-105SJ

Abstract

BACKGROUND

Inflammatory bowel disease (IBD) is a chronic inflammatory process, the aetiology of which remains unknown. Nutrition may play an important role in the pathogenesis and treatment of IBD. The evidence regarding the role of specific dietary components in the pathogenesis of IBD is still inconclusive. Many studies have been subject to methodological limitations; studies of better design are necessary to confirm the hypothesis that nutritional factors may indeed play a role in the development of IBD. Several studies have reported nutritional and functional deficiencies in IBD patients, especially in Crohn's disease. It is, however, hard to discriminate between disease-induced and malnutrition-induced changes in nutritional parameters. Maintaining adequate nutritional status has been suggested to be beneficial to the course of the disease in IBD. Studies have provided further insight into the possible beneficial effects of nutritional supplementation as primary and adjunctive therapy in IBD. The effects of specific nutritional therapy may be caused by alterations in intestinal flora and hence in the production of intraluminal proinflammatory substances. Immunonutrients such as n-3 fatty acids and antioxidants may also play a role in the treatment of IBD. In this paper, the relation between nutritional aetiological factors, nutritional status and nutritional therapy is discussed in detail.

Authors+Show Affiliations

Dept. of Gastroenterology and Hepatology, University Hospital Maastricht, The Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10499469

Citation

Geerling, B J., et al. "Nutrition and Inflammatory Bowel Disease: an Update." Scandinavian Journal of Gastroenterology. Supplement, vol. 230, 1999, pp. 95-105.
Geerling BJ, Stockbrügger RW, Brummer RJ. Nutrition and inflammatory bowel disease: an update. Scand J Gastroenterol Suppl. 1999;230:95-105.
Geerling, B. J., Stockbrügger, R. W., & Brummer, R. J. (1999). Nutrition and inflammatory bowel disease: an update. Scandinavian Journal of Gastroenterology. Supplement, 230, pp. 95-105.
Geerling BJ, Stockbrügger RW, Brummer RJ. Nutrition and Inflammatory Bowel Disease: an Update. Scand J Gastroenterol Suppl. 1999;230:95-105. PubMed PMID: 10499469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutrition and inflammatory bowel disease: an update. AU - Geerling,B J, AU - Stockbrügger,R W, AU - Brummer,R J, PY - 1999/9/28/pubmed PY - 1999/9/28/medline PY - 1999/9/28/entrez SP - 95 EP - 105 JF - Scandinavian journal of gastroenterology. Supplement JO - Scand. J. Gastroenterol. Suppl. VL - 230 N2 - BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammatory process, the aetiology of which remains unknown. Nutrition may play an important role in the pathogenesis and treatment of IBD. The evidence regarding the role of specific dietary components in the pathogenesis of IBD is still inconclusive. Many studies have been subject to methodological limitations; studies of better design are necessary to confirm the hypothesis that nutritional factors may indeed play a role in the development of IBD. Several studies have reported nutritional and functional deficiencies in IBD patients, especially in Crohn's disease. It is, however, hard to discriminate between disease-induced and malnutrition-induced changes in nutritional parameters. Maintaining adequate nutritional status has been suggested to be beneficial to the course of the disease in IBD. Studies have provided further insight into the possible beneficial effects of nutritional supplementation as primary and adjunctive therapy in IBD. The effects of specific nutritional therapy may be caused by alterations in intestinal flora and hence in the production of intraluminal proinflammatory substances. Immunonutrients such as n-3 fatty acids and antioxidants may also play a role in the treatment of IBD. In this paper, the relation between nutritional aetiological factors, nutritional status and nutritional therapy is discussed in detail. SN - 0085-5928 UR - https://www.unboundmedicine.com/medline/citation/10499469/Nutrition_and_inflammatory_bowel_disease:_an_update_ L2 - https://medlineplus.gov/nutrition.html DB - PRIME DP - Unbound Medicine ER -