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Time course of symptomatic orthostatic hypotension and urinary incontinence in patients with postmortem confirmed parkinsonian syndromes: a clinicopathological study.
J Neurol Neurosurg Psychiatry. 1999 Nov; 67(5):620-3.JN

Abstract

OBJECTIVE

Although both orthostatic hypotension and urinary incontinence have been reported in a number of parkinsonian syndromes, such as Parkinson's disease (PD), multiple system atrophy (MSA), dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), differences in the evolution of these features have not been studied systematically in pathologically confirmed cases.

METHODS

77 cases with pathologically confirmed parkinsonian syndromes (PD, n=11; MSA, n=15; DLB, n=14; CBD, n=13; PSP, n=24), collected up to 1994, formed the basis for a multicentre clinicopathological study organised by the NINDS to improve the differential diagnosis of parkinsonian disorders. The present study determined the time course-that is, latency to onset and duration from onset to death, of symptomatic orthostatic hypotension, and urinary incontinence in the NINDS series. Furthermore, the diagnostic validity of a predefined latency to onset within 1 year of disease onset of symptomatic orthostatic hypotension or urinary incontinence was analysed.

RESULTS

Significant group differences for latency, but not duration, of symptomatic orthostatic hypotension and urinary incontinence were found. Latencies to onset of either feature were short in patients with MSA, intermediate in patients with DLB, CBD, and PSP, and long in those with PD. Symptomatic orthostatic hypotension occurring within the first year after disease onset predicted MSA in 75% of cases; early urinary incontinence was less predictive for MSA (56%).

CONCLUSION

Latency to onset, but not duration, of symptomatic orthostatic hypotension or urinary incontinence differentiates PD from other parkinsonian syndromes, particularly MSA.

Authors+Show Affiliations

Department of Neurology, University Hospital, Innsbruck, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10519868

Citation

Wenning, G K., et al. "Time Course of Symptomatic Orthostatic Hypotension and Urinary Incontinence in Patients With Postmortem Confirmed Parkinsonian Syndromes: a Clinicopathological Study." Journal of Neurology, Neurosurgery, and Psychiatry, vol. 67, no. 5, 1999, pp. 620-3.
Wenning GK, Scherfler C, Granata R, et al. Time course of symptomatic orthostatic hypotension and urinary incontinence in patients with postmortem confirmed parkinsonian syndromes: a clinicopathological study. J Neurol Neurosurg Psychiatry. 1999;67(5):620-3.
Wenning, G. K., Scherfler, C., Granata, R., Bösch, S., Verny, M., Chaudhuri, K. R., Jellinger, K., Poewe, W., & Litvan, I. (1999). Time course of symptomatic orthostatic hypotension and urinary incontinence in patients with postmortem confirmed parkinsonian syndromes: a clinicopathological study. Journal of Neurology, Neurosurgery, and Psychiatry, 67(5), 620-3.
Wenning GK, et al. Time Course of Symptomatic Orthostatic Hypotension and Urinary Incontinence in Patients With Postmortem Confirmed Parkinsonian Syndromes: a Clinicopathological Study. J Neurol Neurosurg Psychiatry. 1999;67(5):620-3. PubMed PMID: 10519868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Time course of symptomatic orthostatic hypotension and urinary incontinence in patients with postmortem confirmed parkinsonian syndromes: a clinicopathological study. AU - Wenning,G K, AU - Scherfler,C, AU - Granata,R, AU - Bösch,S, AU - Verny,M, AU - Chaudhuri,K R, AU - Jellinger,K, AU - Poewe,W, AU - Litvan,I, PY - 1999/10/16/pubmed PY - 1999/10/16/medline PY - 1999/10/16/entrez SP - 620 EP - 3 JF - Journal of neurology, neurosurgery, and psychiatry JO - J Neurol Neurosurg Psychiatry VL - 67 IS - 5 N2 - OBJECTIVE: Although both orthostatic hypotension and urinary incontinence have been reported in a number of parkinsonian syndromes, such as Parkinson's disease (PD), multiple system atrophy (MSA), dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), differences in the evolution of these features have not been studied systematically in pathologically confirmed cases. METHODS: 77 cases with pathologically confirmed parkinsonian syndromes (PD, n=11; MSA, n=15; DLB, n=14; CBD, n=13; PSP, n=24), collected up to 1994, formed the basis for a multicentre clinicopathological study organised by the NINDS to improve the differential diagnosis of parkinsonian disorders. The present study determined the time course-that is, latency to onset and duration from onset to death, of symptomatic orthostatic hypotension, and urinary incontinence in the NINDS series. Furthermore, the diagnostic validity of a predefined latency to onset within 1 year of disease onset of symptomatic orthostatic hypotension or urinary incontinence was analysed. RESULTS: Significant group differences for latency, but not duration, of symptomatic orthostatic hypotension and urinary incontinence were found. Latencies to onset of either feature were short in patients with MSA, intermediate in patients with DLB, CBD, and PSP, and long in those with PD. Symptomatic orthostatic hypotension occurring within the first year after disease onset predicted MSA in 75% of cases; early urinary incontinence was less predictive for MSA (56%). CONCLUSION: Latency to onset, but not duration, of symptomatic orthostatic hypotension or urinary incontinence differentiates PD from other parkinsonian syndromes, particularly MSA. SN - 0022-3050 UR - https://www.unboundmedicine.com/medline/citation/10519868/Time_course_of_symptomatic_orthostatic_hypotension_and_urinary_incontinence_in_patients_with_postmortem_confirmed_parkinsonian_syndromes:_a_clinicopathological_study_ L2 - https://jnnp.bmj.com/lookup/pmidlookup?view=long&pmid=10519868 DB - PRIME DP - Unbound Medicine ER -