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Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever.
J Infect Dis. 1999 Nov; 180(5):1429-35.JI

Abstract

Recent reports have demonstrated immune activation in dengue hemorrhagic fever (DHF) by cytokine and soluble receptor detection in blood. The goal of this study was to determine which cell types are activated and likely to be responsible for cytokine production. Whole blood specimens from 51 Thai children presenting within 72 h of fever onset and with detectable plasma dengue viral RNA were studied by flow cytometry. Absolute CD4 T cell, CD8 T cell, NK cell, and gammadelta T cell counts were decreased in children with DHF compared with those with dengue fever (DF) early in the course of illness. The percent of cells expressing CD69 was increased on CD8 T cells and NK cells in children who developed DHF more than in those with DF. These data directly demonstrate that cellular immune activation is present early in acute dengue and is related to disease severity.

Authors+Show Affiliations

Center for Infectious Disease, University of Massachusetts, Worcester, MA, USA. Sharne.Green@umassmed.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10515800

Citation

Green, S, et al. "Early CD69 Expression On Peripheral Blood Lymphocytes From Children With Dengue Hemorrhagic Fever." The Journal of Infectious Diseases, vol. 180, no. 5, 1999, pp. 1429-35.
Green S, Pichyangkul S, Vaughn DW, et al. Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever. J Infect Dis. 1999;180(5):1429-35.
Green, S., Pichyangkul, S., Vaughn, D. W., Kalayanarooj, S., Nimmannitya, S., Nisalak, A., Kurane, I., Rothman, A. L., & Ennis, F. A. (1999). Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever. The Journal of Infectious Diseases, 180(5), 1429-35.
Green S, et al. Early CD69 Expression On Peripheral Blood Lymphocytes From Children With Dengue Hemorrhagic Fever. J Infect Dis. 1999;180(5):1429-35. PubMed PMID: 10515800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever. AU - Green,S, AU - Pichyangkul,S, AU - Vaughn,D W, AU - Kalayanarooj,S, AU - Nimmannitya,S, AU - Nisalak,A, AU - Kurane,I, AU - Rothman,A L, AU - Ennis,F A, PY - 1999/10/9/pubmed PY - 2000/7/6/medline PY - 1999/10/9/entrez SP - 1429 EP - 35 JF - The Journal of infectious diseases JO - J Infect Dis VL - 180 IS - 5 N2 - Recent reports have demonstrated immune activation in dengue hemorrhagic fever (DHF) by cytokine and soluble receptor detection in blood. The goal of this study was to determine which cell types are activated and likely to be responsible for cytokine production. Whole blood specimens from 51 Thai children presenting within 72 h of fever onset and with detectable plasma dengue viral RNA were studied by flow cytometry. Absolute CD4 T cell, CD8 T cell, NK cell, and gammadelta T cell counts were decreased in children with DHF compared with those with dengue fever (DF) early in the course of illness. The percent of cells expressing CD69 was increased on CD8 T cells and NK cells in children who developed DHF more than in those with DF. These data directly demonstrate that cellular immune activation is present early in acute dengue and is related to disease severity. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10515800/Early_CD69_expression_on_peripheral_blood_lymphocytes_from_children_with_dengue_hemorrhagic_fever_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/315072 DB - PRIME DP - Unbound Medicine ER -