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Use of new antiepileptic drugs in the treatment of childhood epilepsy.
Epilepsia. 1999; 40 Suppl 6:S29-38; discussion S73-4.E

Abstract

The management of epilepsy in children requires careful evaluation, classification, and pharmacologic treatment. With classic antiepileptic drugs (AEDs), at least 25% of children remain refractory to appropriate therapy. The past decade has allowed the introduction of a number of newer AEDs for treatment of both adults and children with epilepsy. These include felbamate, gabapentin, lamotrigine, topiramate, tiagabine, and vigabatrin. Emerging information regarding the efficacy of these AEDs in treating childhood epilepsy syndromes suggests advantages for many patients. Limited data are available that define the optimal use of new AEDs in pediatric patients. Further research must be completed to validate the positive effects described in existing clinical trials of the new AEDs in the treatment of childhood epilepsy.

Authors+Show Affiliations

Division of Child Neurology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0211, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10530681

Citation

Pellock, J M., and R Appleton. "Use of New Antiepileptic Drugs in the Treatment of Childhood Epilepsy." Epilepsia, vol. 40 Suppl 6, 1999, pp. S29-38; discussion S73-4.
Pellock JM, Appleton R. Use of new antiepileptic drugs in the treatment of childhood epilepsy. Epilepsia. 1999;40 Suppl 6:S29-38; discussion S73-4.
Pellock, J. M., & Appleton, R. (1999). Use of new antiepileptic drugs in the treatment of childhood epilepsy. Epilepsia, 40 Suppl 6, S29-38; discussion S73-4.
Pellock JM, Appleton R. Use of New Antiepileptic Drugs in the Treatment of Childhood Epilepsy. Epilepsia. 1999;40 Suppl 6:S29-38; discussion S73-4. PubMed PMID: 10530681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of new antiepileptic drugs in the treatment of childhood epilepsy. AU - Pellock,J M, AU - Appleton,R, PY - 1999/10/26/pubmed PY - 1999/10/26/medline PY - 1999/10/26/entrez SP - S29-38; discussion S73-4 JF - Epilepsia JO - Epilepsia VL - 40 Suppl 6 N2 - The management of epilepsy in children requires careful evaluation, classification, and pharmacologic treatment. With classic antiepileptic drugs (AEDs), at least 25% of children remain refractory to appropriate therapy. The past decade has allowed the introduction of a number of newer AEDs for treatment of both adults and children with epilepsy. These include felbamate, gabapentin, lamotrigine, topiramate, tiagabine, and vigabatrin. Emerging information regarding the efficacy of these AEDs in treating childhood epilepsy syndromes suggests advantages for many patients. Limited data are available that define the optimal use of new AEDs in pediatric patients. Further research must be completed to validate the positive effects described in existing clinical trials of the new AEDs in the treatment of childhood epilepsy. SN - 0013-9580 UR - https://www.unboundmedicine.com/medline/citation/10530681/Use_of_new_antiepileptic_drugs_in_the_treatment_of_childhood_epilepsy_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0013-9580&date=1999&volume=40&issue=&spage=S29 DB - PRIME DP - Unbound Medicine ER -