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A prospective study of carotenoid intake and risk of cataract extraction in US men.
Am J Clin Nutr. 1999 Oct; 70(4):517-24.AJ

Abstract

BACKGROUND

Dietary antioxidants, including carotenoids, are hypothesized to decrease the risk of age-related cataracts by preventing oxidation of proteins or lipids within the lens. However, prospective epidemiologic data concerning this phenomenon are limited.

OBJECTIVE

Our objective was to examine prospectively the association between carotenoid and vitamin A intakes and cataract extraction in men.

DESIGN

US male health professionals (n = 36644) who were 45-75 y of age in 1986 were included in this prospective cohort study. Others were subsequently included as they became 45 y of age. A detailed dietary questionnaire was used to assess intake of carotenoids and other nutrients. During 8 y of follow-up, 840 cases of senile cataract extraction were documented.

RESULTS

We observed a modestly lower risk of cataract extraction in men with higher intakes of lutein and zeaxanthin but not of other carotenoids (alpha-carotene, beta-carotene, lycopene, and beta-cryptoxanthin) or vitamin A after other potential risk factors, including age and smoking, were controlled for. Men in the highest fifth of lutein and zeaxanthin intake had a 19% lower risk of cataract relative to men in the lowest fifth (relative risk: 0.81; 95% CI: 0.65, 1.01; P for trend = 0.03). Among specific foods high in carotenoids, broccoli and spinach were most consistently associated with a lower risk of cataract.

CONCLUSIONS

Lutein and zeaxanthin may decrease the risk of cataracts severe enough to require extraction, although this relation appears modest in magnitude. The present findings add support for recommendations to consume vegetables and fruit high in carotenoids daily.

Authors+Show Affiliations

Departments of Epidemiology, Nutrition, and Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA. lisa.brown@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10500021

Citation

Brown, L, et al. "A Prospective Study of Carotenoid Intake and Risk of Cataract Extraction in US Men." The American Journal of Clinical Nutrition, vol. 70, no. 4, 1999, pp. 517-24.
Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr. 1999;70(4):517-24.
Brown, L., Rimm, E. B., Seddon, J. M., Giovannucci, E. L., Chasan-Taber, L., Spiegelman, D., Willett, W. C., & Hankinson, S. E. (1999). A prospective study of carotenoid intake and risk of cataract extraction in US men. The American Journal of Clinical Nutrition, 70(4), 517-24.
Brown L, et al. A Prospective Study of Carotenoid Intake and Risk of Cataract Extraction in US Men. Am J Clin Nutr. 1999;70(4):517-24. PubMed PMID: 10500021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of carotenoid intake and risk of cataract extraction in US men. AU - Brown,L, AU - Rimm,E B, AU - Seddon,J M, AU - Giovannucci,E L, AU - Chasan-Taber,L, AU - Spiegelman,D, AU - Willett,W C, AU - Hankinson,S E, PY - 1999/9/29/pubmed PY - 1999/9/29/medline PY - 1999/9/29/entrez SP - 517 EP - 24 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 70 IS - 4 N2 - BACKGROUND: Dietary antioxidants, including carotenoids, are hypothesized to decrease the risk of age-related cataracts by preventing oxidation of proteins or lipids within the lens. However, prospective epidemiologic data concerning this phenomenon are limited. OBJECTIVE: Our objective was to examine prospectively the association between carotenoid and vitamin A intakes and cataract extraction in men. DESIGN: US male health professionals (n = 36644) who were 45-75 y of age in 1986 were included in this prospective cohort study. Others were subsequently included as they became 45 y of age. A detailed dietary questionnaire was used to assess intake of carotenoids and other nutrients. During 8 y of follow-up, 840 cases of senile cataract extraction were documented. RESULTS: We observed a modestly lower risk of cataract extraction in men with higher intakes of lutein and zeaxanthin but not of other carotenoids (alpha-carotene, beta-carotene, lycopene, and beta-cryptoxanthin) or vitamin A after other potential risk factors, including age and smoking, were controlled for. Men in the highest fifth of lutein and zeaxanthin intake had a 19% lower risk of cataract relative to men in the lowest fifth (relative risk: 0.81; 95% CI: 0.65, 1.01; P for trend = 0.03). Among specific foods high in carotenoids, broccoli and spinach were most consistently associated with a lower risk of cataract. CONCLUSIONS: Lutein and zeaxanthin may decrease the risk of cataracts severe enough to require extraction, although this relation appears modest in magnitude. The present findings add support for recommendations to consume vegetables and fruit high in carotenoids daily. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/10500021/A_prospective_study_of_carotenoid_intake_and_risk_of_cataract_extraction_in_US_men_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/70.4.517 DB - PRIME DP - Unbound Medicine ER -