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Eosinophil protein X and eosinophil cationic protein as indicators of intestinal inflammation in infants with atopic eczema and food allergy.

Abstract

BACKGROUND

The aim of this study was to evaluate the presence of allergic intestinal inflammation in infants with food allergy and atopic eczema before and after elimination diet, and to evaluate the use of eosinophil protein X (EPX) and eosinophil cationic protein (ECP) in the monitoring of inflammatory activity.

METHODS

The study material comprised 25 infants with atopic dermatitis and food allergy. Thirteen healthy infants served as controls. Faecal and serum samples were collected before an elimination diet (on the first visit to the hospital) and approximately 3 months later for the determination of EPX and ECP.

RESULTS

Before the elimination diet, infants with atopic dermatitis demonstrated markedly higher faecal concentrations of EPX and ECP than healthy controls (P = 0. 0003, P < 0.0001, respectively). The faecal concentrations of EPX and ECP showed a distinct decrease as a result of an adequate elimination diet in patients with favourable clinical response (P = 0.0027, P = 0.004, respectively).

CONCLUSIONS

The results indicate the presence of marked intestinal inflammation in patients with atopic dermatitis and food allergy. The determination of faecal ECP and especially of faecal EPX provides a promising noninvasive tool in monitoring intestinal inflammation and disease activity in infants with atopic eczema and food allergy.

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  • Authors+Show Affiliations

    ,

    Medical School, University of Tampere, Finland.

    ,

    Source

    MeSH

    Biomarkers
    Blood Proteins
    Dermatitis, Atopic
    Diet
    Eosinophil Granule Proteins
    Eosinophil-Derived Neurotoxin
    Eosinophils
    Feces
    Food Hypersensitivity
    Humans
    Infant
    Inflammation
    Intestines
    Ribonucleases

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    10520078

    Citation

    Majamaa, H, et al. "Eosinophil Protein X and Eosinophil Cationic Protein as Indicators of Intestinal Inflammation in Infants With Atopic Eczema and Food Allergy." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 29, no. 11, 1999, pp. 1502-6.
    Majamaa H, Laine S, Miettinen A. Eosinophil protein X and eosinophil cationic protein as indicators of intestinal inflammation in infants with atopic eczema and food allergy. Clin Exp Allergy. 1999;29(11):1502-6.
    Majamaa, H., Laine, S., & Miettinen, A. (1999). Eosinophil protein X and eosinophil cationic protein as indicators of intestinal inflammation in infants with atopic eczema and food allergy. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 29(11), pp. 1502-6.
    Majamaa H, Laine S, Miettinen A. Eosinophil Protein X and Eosinophil Cationic Protein as Indicators of Intestinal Inflammation in Infants With Atopic Eczema and Food Allergy. Clin Exp Allergy. 1999;29(11):1502-6. PubMed PMID: 10520078.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Eosinophil protein X and eosinophil cationic protein as indicators of intestinal inflammation in infants with atopic eczema and food allergy. AU - Majamaa,H, AU - Laine,S, AU - Miettinen,A, PY - 1999/10/16/pubmed PY - 1999/10/16/medline PY - 1999/10/16/entrez SP - 1502 EP - 6 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 29 IS - 11 N2 - BACKGROUND: The aim of this study was to evaluate the presence of allergic intestinal inflammation in infants with food allergy and atopic eczema before and after elimination diet, and to evaluate the use of eosinophil protein X (EPX) and eosinophil cationic protein (ECP) in the monitoring of inflammatory activity. METHODS: The study material comprised 25 infants with atopic dermatitis and food allergy. Thirteen healthy infants served as controls. Faecal and serum samples were collected before an elimination diet (on the first visit to the hospital) and approximately 3 months later for the determination of EPX and ECP. RESULTS: Before the elimination diet, infants with atopic dermatitis demonstrated markedly higher faecal concentrations of EPX and ECP than healthy controls (P = 0. 0003, P < 0.0001, respectively). The faecal concentrations of EPX and ECP showed a distinct decrease as a result of an adequate elimination diet in patients with favourable clinical response (P = 0.0027, P = 0.004, respectively). CONCLUSIONS: The results indicate the presence of marked intestinal inflammation in patients with atopic dermatitis and food allergy. The determination of faecal ECP and especially of faecal EPX provides a promising noninvasive tool in monitoring intestinal inflammation and disease activity in infants with atopic eczema and food allergy. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/10520078/Eosinophil_protein_X_and_eosinophil_cationic_protein_as_indicators_of_intestinal_inflammation_in_infants_with_atopic_eczema_and_food_allergy_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0954-7894&amp;date=1999&amp;volume=29&amp;issue=11&amp;spage=1502 DB - PRIME DP - Unbound Medicine ER -