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Diet and risk of colorectal cancer in a cohort of Finnish men.
Cancer Causes Control 1999; 10(5):387-96CC

Abstract

OBJECTIVES

Based on previous epidemiological studies, high fat and meat consumption may increase and fiber, calcium, and vegetable consumption may decrease the risk of colorectal cancer. We sought to address these hypotheses in a male Finnish cohort.

METHODS

We analyzed data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC Study) where 27, 111 male smokers completed a validated dietary questionnaire at baseline. After an average of 8 years of follow-up, we documented 185 cases of colorectal cancer. The analyses were carried out using the Cox proportional hazards model.

RESULTS

The relative risk (RR) for men in the highest quartile of calcium intake compared with men in the lowest quartile was 0.6 (95% CI 0.4-0.9, p for trend 0.04). Likewise, the intake of milk protein and the consumption of milk products was inversely associated with risk of colorectal cancer. However, intake of dietary fiber was not associated with risk, nor was fat intake. Consumption of meat or different types of meat, and fried meat, fruits or vegetables were not associated with risk.

CONCLUSIONS

In this cohort of men consuming a diet high in fat, meat, and fiber and low in vegetables, high calcium intake was associated with lowered risk of colorectal cancer.

Authors+Show Affiliations

Department of Nutrition, National Public Health Institute, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10530608

Citation

Pietinen, P, et al. "Diet and Risk of Colorectal Cancer in a Cohort of Finnish Men." Cancer Causes & Control : CCC, vol. 10, no. 5, 1999, pp. 387-96.
Pietinen P, Malila N, Virtanen M, et al. Diet and risk of colorectal cancer in a cohort of Finnish men. Cancer Causes Control. 1999;10(5):387-96.
Pietinen, P., Malila, N., Virtanen, M., Hartman, T. J., Tangrea, J. A., Albanes, D., & Virtamo, J. (1999). Diet and risk of colorectal cancer in a cohort of Finnish men. Cancer Causes & Control : CCC, 10(5), pp. 387-96.
Pietinen P, et al. Diet and Risk of Colorectal Cancer in a Cohort of Finnish Men. Cancer Causes Control. 1999;10(5):387-96. PubMed PMID: 10530608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet and risk of colorectal cancer in a cohort of Finnish men. AU - Pietinen,P, AU - Malila,N, AU - Virtanen,M, AU - Hartman,T J, AU - Tangrea,J A, AU - Albanes,D, AU - Virtamo,J, PY - 1999/10/26/pubmed PY - 1999/10/26/medline PY - 1999/10/26/entrez SP - 387 EP - 96 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 10 IS - 5 N2 - OBJECTIVES: Based on previous epidemiological studies, high fat and meat consumption may increase and fiber, calcium, and vegetable consumption may decrease the risk of colorectal cancer. We sought to address these hypotheses in a male Finnish cohort. METHODS: We analyzed data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC Study) where 27, 111 male smokers completed a validated dietary questionnaire at baseline. After an average of 8 years of follow-up, we documented 185 cases of colorectal cancer. The analyses were carried out using the Cox proportional hazards model. RESULTS: The relative risk (RR) for men in the highest quartile of calcium intake compared with men in the lowest quartile was 0.6 (95% CI 0.4-0.9, p for trend 0.04). Likewise, the intake of milk protein and the consumption of milk products was inversely associated with risk of colorectal cancer. However, intake of dietary fiber was not associated with risk, nor was fat intake. Consumption of meat or different types of meat, and fried meat, fruits or vegetables were not associated with risk. CONCLUSIONS: In this cohort of men consuming a diet high in fat, meat, and fiber and low in vegetables, high calcium intake was associated with lowered risk of colorectal cancer. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/10530608/Diet_and_risk_of_colorectal_cancer_in_a_cohort_of_Finnish_men_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10530608.ui DB - PRIME DP - Unbound Medicine ER -