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Differences in the effect of iron-deficient diet on tissue weight, hemoglobin concentration and serum triglycerides in Fischer-344, Sprague-Dawley and Wistar rats.

Abstract

This study was designed to examine the differences in the effect of an iron-deficient diet on iron metabolism in Fischer-344 (FC), Sprague-Dawley (SD) and Wistar (WT) rats based on hemoglobin (Hb), hematocrit (Hct), serum iron levels, growth rate and organ weight. Hb concentration was higher in FC rats (14 mg/100 mL) on the initial day than in SD (10) and WT (10) rats. Although the Hb level was significantly decreased in FC rats fed an iron-deficient (ID, 8 mg/kg) diet for 33 d compared to the FC rats fed an iron-adequate (IA, 50 mg/kg) diet, the relative concentration of Hb was high in FC rats fed the ID diet as compared to the SD and WT rats fed the same diet. A similar relationship was detected between Hct and serum iron concentrations. Although serum triglycerides (TG) were significantly increased in each rat strain fed the ID diet as compared to the IA diet, the percentage of the value for the IA diet was lowest in FC rats (119%) fed the ID diet as compared to the SD (328) and WT (394) rats fed the same diet. Retroperitoneal fat pad was decreased in FC, SD and WT rats fed the ID diet as compared to the IA diet. SD rats were particularly sensitive to the reduction of retroperitoneal fat pad. The results suggested that rat strains responded differently to dietary iron inadequacy, and that FC rats were less sensitive to an iron-deficient diet as compared to the SD and WT rats.

Authors+Show Affiliations

,

Department of Public Health, Kumamoto University School of Medicine, Japan.

,

Source

MeSH

Adipose Tissue
Animal Nutritional Physiological Phenomena
Animals
Eating
Heart
Hematocrit
Hemoglobins
Iron
Iron, Dietary
Liver
Male
Organ Size
Rats
Rats, Inbred F344
Rats, Sprague-Dawley
Rats, Wistar
Spleen
Triglycerides
Weight Gain

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10524355

Citation

Kasaoka, S, et al. "Differences in the Effect of Iron-deficient Diet On Tissue Weight, Hemoglobin Concentration and Serum Triglycerides in Fischer-344, Sprague-Dawley and Wistar Rats." Journal of Nutritional Science and Vitaminology, vol. 45, no. 3, 1999, pp. 359-66.
Kasaoka S, Yamagishi H, Kitano T. Differences in the effect of iron-deficient diet on tissue weight, hemoglobin concentration and serum triglycerides in Fischer-344, Sprague-Dawley and Wistar rats. J Nutr Sci Vitaminol. 1999;45(3):359-66.
Kasaoka, S., Yamagishi, H., & Kitano, T. (1999). Differences in the effect of iron-deficient diet on tissue weight, hemoglobin concentration and serum triglycerides in Fischer-344, Sprague-Dawley and Wistar rats. Journal of Nutritional Science and Vitaminology, 45(3), pp. 359-66.
Kasaoka S, Yamagishi H, Kitano T. Differences in the Effect of Iron-deficient Diet On Tissue Weight, Hemoglobin Concentration and Serum Triglycerides in Fischer-344, Sprague-Dawley and Wistar Rats. J Nutr Sci Vitaminol. 1999;45(3):359-66. PubMed PMID: 10524355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in the effect of iron-deficient diet on tissue weight, hemoglobin concentration and serum triglycerides in Fischer-344, Sprague-Dawley and Wistar rats. AU - Kasaoka,S, AU - Yamagishi,H, AU - Kitano,T, PY - 1999/10/19/pubmed PY - 1999/10/19/medline PY - 1999/10/19/entrez SP - 359 EP - 66 JF - Journal of nutritional science and vitaminology JO - J. Nutr. Sci. Vitaminol. VL - 45 IS - 3 N2 - This study was designed to examine the differences in the effect of an iron-deficient diet on iron metabolism in Fischer-344 (FC), Sprague-Dawley (SD) and Wistar (WT) rats based on hemoglobin (Hb), hematocrit (Hct), serum iron levels, growth rate and organ weight. Hb concentration was higher in FC rats (14 mg/100 mL) on the initial day than in SD (10) and WT (10) rats. Although the Hb level was significantly decreased in FC rats fed an iron-deficient (ID, 8 mg/kg) diet for 33 d compared to the FC rats fed an iron-adequate (IA, 50 mg/kg) diet, the relative concentration of Hb was high in FC rats fed the ID diet as compared to the SD and WT rats fed the same diet. A similar relationship was detected between Hct and serum iron concentrations. Although serum triglycerides (TG) were significantly increased in each rat strain fed the ID diet as compared to the IA diet, the percentage of the value for the IA diet was lowest in FC rats (119%) fed the ID diet as compared to the SD (328) and WT (394) rats fed the same diet. Retroperitoneal fat pad was decreased in FC, SD and WT rats fed the ID diet as compared to the IA diet. SD rats were particularly sensitive to the reduction of retroperitoneal fat pad. The results suggested that rat strains responded differently to dietary iron inadequacy, and that FC rats were less sensitive to an iron-deficient diet as compared to the SD and WT rats. SN - 0301-4800 UR - https://www.unboundmedicine.com/medline/citation/10524355/Differences_in_the_effect_of_iron_deficient_diet_on_tissue_weight_hemoglobin_concentration_and_serum_triglycerides_in_Fischer_344_Sprague_Dawley_and_Wistar_rats_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -