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Progressive expansion of an L-selectin-negative CD8 cell with anti-feline immunodeficiency virus (FIV) suppressor function in the circulation of FIV-infected cats.
J Infect Dis. 1999 Nov; 180(5):1503-13.JI

Abstract

The acute stage of feline immunodeficiency virus (FIV) infection is characterized by the appearance of a major CD8 subpopulation with reduced expression of the CD8 beta chain (CD8alpha+betalo). CD8 antiviral activity was subsequently shown to be mediated by the CD8alpha+betalo phenotype, which is the dominant CD8 phenotype in long-term infected cats. Two- and three-color flow cytometric analysis demonstrated that the CD8alpha+betalo subset is L-selectin negative (CD62L-) and has increased expression of CD44, CD49d, and CD18, consistent with an activation phenotype. The CD8alpha+betaloCD62L- cells but not the CD8alpha+betahiCD62L+ cells demonstrated strong antiviral activity in the FIV acute-infection assay. The progressive expansion of the CD8alpha+betaloCD62L- effector subset cells in FIV-infected cats parallels that seen in human immunodeficiency virus (HIV)-infected patients, suggesting that failure in homeostatic mechanisms regulating lymphocyte activation or trafficking (or both) may be a consequence of both HIV and FIV infections.

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Authors+Show Affiliations

Gebhard DH
Department of Microbiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
Dow JL
No affiliation info available
Childers TA
No affiliation info available
Alvelo JI
No affiliation info available
Tompkins MB
No affiliation info available
Tompkins WA
No affiliation info available

MeSH

AnimalsCD8-Positive T-LymphocytesCatsFeline Acquired Immunodeficiency SyndromeImmunodeficiency Virus, FelineImmunophenotypingIntegrinsL-SelectinLeukocytes, MononuclearLymph NodesT-Lymphocyte SubsetsT-Lymphocytes, Regulatory

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10515809

Citation

Gebhard, D H., et al. "Progressive Expansion of an L-selectin-negative CD8 Cell With Anti-feline Immunodeficiency Virus (FIV) Suppressor Function in the Circulation of FIV-infected Cats." The Journal of Infectious Diseases, vol. 180, no. 5, 1999, pp. 1503-13.
Gebhard DH, Dow JL, Childers TA, et al. Progressive expansion of an L-selectin-negative CD8 cell with anti-feline immunodeficiency virus (FIV) suppressor function in the circulation of FIV-infected cats. J Infect Dis. 1999;180(5):1503-13.
Gebhard, D. H., Dow, J. L., Childers, T. A., Alvelo, J. I., Tompkins, M. B., & Tompkins, W. A. (1999). Progressive expansion of an L-selectin-negative CD8 cell with anti-feline immunodeficiency virus (FIV) suppressor function in the circulation of FIV-infected cats. The Journal of Infectious Diseases, 180(5), 1503-13.
Gebhard DH, et al. Progressive Expansion of an L-selectin-negative CD8 Cell With Anti-feline Immunodeficiency Virus (FIV) Suppressor Function in the Circulation of FIV-infected Cats. J Infect Dis. 1999;180(5):1503-13. PubMed PMID: 10515809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progressive expansion of an L-selectin-negative CD8 cell with anti-feline immunodeficiency virus (FIV) suppressor function in the circulation of FIV-infected cats. AU - Gebhard,D H, AU - Dow,J L, AU - Childers,T A, AU - Alvelo,J I, AU - Tompkins,M B, AU - Tompkins,W A, PY - 1999/10/9/pubmed PY - 2000/7/6/medline PY - 1999/10/9/entrez SP - 1503 EP - 13 JF - The Journal of infectious diseases JO - J Infect Dis VL - 180 IS - 5 N2 - The acute stage of feline immunodeficiency virus (FIV) infection is characterized by the appearance of a major CD8 subpopulation with reduced expression of the CD8 beta chain (CD8alpha+betalo). CD8 antiviral activity was subsequently shown to be mediated by the CD8alpha+betalo phenotype, which is the dominant CD8 phenotype in long-term infected cats. Two- and three-color flow cytometric analysis demonstrated that the CD8alpha+betalo subset is L-selectin negative (CD62L-) and has increased expression of CD44, CD49d, and CD18, consistent with an activation phenotype. The CD8alpha+betaloCD62L- cells but not the CD8alpha+betahiCD62L+ cells demonstrated strong antiviral activity in the FIV acute-infection assay. The progressive expansion of the CD8alpha+betaloCD62L- effector subset cells in FIV-infected cats parallels that seen in human immunodeficiency virus (HIV)-infected patients, suggesting that failure in homeostatic mechanisms regulating lymphocyte activation or trafficking (or both) may be a consequence of both HIV and FIV infections. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10515809/Progressive_expansion_of_an_L_selectin_negative_CD8_cell_with_anti_feline_immunodeficiency_virus__FIV__suppressor_function_in_the_circulation_of_FIV_infected_cats_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/315089 DB - PRIME DP - Unbound Medicine ER -