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Chitosan microspheres prepared by spray drying.
Int J Pharm 1999; 187(1):53-65IJ

Abstract

Non-crosslinked and crosslinked chitosan microspheres were prepared by a spray drying method. The microspheres so prepared had a good sphericity and a smooth but distorted surface morphology. They were positively charged. The particle size ranged from 2 to 10 micron. The size and seta potential of the particles were influenced by the crosslinking level. With decreasing amount of crosslinking agent (either glutaraldehyde or formaldehyde), both particle size and zeta potential were increased. Preparation conditions also had some influence on the particle size. DSC studies revealed that the H2 antagonist drug cimetidine, as well as famotidine was molecularly dispersed inside the microspheres, in the form of a solid solution. The release of model drugs (cimetidine, famotidine and nizatidine) from these microspheres was fast, and accompanied by a burst effect.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10502613

Citation

He, P, et al. "Chitosan Microspheres Prepared By Spray Drying." International Journal of Pharmaceutics, vol. 187, no. 1, 1999, pp. 53-65.
He P, Davis SS, Illum L. Chitosan microspheres prepared by spray drying. Int J Pharm. 1999;187(1):53-65.
He, P., Davis, S. S., & Illum, L. (1999). Chitosan microspheres prepared by spray drying. International Journal of Pharmaceutics, 187(1), pp. 53-65.
He P, Davis SS, Illum L. Chitosan Microspheres Prepared By Spray Drying. Int J Pharm. 1999 Sep 30;187(1):53-65. PubMed PMID: 10502613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chitosan microspheres prepared by spray drying. AU - He,P, AU - Davis,S S, AU - Illum,L, PY - 1999/9/30/pubmed PY - 1999/9/30/medline PY - 1999/9/30/entrez SP - 53 EP - 65 JF - International journal of pharmaceutics JO - Int J Pharm VL - 187 IS - 1 N2 - Non-crosslinked and crosslinked chitosan microspheres were prepared by a spray drying method. The microspheres so prepared had a good sphericity and a smooth but distorted surface morphology. They were positively charged. The particle size ranged from 2 to 10 micron. The size and seta potential of the particles were influenced by the crosslinking level. With decreasing amount of crosslinking agent (either glutaraldehyde or formaldehyde), both particle size and zeta potential were increased. Preparation conditions also had some influence on the particle size. DSC studies revealed that the H2 antagonist drug cimetidine, as well as famotidine was molecularly dispersed inside the microspheres, in the form of a solid solution. The release of model drugs (cimetidine, famotidine and nizatidine) from these microspheres was fast, and accompanied by a burst effect. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/10502613/Chitosan_microspheres_prepared_by_spray_drying_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(99)00125-8 DB - PRIME DP - Unbound Medicine ER -