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Plasma fatty acids concentrations in postoperative patients with biliary atresia.

Abstract

The concentrations of plasma fatty acids in postoperative patients with biliary atresia (BA) were measured to clarify whether they had essential fatty acid deficiency. Thirty-eight fasting blood samples from 14 postoperative patients with BA were studied. All of them had the hepatic portoenterostomy without any stoma. Samples were divided into three groups on the basis of liver function. The concentrations of fatty acids in the plasma fat were measured quantitatively. Non-essential fatty acids levels were increased and omega-3 fatty acids levels were decreased with the progress of deterioration of hepatic function. Regarding omega-6 fatty acids, C18:2 and 20:4 did not show any significant difference between the three groups and the control, and only C20:3 increased with the deterioration of liver dysfunction. The ratio of C20:3 (omega-6) to C20:4 (omega-6) was increased significantly with the progress of liver dysfunction. The activity of delta-5 desaturase was suspected to be suppressed in BA patients with poor liver function. The BA patients with poor bile flow did not show any decrease of omega-6 fatty acids in the plasma, but were at risk of developing omega-3 fatty acid deficiency.

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  • Authors+Show Affiliations

    ,

    Department of Pediatric Surgery, Kagoshima University Faculty of Medicine, Japan. takamatu@khosp2.kufm.kagoshima-u.ac.jp

    , , , , ,

    Source

    MeSH

    Biliary Atresia
    Child
    Child, Preschool
    Fatty Acids
    Fatty Acids, Essential
    Fatty Acids, Omega-3
    Fatty Acids, Omega-6
    Fatty Acids, Unsaturated
    Humans
    Infant
    Liver
    Portoenterostomy, Hepatic
    Postoperative Period

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    10501288

    Citation

    Takamatsu, H, et al. "Plasma Fatty Acids Concentrations in Postoperative Patients With Biliary Atresia." Nutrition (Burbank, Los Angeles County, Calif.), vol. 15, no. 10, 1999, pp. 755-9.
    Takamatsu H, Noguchi H, Tahara H, et al. Plasma fatty acids concentrations in postoperative patients with biliary atresia. Nutrition. 1999;15(10):755-9.
    Takamatsu, H., Noguchi, H., Tahara, H., Kaji, T., Shimono, R., Ikee, T., & Andoh, T. (1999). Plasma fatty acids concentrations in postoperative patients with biliary atresia. Nutrition (Burbank, Los Angeles County, Calif.), 15(10), pp. 755-9.
    Takamatsu H, et al. Plasma Fatty Acids Concentrations in Postoperative Patients With Biliary Atresia. Nutrition. 1999;15(10):755-9. PubMed PMID: 10501288.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Plasma fatty acids concentrations in postoperative patients with biliary atresia. AU - Takamatsu,H, AU - Noguchi,H, AU - Tahara,H, AU - Kaji,T, AU - Shimono,R, AU - Ikee,T, AU - Andoh,T, PY - 1999/9/29/pubmed PY - 1999/9/29/medline PY - 1999/9/29/entrez SP - 755 EP - 9 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 15 IS - 10 N2 - The concentrations of plasma fatty acids in postoperative patients with biliary atresia (BA) were measured to clarify whether they had essential fatty acid deficiency. Thirty-eight fasting blood samples from 14 postoperative patients with BA were studied. All of them had the hepatic portoenterostomy without any stoma. Samples were divided into three groups on the basis of liver function. The concentrations of fatty acids in the plasma fat were measured quantitatively. Non-essential fatty acids levels were increased and omega-3 fatty acids levels were decreased with the progress of deterioration of hepatic function. Regarding omega-6 fatty acids, C18:2 and 20:4 did not show any significant difference between the three groups and the control, and only C20:3 increased with the deterioration of liver dysfunction. The ratio of C20:3 (omega-6) to C20:4 (omega-6) was increased significantly with the progress of liver dysfunction. The activity of delta-5 desaturase was suspected to be suppressed in BA patients with poor liver function. The BA patients with poor bile flow did not show any decrease of omega-6 fatty acids in the plasma, but were at risk of developing omega-3 fatty acid deficiency. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/10501288/Plasma_fatty_acids_concentrations_in_postoperative_patients_with_biliary_atresia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899900799001501 DB - PRIME DP - Unbound Medicine ER -