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Investigating the fundamental effects of binders on pharmaceutical tablet performance.
Drug Dev Ind Pharm. 1999 Oct; 25(10):1129-35.DD

Abstract

For solid dosage forms, a better understanding of the fundamental properties of the binders helps in developing better formulations and products. The objective of this study was to determine the effects of binder toughness and plastic flow on tablet hardness, friability, and capping. The characteristic of binder toughness was determined, and the correlation between the ejection force of the tablet and the toughness of the binder was established. Evaluation was conducted using acetaminophen tablets with different kinds of binders (i.e., hydroxypropylcellulose, methylcellulose [MC], povidone [PVP], starch, etc.). A rotary tablet press was used for tableting at three different speeds. The properties of binders and acetaminophen tablets were determined using a diametral compression test. The toughness was measured as the curve of the area under the load versus deflection. The microbehavior of these binders was also studied. The acetaminophen tablets with the binders were subjected to predetermined loads and then examined under a scanning electron microscope. The tablets that contained hydroxypropylcellulose as a binder showed the highest toughness and had the lowest ejection force. The ejection force of tablets decreased with increasing concentrations of hydroxypropylcellulose in the dosage forms. The tablets that contained other binders failed by capping and random cracking in the middle. These results show that hydroxypropylcellulose, a thermoplastic polymer, provides the best physical characteristics for the tablets. This effect could help in improving tablet manufacturing conditions (e.g., compression force and speed).

Authors+Show Affiliations

Joneja SK
Hercules Incorporated, Wilmington, DE 19808-1599, USA.
Harcum WW
No affiliation info available
Skinner GW
No affiliation info available
Barnum PE
No affiliation info available
Guo JH
No affiliation info available

MeSH

AcetaminophenChemistry, PharmaceuticalCompressive StrengthExcipientsHardnessMethylcelluloseMicroscopy, Electron, ScanningPlasticsPovidoneStarchTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10529894

Citation

Joneja, S K., et al. "Investigating the Fundamental Effects of Binders On Pharmaceutical Tablet Performance." Drug Development and Industrial Pharmacy, vol. 25, no. 10, 1999, pp. 1129-35.
Joneja SK, Harcum WW, Skinner GW, et al. Investigating the fundamental effects of binders on pharmaceutical tablet performance. Drug Dev Ind Pharm. 1999;25(10):1129-35.
Joneja, S. K., Harcum, W. W., Skinner, G. W., Barnum, P. E., & Guo, J. H. (1999). Investigating the fundamental effects of binders on pharmaceutical tablet performance. Drug Development and Industrial Pharmacy, 25(10), 1129-35.
Joneja SK, et al. Investigating the Fundamental Effects of Binders On Pharmaceutical Tablet Performance. Drug Dev Ind Pharm. 1999;25(10):1129-35. PubMed PMID: 10529894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigating the fundamental effects of binders on pharmaceutical tablet performance. AU - Joneja,S K, AU - Harcum,W W, AU - Skinner,G W, AU - Barnum,P E, AU - Guo,J H, PY - 1999/10/26/pubmed PY - 1999/10/26/medline PY - 1999/10/26/entrez SP - 1129 EP - 35 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 25 IS - 10 N2 - For solid dosage forms, a better understanding of the fundamental properties of the binders helps in developing better formulations and products. The objective of this study was to determine the effects of binder toughness and plastic flow on tablet hardness, friability, and capping. The characteristic of binder toughness was determined, and the correlation between the ejection force of the tablet and the toughness of the binder was established. Evaluation was conducted using acetaminophen tablets with different kinds of binders (i.e., hydroxypropylcellulose, methylcellulose [MC], povidone [PVP], starch, etc.). A rotary tablet press was used for tableting at three different speeds. The properties of binders and acetaminophen tablets were determined using a diametral compression test. The toughness was measured as the curve of the area under the load versus deflection. The microbehavior of these binders was also studied. The acetaminophen tablets with the binders were subjected to predetermined loads and then examined under a scanning electron microscope. The tablets that contained hydroxypropylcellulose as a binder showed the highest toughness and had the lowest ejection force. The ejection force of tablets decreased with increasing concentrations of hydroxypropylcellulose in the dosage forms. The tablets that contained other binders failed by capping and random cracking in the middle. These results show that hydroxypropylcellulose, a thermoplastic polymer, provides the best physical characteristics for the tablets. This effect could help in improving tablet manufacturing conditions (e.g., compression force and speed). SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/10529894/Investigating_the_fundamental_effects_of_binders_on_pharmaceutical_tablet_performance_ DB - PRIME DP - Unbound Medicine ER -