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[Accuracy of imaging techniques and tumor markers in the diagnosis of pancreatic cancer].
Gastroenterol Hepatol. 1999 Aug-Sep; 22(7):335-41.GH

Abstract

OBJECTIVE

The aim of this study was to evaluate the diagnostic accuracy of: a) three imaging techniques: ultrasonography (US), computed tomography (CT) and endoscopic retrograde cholangiopancreatography (ERCP), and b) the serum tumor markers CEA, CA 19-9 and CA 125, in the diagnosis of pancreatic cancer.

PATIENTS AND METHODS

A total of 137 patients were prospectively evaluated. Pancreatic cancer was diagnosed in 25 patients; chronic pancreatitis in 24; acute pancreatitis in 22; extrapancreatic malignancies in 24, and benign digestive disease in 42. The reference interval for each marker was determined in 36 healthy volunteers. Diagnostic accuracy was determined using receiver operating characteristic (ROC) curves. Each diagnostic test was used in order: a) to diagnose pancreatic cancer when the disease was clinically suspected, and b) to differentiate between pancreatic cancer and chronic pancreatitis.

RESULTS

CT (0.976-0.888) and US (0.857) diagnostic accuracy resulted greater than the best serum tumor marker CA 19-9 (0.755-0.786) (p = NS), in both diagnostic conditions. To obtain a diagnostic specificity of 90% in pancreatic cancer, the CA 19-9 cutoff level should increase up to 3 and 7.5 folds being in this case better than CEA and CA 125 (p < 0.05).

CONCLUSIONS

CT scan offers the greatest accuracy in the diagnosis of PC. Among the tumor markers, CA 19-9 offers the best accuracy in the diagnosis of pancreatic cancer.

Authors+Show Affiliations

Laboratori d'Investigacio Gastrointestinal, Hospital de la Santa Creu i Sant Pau, Barcelona.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

10535205

Citation

Clavé, P, et al. "[Accuracy of Imaging Techniques and Tumor Markers in the Diagnosis of Pancreatic Cancer]." Gastroenterologia Y Hepatologia, vol. 22, no. 7, 1999, pp. 335-41.
Clavé P, Boadas J, González-Carro P, et al. [Accuracy of imaging techniques and tumor markers in the diagnosis of pancreatic cancer]. Gastroenterol Hepatol. 1999;22(7):335-41.
Clavé, P., Boadas, J., González-Carro, P., Mora, J., Pérez, C., Martínez, A., Roca, M., Lluís, F., & Farré, A. (1999). [Accuracy of imaging techniques and tumor markers in the diagnosis of pancreatic cancer]. Gastroenterologia Y Hepatologia, 22(7), 335-41.
Clavé P, et al. [Accuracy of Imaging Techniques and Tumor Markers in the Diagnosis of Pancreatic Cancer]. Gastroenterol Hepatol. 1999 Aug-Sep;22(7):335-41. PubMed PMID: 10535205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Accuracy of imaging techniques and tumor markers in the diagnosis of pancreatic cancer]. AU - Clavé,P, AU - Boadas,J, AU - González-Carro,P, AU - Mora,J, AU - Pérez,C, AU - Martínez,A, AU - Roca,M, AU - Lluís,F, AU - Farré,A, PY - 1999/10/27/pubmed PY - 2002/2/8/medline PY - 1999/10/27/entrez SP - 335 EP - 41 JF - Gastroenterologia y hepatologia JO - Gastroenterol Hepatol VL - 22 IS - 7 N2 - OBJECTIVE: The aim of this study was to evaluate the diagnostic accuracy of: a) three imaging techniques: ultrasonography (US), computed tomography (CT) and endoscopic retrograde cholangiopancreatography (ERCP), and b) the serum tumor markers CEA, CA 19-9 and CA 125, in the diagnosis of pancreatic cancer. PATIENTS AND METHODS: A total of 137 patients were prospectively evaluated. Pancreatic cancer was diagnosed in 25 patients; chronic pancreatitis in 24; acute pancreatitis in 22; extrapancreatic malignancies in 24, and benign digestive disease in 42. The reference interval for each marker was determined in 36 healthy volunteers. Diagnostic accuracy was determined using receiver operating characteristic (ROC) curves. Each diagnostic test was used in order: a) to diagnose pancreatic cancer when the disease was clinically suspected, and b) to differentiate between pancreatic cancer and chronic pancreatitis. RESULTS: CT (0.976-0.888) and US (0.857) diagnostic accuracy resulted greater than the best serum tumor marker CA 19-9 (0.755-0.786) (p = NS), in both diagnostic conditions. To obtain a diagnostic specificity of 90% in pancreatic cancer, the CA 19-9 cutoff level should increase up to 3 and 7.5 folds being in this case better than CEA and CA 125 (p < 0.05). CONCLUSIONS: CT scan offers the greatest accuracy in the diagnosis of PC. Among the tumor markers, CA 19-9 offers the best accuracy in the diagnosis of pancreatic cancer. SN - 0210-5705 UR - https://www.unboundmedicine.com/medline/citation/10535205/[Accuracy_of_imaging_techniques_and_tumor_markers_in_the_diagnosis_of_pancreatic_cancer]_ L2 - http://www.diseaseinfosearch.org/result/5551 DB - PRIME DP - Unbound Medicine ER -