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Fruit and vegetable intake in relation to risk of ischemic stroke.

Abstract

CONTEXT

Few studies have evaluated the relationship between fruit and vegetable intake and cardiovascular disease.

OBJECTIVE

To examine the associations between fruit and vegetable intake and ischemic stroke.

DESIGN, SETTING, AND SUBJECTS

Prospective cohort studies, including 75 596 women aged 34 to 59 years in the Nurses' Health Study with 14 years of follow-up (1980-1994), and 38683 men aged 40 to 75 years in the Health Professionals' Follow-up Study with 8 years of follow-up (1986-1994). All individuals were free of cardiovascular disease, cancer, and diabetes at baseline.

MAIN OUTCOME MEASURE

Incidence of ischemic stroke by quintile of fruit and vegetable intake.

RESULTS

A total of 366 women and 204 men had an ischemic stroke. After controlling for standard cardiovascular risk factors, persons in the highest quintile of fruit and vegetable intake (median of 5.1 servings per day among men and 5.8 servings per day among women) had a relative risk (RR) of 0.69 (95% confidence interval [CI], 0.52-0.92) compared with those in the lowest quintile. An increment of 1 serving per day of fruits or vegetables was associated with a 6% lower risk of ischemic stroke (RR, 0.94; 95 % CI, 0.90-0.99; P =.01, test for trend). Cruciferous vegetables (RR, 0.68 for an increment of 1 serving per day; 95% CI, 0.49-0.94), green leafy vegetables (RR, 0.79; 95% CI, 0.62-0.99), citrus fruit including juice (RR, 0.81; 95% CI, 0.68-0.96), and citrus fruit juice (RR, 0.75; 95% CI, 0.61-0.93) contributed most to the apparent protective effect of total fruits and vegetables. Legumes or potatoes were not associated with lower ischemic stroke risk. The multivariate pooled RR for total stroke was 0.96 (95% CI, 0.93-1.00) for each increment of 2 servings per day.

CONCLUSIONS

These data support a protective relationship between consumption of fruit and vegetables-particularly cruciferous and green leafy vegetables and citrus fruit and juice-and ischemic stroke risk.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Harvard School of Public Health, Boston, Mass, USA. hpkaj@gauss.med.harvard.edu

    , , , , , , ,

    Source

    JAMA 282:13 1999 Oct 06 pg 1233-9

    MeSH

    Adult
    Aged
    Brain Ischemia
    Citrus
    Cohort Studies
    Diet
    Female
    Follow-Up Studies
    Fruit
    Humans
    Incidence
    Male
    Middle Aged
    Multivariate Analysis
    Risk
    Risk Factors
    Surveys and Questionnaires
    United States
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10517425

    Citation

    Joshipura, K J., et al. "Fruit and Vegetable Intake in Relation to Risk of Ischemic Stroke." JAMA, vol. 282, no. 13, 1999, pp. 1233-9.
    Joshipura KJ, Ascherio A, Manson JE, et al. Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA. 1999;282(13):1233-9.
    Joshipura, K. J., Ascherio, A., Manson, J. E., Stampfer, M. J., Rimm, E. B., Speizer, F. E., ... Willett, W. C. (1999). Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA, 282(13), pp. 1233-9.
    Joshipura KJ, et al. Fruit and Vegetable Intake in Relation to Risk of Ischemic Stroke. JAMA. 1999 Oct 6;282(13):1233-9. PubMed PMID: 10517425.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fruit and vegetable intake in relation to risk of ischemic stroke. AU - Joshipura,K J, AU - Ascherio,A, AU - Manson,J E, AU - Stampfer,M J, AU - Rimm,E B, AU - Speizer,F E, AU - Hennekens,C H, AU - Spiegelman,D, AU - Willett,W C, PY - 1999/10/12/pubmed PY - 2001/8/14/medline PY - 1999/10/12/entrez SP - 1233 EP - 9 JF - JAMA JO - JAMA VL - 282 IS - 13 N2 - CONTEXT: Few studies have evaluated the relationship between fruit and vegetable intake and cardiovascular disease. OBJECTIVE: To examine the associations between fruit and vegetable intake and ischemic stroke. DESIGN, SETTING, AND SUBJECTS: Prospective cohort studies, including 75 596 women aged 34 to 59 years in the Nurses' Health Study with 14 years of follow-up (1980-1994), and 38683 men aged 40 to 75 years in the Health Professionals' Follow-up Study with 8 years of follow-up (1986-1994). All individuals were free of cardiovascular disease, cancer, and diabetes at baseline. MAIN OUTCOME MEASURE: Incidence of ischemic stroke by quintile of fruit and vegetable intake. RESULTS: A total of 366 women and 204 men had an ischemic stroke. After controlling for standard cardiovascular risk factors, persons in the highest quintile of fruit and vegetable intake (median of 5.1 servings per day among men and 5.8 servings per day among women) had a relative risk (RR) of 0.69 (95% confidence interval [CI], 0.52-0.92) compared with those in the lowest quintile. An increment of 1 serving per day of fruits or vegetables was associated with a 6% lower risk of ischemic stroke (RR, 0.94; 95 % CI, 0.90-0.99; P =.01, test for trend). Cruciferous vegetables (RR, 0.68 for an increment of 1 serving per day; 95% CI, 0.49-0.94), green leafy vegetables (RR, 0.79; 95% CI, 0.62-0.99), citrus fruit including juice (RR, 0.81; 95% CI, 0.68-0.96), and citrus fruit juice (RR, 0.75; 95% CI, 0.61-0.93) contributed most to the apparent protective effect of total fruits and vegetables. Legumes or potatoes were not associated with lower ischemic stroke risk. The multivariate pooled RR for total stroke was 0.96 (95% CI, 0.93-1.00) for each increment of 2 servings per day. CONCLUSIONS: These data support a protective relationship between consumption of fruit and vegetables-particularly cruciferous and green leafy vegetables and citrus fruit and juice-and ischemic stroke risk. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/10517425/Fruit_and_vegetable_intake_in_relation_to_risk_of_ischemic_stroke_ L2 - https://jamanetwork.com/journals/jama/fullarticle/vol/282/pg/1233 DB - PRIME DP - Unbound Medicine ER -