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Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes.
Ophthalmology 1999; 106(10):2027-32O

Abstract

PURPOSE

To evaluate optic disc and retinal nerve fiber layer (RNFL) appearance in normal, ocular-hypertensive, and glaucomatous eyes undergoing confocal scanning laser ophthalmoscopy and optical coherence tomography (OCT).

DESIGN

Prospective, cross-sectional study.

PARTICIPANTS

Seventy-eight eyes of 78 consecutive normal (n = 17), ocular-hypertensive (n = 23), and glaucomatous subjects (n = 38) were enrolled.

METHODS

Each patient underwent complete ophthalmic examination, achromatic automated perimetry, confocal scanning laser ophthalmoscopy (Heidelberg Retinal Tomography [HRT]), and OCT. Topographic HRT parameters (disc area, cup-disc ratio, rim area, rim volume, cup shape measure, mean RNFL thickness, and cross-sectional area) and mean OCT-generated RNFL thickness were evaluated in each group.

MAIN OUTCOME MEASURES

OCT and HRT assessment of optic disc and RNFL anatomy.

RESULTS

OCT RNFL thickness showed no difference between normal and ocular-hypertensive eyes (P = 0.15) but was significantly less in glaucomatous eyes (P < 0.001). HRT measurements of rim area, cup-disc ratio, cup shape measure, RNFL thickness, and RNFL cross-sectional area were significantly less in glaucomatous eyes (all P < 0.005) and were correlated with mean OCT RNFL thickness (all P < 0.02). RNFL thickness using OCT or HRT was highly correlated with visual field mean defect during achromatic perimetry (P < 0.0001).

CONCLUSION

Both HRT and OCT can differentiate glaucomatous from nonglaucomatous eyes. RNFL thickness measurements using OCT correspond to disc topographic parameters using HRT.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Mistlberger A
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York 10003, USA.
    Liebmann JM
    No affiliation info available
    Greenfield DS
    No affiliation info available
    Pons ME
    No affiliation info available
    Hoh ST
    No affiliation info available
    Ishikawa H
    No affiliation info available
    Ritch R
    No affiliation info available

    MeSH

    AdultAgedCross-Sectional StudiesFemaleGlaucomaHumansIntraocular PressureMaleMiddle AgedNerve FibersOcular HypertensionOphthalmoscopyOptic DiskOptic NerveProspective StudiesTomographyVisual Field TestsVisual Fields

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10519603

    Citation

    Mistlberger, A, et al. "Heidelberg Retina Tomography and Optical Coherence Tomography in Normal, Ocular-hypertensive, and Glaucomatous Eyes." Ophthalmology, vol. 106, no. 10, 1999, pp. 2027-32.
    Mistlberger A, Liebmann JM, Greenfield DS, et al. Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes. Ophthalmology. 1999;106(10):2027-32.
    Mistlberger, A., Liebmann, J. M., Greenfield, D. S., Pons, M. E., Hoh, S. T., Ishikawa, H., & Ritch, R. (1999). Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes. Ophthalmology, 106(10), pp. 2027-32.
    Mistlberger A, et al. Heidelberg Retina Tomography and Optical Coherence Tomography in Normal, Ocular-hypertensive, and Glaucomatous Eyes. Ophthalmology. 1999;106(10):2027-32. PubMed PMID: 10519603.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes. AU - Mistlberger,A, AU - Liebmann,J M, AU - Greenfield,D S, AU - Pons,M E, AU - Hoh,S T, AU - Ishikawa,H, AU - Ritch,R, PY - 1999/10/16/pubmed PY - 1999/10/16/medline PY - 1999/10/16/entrez SP - 2027 EP - 32 JF - Ophthalmology JO - Ophthalmology VL - 106 IS - 10 N2 - PURPOSE: To evaluate optic disc and retinal nerve fiber layer (RNFL) appearance in normal, ocular-hypertensive, and glaucomatous eyes undergoing confocal scanning laser ophthalmoscopy and optical coherence tomography (OCT). DESIGN: Prospective, cross-sectional study. PARTICIPANTS: Seventy-eight eyes of 78 consecutive normal (n = 17), ocular-hypertensive (n = 23), and glaucomatous subjects (n = 38) were enrolled. METHODS: Each patient underwent complete ophthalmic examination, achromatic automated perimetry, confocal scanning laser ophthalmoscopy (Heidelberg Retinal Tomography [HRT]), and OCT. Topographic HRT parameters (disc area, cup-disc ratio, rim area, rim volume, cup shape measure, mean RNFL thickness, and cross-sectional area) and mean OCT-generated RNFL thickness were evaluated in each group. MAIN OUTCOME MEASURES: OCT and HRT assessment of optic disc and RNFL anatomy. RESULTS: OCT RNFL thickness showed no difference between normal and ocular-hypertensive eyes (P = 0.15) but was significantly less in glaucomatous eyes (P < 0.001). HRT measurements of rim area, cup-disc ratio, cup shape measure, RNFL thickness, and RNFL cross-sectional area were significantly less in glaucomatous eyes (all P < 0.005) and were correlated with mean OCT RNFL thickness (all P < 0.02). RNFL thickness using OCT or HRT was highly correlated with visual field mean defect during achromatic perimetry (P < 0.0001). CONCLUSION: Both HRT and OCT can differentiate glaucomatous from nonglaucomatous eyes. RNFL thickness measurements using OCT correspond to disc topographic parameters using HRT. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/10519603/Heidelberg_retina_tomography_and_optical_coherence_tomography_in_normal_ocular_hypertensive_and_glaucomatous_eyes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(99)90419-0 DB - PRIME DP - Unbound Medicine ER -