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Elevated endogenous cannabinoids in schizophrenia.
Neuroreport 1999; 10(8):1665-9N

Abstract

Evidence suggests that cannabinoid receptors, the pharmacologcial target of cannabis-derived drugs, and their accompanying system of endogenous activators may be dysfunctional in schizophrenia. To test this hypothesis, we examined whether endogenous cannabinoid concentrations in cerebrospinal fluid of schizophrenic patients are altered compared to nonschizophrenic controls. Endogenous cannabinoids were purified from cerebrospinal fluid of 10 patients with schizophrenia and 11 non-schizophrenic controls by high-performance liquid chromatography, and quantified by isotope dilution gas-chromatography/mass-spectrometry. Cerebrospinal concentrations of two endogenous cannabinoids (anandamide and palmitylethanolamide) were significantly higher in schizophrenic patients than non-schizophrenic controls (p < 0.05). By contrast, levels of 2-arachidonylglycerol, another endogenous cannabinoid lipid, were below detection in both groups. The findings did not seem attributable to gender, age or medication. Elevated anandamide and palmitylethanolamide levels in cerebrospinal fluid of schizophrenic patients may reflect an imbalance in endogenous cannabinoid signaling, which may contribute to the pathogenesis of schizophrenia.

Authors+Show Affiliations

Department of Clinical Psychiatry and Psychotherapy, Medizinische Hochschule Hannover, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10501554

Citation

Leweke, F M., et al. "Elevated Endogenous Cannabinoids in Schizophrenia." Neuroreport, vol. 10, no. 8, 1999, pp. 1665-9.
Leweke FM, Giuffrida A, Wurster U, et al. Elevated endogenous cannabinoids in schizophrenia. Neuroreport. 1999;10(8):1665-9.
Leweke, F. M., Giuffrida, A., Wurster, U., Emrich, H. M., & Piomelli, D. (1999). Elevated endogenous cannabinoids in schizophrenia. Neuroreport, 10(8), pp. 1665-9.
Leweke FM, et al. Elevated Endogenous Cannabinoids in Schizophrenia. Neuroreport. 1999 Jun 3;10(8):1665-9. PubMed PMID: 10501554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated endogenous cannabinoids in schizophrenia. AU - Leweke,F M, AU - Giuffrida,A, AU - Wurster,U, AU - Emrich,H M, AU - Piomelli,D, PY - 1999/9/29/pubmed PY - 1999/9/29/medline PY - 1999/9/29/entrez SP - 1665 EP - 9 JF - Neuroreport JO - Neuroreport VL - 10 IS - 8 N2 - Evidence suggests that cannabinoid receptors, the pharmacologcial target of cannabis-derived drugs, and their accompanying system of endogenous activators may be dysfunctional in schizophrenia. To test this hypothesis, we examined whether endogenous cannabinoid concentrations in cerebrospinal fluid of schizophrenic patients are altered compared to nonschizophrenic controls. Endogenous cannabinoids were purified from cerebrospinal fluid of 10 patients with schizophrenia and 11 non-schizophrenic controls by high-performance liquid chromatography, and quantified by isotope dilution gas-chromatography/mass-spectrometry. Cerebrospinal concentrations of two endogenous cannabinoids (anandamide and palmitylethanolamide) were significantly higher in schizophrenic patients than non-schizophrenic controls (p < 0.05). By contrast, levels of 2-arachidonylglycerol, another endogenous cannabinoid lipid, were below detection in both groups. The findings did not seem attributable to gender, age or medication. Elevated anandamide and palmitylethanolamide levels in cerebrospinal fluid of schizophrenic patients may reflect an imbalance in endogenous cannabinoid signaling, which may contribute to the pathogenesis of schizophrenia. SN - 0959-4965 UR - https://www.unboundmedicine.com/medline/citation/10501554/Elevated_endogenous_cannabinoids_in_schizophrenia_ L2 - http://Insights.ovid.com/pubmed?pmid=10501554 DB - PRIME DP - Unbound Medicine ER -