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Prevalence of antibodies to the hepatitis E virus in pigs from countries where hepatitis E is common or is rare in the human population.
J Med Virol. 1999 Nov; 59(3):297-302.JM

Abstract

Hepatitis E virus (HEV) is a very important public health concern in many developing countries where epidemics of hepatitis E are common. Sporadic cases of clinical hepatitis E not only occur in these countries but also occur uncommonly in patients with no known epidemiological exposure to HEV in industrialized countries. The source of infection in industrialized countries is unknown but it has been suggested that animals might serve as a reservoir for HEV in both settings. We recently identified and characterized an HEV strain (swine HEV) that infects large numbers of pigs in the United States. To assess the potential of pigs to serve as a global reservoir of HEV, we measured the prevalence of HEV antibodies in pigs in two countries where hepatitis E is endemic and two countries where it is not. Swine herds in all four countries contained many pigs that were seropositive for IgG anti-HEV, although the percentage of seropositive pigs varied greatly from herd to herd. A very limited number of pig handlers in the two endemic countries were also tested and most of them were found to be seropositive for HEV. The results from this study suggest that hepatitis E is enzootic in pigs regardless of whether HEV is endemic in the respective human population. J. Med. Virol. 59:297-302, 1999. Published 1999 Wiley-Liss, Inc.

Authors+Show Affiliations

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. xjmeng@vt.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10502259

Citation

Meng, X J., et al. "Prevalence of Antibodies to the Hepatitis E Virus in Pigs From Countries Where Hepatitis E Is Common or Is Rare in the Human Population." Journal of Medical Virology, vol. 59, no. 3, 1999, pp. 297-302.
Meng XJ, Dea S, Engle RE, et al. Prevalence of antibodies to the hepatitis E virus in pigs from countries where hepatitis E is common or is rare in the human population. J Med Virol. 1999;59(3):297-302.
Meng, X. J., Dea, S., Engle, R. E., Friendship, R., Lyoo, Y. S., Sirinarumitr, T., Urairong, K., Wang, D., Wong, D., Yoo, D., Zhang, Y., Purcell, R. H., & Emerson, S. U. (1999). Prevalence of antibodies to the hepatitis E virus in pigs from countries where hepatitis E is common or is rare in the human population. Journal of Medical Virology, 59(3), 297-302.
Meng XJ, et al. Prevalence of Antibodies to the Hepatitis E Virus in Pigs From Countries Where Hepatitis E Is Common or Is Rare in the Human Population. J Med Virol. 1999;59(3):297-302. PubMed PMID: 10502259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of antibodies to the hepatitis E virus in pigs from countries where hepatitis E is common or is rare in the human population. AU - Meng,X J, AU - Dea,S, AU - Engle,R E, AU - Friendship,R, AU - Lyoo,Y S, AU - Sirinarumitr,T, AU - Urairong,K, AU - Wang,D, AU - Wong,D, AU - Yoo,D, AU - Zhang,Y, AU - Purcell,R H, AU - Emerson,S U, PY - 1999/9/29/pubmed PY - 1999/9/29/medline PY - 1999/9/29/entrez SP - 297 EP - 302 JF - Journal of medical virology JO - J Med Virol VL - 59 IS - 3 N2 - Hepatitis E virus (HEV) is a very important public health concern in many developing countries where epidemics of hepatitis E are common. Sporadic cases of clinical hepatitis E not only occur in these countries but also occur uncommonly in patients with no known epidemiological exposure to HEV in industrialized countries. The source of infection in industrialized countries is unknown but it has been suggested that animals might serve as a reservoir for HEV in both settings. We recently identified and characterized an HEV strain (swine HEV) that infects large numbers of pigs in the United States. To assess the potential of pigs to serve as a global reservoir of HEV, we measured the prevalence of HEV antibodies in pigs in two countries where hepatitis E is endemic and two countries where it is not. Swine herds in all four countries contained many pigs that were seropositive for IgG anti-HEV, although the percentage of seropositive pigs varied greatly from herd to herd. A very limited number of pig handlers in the two endemic countries were also tested and most of them were found to be seropositive for HEV. The results from this study suggest that hepatitis E is enzootic in pigs regardless of whether HEV is endemic in the respective human population. J. Med. Virol. 59:297-302, 1999. Published 1999 Wiley-Liss, Inc. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/10502259/Prevalence_of_antibodies_to_the_hepatitis_E_virus_in_pigs_from_countries_where_hepatitis_E_is_common_or_is_rare_in_the_human_population_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0146-6615&date=1999&volume=59&issue=3&spage=297 DB - PRIME DP - Unbound Medicine ER -