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The effect of pentoxifylline ('Trental') on cerebral blood flow: a double-blind study.
Curr Med Res Opin 1976-1977; 4(10):681-7CM

Abstract

A double-blind, placebo controlled crossover study was carried out in 20 geriatric patients with cerebrovascular insufficiency ot asses the effect of pentoxifylline on cerebral blood flow. Using 99m Tc cerebral scinitigraphy and a gamma comera/computer system, the pattern of blood flow in 5 brain areas was manitored after a single intravenous infusion of 200 mg pentoxifylline (10 ml) and after 10 ml saline solution. The results showed that, with the exception of one brain area, there was a statistically significant increase both in regional and hemispheric cerebral blood flow after pentoxifylline. It is of particular interst that global hemispheric blood flow, which gives an indication of total blood supply to the brain, showed approximately the same percentage increase on both sides with pentoxifylline.

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1052162

Citation

Koppenhagen, K, et al. "The Effect of Pentoxifylline ('Trental') On Cerebral Blood Flow: a Double-blind Study." Current Medical Research and Opinion, vol. 4, no. 10, 1977, pp. 681-7.
Koppenhagen K, Wenig HG, Müller K. The effect of pentoxifylline ('Trental') on cerebral blood flow: a double-blind study. Curr Med Res Opin. 1977;4(10):681-7.
Koppenhagen, K., Wenig, H. G., & Müller, K. (1977). The effect of pentoxifylline ('Trental') on cerebral blood flow: a double-blind study. Current Medical Research and Opinion, 4(10), pp. 681-7.
Koppenhagen K, Wenig HG, Müller K. The Effect of Pentoxifylline ('Trental') On Cerebral Blood Flow: a Double-blind Study. Curr Med Res Opin. 1977;4(10):681-7. PubMed PMID: 1052162.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of pentoxifylline ('Trental') on cerebral blood flow: a double-blind study. AU - Koppenhagen,K, AU - Wenig,H G, AU - Müller,K, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 681 EP - 7 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 4 IS - 10 N2 - A double-blind, placebo controlled crossover study was carried out in 20 geriatric patients with cerebrovascular insufficiency ot asses the effect of pentoxifylline on cerebral blood flow. Using 99m Tc cerebral scinitigraphy and a gamma comera/computer system, the pattern of blood flow in 5 brain areas was manitored after a single intravenous infusion of 200 mg pentoxifylline (10 ml) and after 10 ml saline solution. The results showed that, with the exception of one brain area, there was a statistically significant increase both in regional and hemispheric cerebral blood flow after pentoxifylline. It is of particular interst that global hemispheric blood flow, which gives an indication of total blood supply to the brain, showed approximately the same percentage increase on both sides with pentoxifylline. SN - 0300-7995 UR - https://www.unboundmedicine.com/medline/citation/1052162/The_effect_of_pentoxifylline__'Trental'__on_cerebral_blood_flow:_a_double_blind_study_ DB - PRIME DP - Unbound Medicine ER -