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Biochemical markers of bone turnover in Paget's disease of bone.
J Bone Miner Res. 1999 Oct; 14 Suppl 2:66-9.JB

Abstract

Although the measurement of total alkaline phosphatase activity in serum is a valid index to assess the activity of Paget's disease of bone and to monitor treatment efficacy, this marker may lack sensitivity in some cases. Among the various markers of bone formation and resorption that have been developed, serum bone specific alkaline phosphatase and procollagen I N-terminal peptide (PINP) for formation, urinary N-telopeptide (NTX) and alpha-C-telopeptide (CTX) for bone resorption have emerged as the most sensitive ones, and may be useful in the management of pagetic patients. We have recently shown that the beta-isomerization of type I collagen CTX is impaired in pagetic bone matrix characterized by the existence of woven bone, as compared to normal lamellar bone matrix. This abnormality results in a preferential urinary excretion of nonisomerized (alpha-CTX) over beta-isomerized (beta-CTX) that can be measured with specific immunoassays. Patients with active Paget's disease of bone are characterized by an abnormally high alpha/beta-CTX ratio which goes down to the normal range after bisphosphonate therapy, probably reflecting the lamellar structure of newly formed bone matrix in pagetic skeletal sites after treatment.

Authors+Show Affiliations

INSERM Research Unit 403 and Claude Bernard University of Lyon, Lyon, France.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10510216

Citation

Delmas, P D.. "Biochemical Markers of Bone Turnover in Paget's Disease of Bone." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 14 Suppl 2, 1999, pp. 66-9.
Delmas PD. Biochemical markers of bone turnover in Paget's disease of bone. J Bone Miner Res. 1999;14 Suppl 2:66-9.
Delmas, P. D. (1999). Biochemical markers of bone turnover in Paget's disease of bone. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 14 Suppl 2, 66-9.
Delmas PD. Biochemical Markers of Bone Turnover in Paget's Disease of Bone. J Bone Miner Res. 1999;14 Suppl 2:66-9. PubMed PMID: 10510216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biochemical markers of bone turnover in Paget's disease of bone. A1 - Delmas,P D, PY - 1999/10/6/pubmed PY - 1999/10/6/medline PY - 1999/10/6/entrez SP - 66 EP - 9 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 14 Suppl 2 N2 - Although the measurement of total alkaline phosphatase activity in serum is a valid index to assess the activity of Paget's disease of bone and to monitor treatment efficacy, this marker may lack sensitivity in some cases. Among the various markers of bone formation and resorption that have been developed, serum bone specific alkaline phosphatase and procollagen I N-terminal peptide (PINP) for formation, urinary N-telopeptide (NTX) and alpha-C-telopeptide (CTX) for bone resorption have emerged as the most sensitive ones, and may be useful in the management of pagetic patients. We have recently shown that the beta-isomerization of type I collagen CTX is impaired in pagetic bone matrix characterized by the existence of woven bone, as compared to normal lamellar bone matrix. This abnormality results in a preferential urinary excretion of nonisomerized (alpha-CTX) over beta-isomerized (beta-CTX) that can be measured with specific immunoassays. Patients with active Paget's disease of bone are characterized by an abnormally high alpha/beta-CTX ratio which goes down to the normal range after bisphosphonate therapy, probably reflecting the lamellar structure of newly formed bone matrix in pagetic skeletal sites after treatment. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/10510216/Biochemical_markers_of_bone_turnover_in_Paget's_disease_of_bone_ L2 - https://doi.org/10.1002/jbmr.5650140213 DB - PRIME DP - Unbound Medicine ER -