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Immunohistological study endothelin-1 and endothelin-A and B receptors in two patients with scleroderma renal crisis.
Clin Rheumatol. 1999; 18(5):425-7.CR

Abstract

Scleroderma renal crisis (SRC) developed in two patients with systemic sclerosis (SSc) and they died from respiratory failure. Findings on autopsy revealed congestion and oedema in both lungs and intimal thickening of the small renal arteries in both patients. Immunohistological investigations showed positive staining of anti-human endothelin (ET)-1 in the media of the small renal arteries and ET-B receptor in the medial smooth muscle of the small renal arteries. This observation suggests an important pathophysiological role of ET-1 in the development of SRC in some patients with SSc.

Authors+Show Affiliations

Department of Internal Medicine II, School of Medicine, Fukushima Medical University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10524561

Citation

Kobayashi, H, et al. "Immunohistological Study Endothelin-1 and endothelin-A and B Receptors in Two Patients With Scleroderma Renal Crisis." Clinical Rheumatology, vol. 18, no. 5, 1999, pp. 425-7.
Kobayashi H, Nishimaki T, Kaise S, et al. Immunohistological study endothelin-1 and endothelin-A and B receptors in two patients with scleroderma renal crisis. Clin Rheumatol. 1999;18(5):425-7.
Kobayashi, H., Nishimaki, T., Kaise, S., Suzuki, T., Watanabe, K., Kasukawa, R., & Suzuki, T. (1999). Immunohistological study endothelin-1 and endothelin-A and B receptors in two patients with scleroderma renal crisis. Clinical Rheumatology, 18(5), 425-7.
Kobayashi H, et al. Immunohistological Study Endothelin-1 and endothelin-A and B Receptors in Two Patients With Scleroderma Renal Crisis. Clin Rheumatol. 1999;18(5):425-7. PubMed PMID: 10524561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunohistological study endothelin-1 and endothelin-A and B receptors in two patients with scleroderma renal crisis. AU - Kobayashi,H, AU - Nishimaki,T, AU - Kaise,S, AU - Suzuki,T, AU - Watanabe,K, AU - Kasukawa,R, AU - Suzuki,T, PY - 1999/10/19/pubmed PY - 1999/10/19/medline PY - 1999/10/19/entrez SP - 425 EP - 7 JF - Clinical rheumatology JO - Clin. Rheumatol. VL - 18 IS - 5 N2 - Scleroderma renal crisis (SRC) developed in two patients with systemic sclerosis (SSc) and they died from respiratory failure. Findings on autopsy revealed congestion and oedema in both lungs and intimal thickening of the small renal arteries in both patients. Immunohistological investigations showed positive staining of anti-human endothelin (ET)-1 in the media of the small renal arteries and ET-B receptor in the medial smooth muscle of the small renal arteries. This observation suggests an important pathophysiological role of ET-1 in the development of SRC in some patients with SSc. SN - 0770-3198 UR - https://www.unboundmedicine.com/medline/citation/10524561/Immunohistological_study_endothelin_1_and_endothelin_A_and_B_receptors_in_two_patients_with_scleroderma_renal_crisis_ L2 - http://www.diseaseinfosearch.org/result/6459 DB - PRIME DP - Unbound Medicine ER -