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Spontaneous or neostigmine-induced recovery after maintenance of neuromuscular block with Org 9487 (rapacuronium) or rocuronium following an initial dose of Org 9487.
Br J Anaesth. 1999 May; 82(5):755-6.BJ

Abstract

We have examined spontaneous and neostigmine-induced recovery after an initial dose of Org 9487 1.5 mg kg-1 followed by three repeat doses of Org 9487, a 30-min infusion of Org 9487 or two incremental doses of rocuronium. Mean clinical duration after incremental doses of Org 9487 0.5 mg kg-1 increased from 12.3 (SD 3.4) min to 14.0 (4.0) and 15.9 (5.9) min (P < 0.01), and after rocuronium from 14.4 (5.2) min to 19.2 (5.9) min (P < 0.01). Times for spontaneous recovery from a T1 of 25% to a TOF ratio of 0.8 after the last bolus dose of Org 9487 and after a 30-min infusion were 72.4 (16.5) and 66.1 (26.9) min compared with 36.7 (15.8) min in the group receiving reocuronium. These times were significantly reduced to 9.9 (4.5), 8.6 (6.1) and 5.7 (2.5) min, respectively, after neostigmine administration at a T1 of 25% (P < 0.05). We conclude that administration of Org 9487 by repeat bolus doses or infusion was associated with slow spontaneous recovery but neostigmine administration resulted in adequate recovery in less than 10 min.

Authors+Show Affiliations

Department of Anaesthetics, Queen's University of Belfast, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10536556

Citation

McCourt, K C., et al. "Spontaneous or Neostigmine-induced Recovery After Maintenance of Neuromuscular Block With Org 9487 (rapacuronium) or Rocuronium Following an Initial Dose of Org 9487." British Journal of Anaesthesia, vol. 82, no. 5, 1999, pp. 755-6.
McCourt KC, Mirakhur RK, Lowry DW, et al. Spontaneous or neostigmine-induced recovery after maintenance of neuromuscular block with Org 9487 (rapacuronium) or rocuronium following an initial dose of Org 9487. Br J Anaesth. 1999;82(5):755-6.
McCourt, K. C., Mirakhur, R. K., Lowry, D. W., Carroll, M. T., & Sparr, H. J. (1999). Spontaneous or neostigmine-induced recovery after maintenance of neuromuscular block with Org 9487 (rapacuronium) or rocuronium following an initial dose of Org 9487. British Journal of Anaesthesia, 82(5), 755-6.
McCourt KC, et al. Spontaneous or Neostigmine-induced Recovery After Maintenance of Neuromuscular Block With Org 9487 (rapacuronium) or Rocuronium Following an Initial Dose of Org 9487. Br J Anaesth. 1999;82(5):755-6. PubMed PMID: 10536556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spontaneous or neostigmine-induced recovery after maintenance of neuromuscular block with Org 9487 (rapacuronium) or rocuronium following an initial dose of Org 9487. AU - McCourt,K C, AU - Mirakhur,R K, AU - Lowry,D W, AU - Carroll,M T, AU - Sparr,H J, PY - 1999/10/28/pubmed PY - 1999/10/28/medline PY - 1999/10/28/entrez SP - 755 EP - 6 JF - British journal of anaesthesia JO - Br J Anaesth VL - 82 IS - 5 N2 - We have examined spontaneous and neostigmine-induced recovery after an initial dose of Org 9487 1.5 mg kg-1 followed by three repeat doses of Org 9487, a 30-min infusion of Org 9487 or two incremental doses of rocuronium. Mean clinical duration after incremental doses of Org 9487 0.5 mg kg-1 increased from 12.3 (SD 3.4) min to 14.0 (4.0) and 15.9 (5.9) min (P < 0.01), and after rocuronium from 14.4 (5.2) min to 19.2 (5.9) min (P < 0.01). Times for spontaneous recovery from a T1 of 25% to a TOF ratio of 0.8 after the last bolus dose of Org 9487 and after a 30-min infusion were 72.4 (16.5) and 66.1 (26.9) min compared with 36.7 (15.8) min in the group receiving reocuronium. These times were significantly reduced to 9.9 (4.5), 8.6 (6.1) and 5.7 (2.5) min, respectively, after neostigmine administration at a T1 of 25% (P < 0.05). We conclude that administration of Org 9487 by repeat bolus doses or infusion was associated with slow spontaneous recovery but neostigmine administration resulted in adequate recovery in less than 10 min. SN - 0007-0912 UR - https://www.unboundmedicine.com/medline/citation/10536556/Spontaneous_or_neostigmine_induced_recovery_after_maintenance_of_neuromuscular_block_with_Org_9487__rapacuronium__or_rocuronium_following_an_initial_dose_of_Org_9487_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0007-0912(17)38535-5 DB - PRIME DP - Unbound Medicine ER -