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Experimental rhinovirus 16 infection causes variable airway obstruction in subjects with atopic asthma.
Am J Respir Crit Care Med 1999; 160(4):1375-80AJ

Abstract

Exacerbations of asthma are often associated with rhinovirus infections. However, it has not been investigated whether rhinovirus infection can induce variable airway obstruction in asthma. We examined the effect of experimental rhinovirus 16 (RV16) infection on daily home recordings of FEV(1) in 27 subjects (nonsmoking, atopic, mildly asthmatic) who participated in a parallel placebo-controlled study. The subjects used a microspirometer to record FEV(1) three times daily from 4 d before until 10 d after RV16 (n = 19) or placebo (n = 8) inoculation. In addition, symptoms of asthma and symptoms of common cold were scored. Airway hyperresponsiveness to histamine was measured 3 d before and on Days 4 and 11 after RV16/placebo administration. Home recordings of FEV(1) decreased significantly after RV16 infection, reaching a minimum 2 d after inoculation (ANOVA, p </= 0.005), which was significantly different from placebo (p </= 0.004). In the RV16 group the lowest FEV(1) (expressed as a percentage of personal best) during Days 0-3 after infection (mean +/- SEM: 78.7 +/- 2.6% versus baseline: 85.6 +/- 1.2%, p = 0.008) correlated significantly with the cold score (r = -0.47, p = 0.04), asthma score (r = -0.47, p = 0.04), and with the decrease in airway hyperresponsiveness on Day 4 as compared with baseline (r = 0.50, p = 0.03). We conclude that experimental RV16 infection augments variable airway obstruction in subjects with asthma. This favors a causative role for rhinovirus colds in asthma exacerbations, and is in keeping with rhinovirus-induced worsening of airway inflammation.

Authors+Show Affiliations

Department of Pulmonology, Leiden University Medical Center (LUMC), Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10508832

Citation

Grünberg, K, et al. "Experimental Rhinovirus 16 Infection Causes Variable Airway Obstruction in Subjects With Atopic Asthma." American Journal of Respiratory and Critical Care Medicine, vol. 160, no. 4, 1999, pp. 1375-80.
Grünberg K, Timmers MC, de Klerk EP, et al. Experimental rhinovirus 16 infection causes variable airway obstruction in subjects with atopic asthma. Am J Respir Crit Care Med. 1999;160(4):1375-80.
Grünberg, K., Timmers, M. C., de Klerk, E. P., Dick, E. C., & Sterk, P. J. (1999). Experimental rhinovirus 16 infection causes variable airway obstruction in subjects with atopic asthma. American Journal of Respiratory and Critical Care Medicine, 160(4), pp. 1375-80.
Grünberg K, et al. Experimental Rhinovirus 16 Infection Causes Variable Airway Obstruction in Subjects With Atopic Asthma. Am J Respir Crit Care Med. 1999;160(4):1375-80. PubMed PMID: 10508832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental rhinovirus 16 infection causes variable airway obstruction in subjects with atopic asthma. AU - Grünberg,K, AU - Timmers,M C, AU - de Klerk,E P, AU - Dick,E C, AU - Sterk,P J, PY - 1999/10/6/pubmed PY - 1999/10/6/medline PY - 1999/10/6/entrez SP - 1375 EP - 80 JF - American journal of respiratory and critical care medicine JO - Am. J. Respir. Crit. Care Med. VL - 160 IS - 4 N2 - Exacerbations of asthma are often associated with rhinovirus infections. However, it has not been investigated whether rhinovirus infection can induce variable airway obstruction in asthma. We examined the effect of experimental rhinovirus 16 (RV16) infection on daily home recordings of FEV(1) in 27 subjects (nonsmoking, atopic, mildly asthmatic) who participated in a parallel placebo-controlled study. The subjects used a microspirometer to record FEV(1) three times daily from 4 d before until 10 d after RV16 (n = 19) or placebo (n = 8) inoculation. In addition, symptoms of asthma and symptoms of common cold were scored. Airway hyperresponsiveness to histamine was measured 3 d before and on Days 4 and 11 after RV16/placebo administration. Home recordings of FEV(1) decreased significantly after RV16 infection, reaching a minimum 2 d after inoculation (ANOVA, p </= 0.005), which was significantly different from placebo (p </= 0.004). In the RV16 group the lowest FEV(1) (expressed as a percentage of personal best) during Days 0-3 after infection (mean +/- SEM: 78.7 +/- 2.6% versus baseline: 85.6 +/- 1.2%, p = 0.008) correlated significantly with the cold score (r = -0.47, p = 0.04), asthma score (r = -0.47, p = 0.04), and with the decrease in airway hyperresponsiveness on Day 4 as compared with baseline (r = 0.50, p = 0.03). We conclude that experimental RV16 infection augments variable airway obstruction in subjects with asthma. This favors a causative role for rhinovirus colds in asthma exacerbations, and is in keeping with rhinovirus-induced worsening of airway inflammation. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/10508832/Experimental_rhinovirus_16_infection_causes_variable_airway_obstruction_in_subjects_with_atopic_asthma_ L2 - http://www.atsjournals.org/doi/full/10.1164/ajrccm.160.4.9810083?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -