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The deterioration of cardiovascular reflexes in Parkinson's disease.
Acta Neurol Scand. 1999 Nov; 100(5):296-9.AN

Abstract

OBJECTIVES

We have investigated the deterioration of cardiovascular reflexes in Parkinson's disease.

PATIENTS AND METHODS

In a group of 20 patients with Parkinson's disease (PD) and in a group of 10 age-matched control subjects a battery of cardiovascular reflex (CVR) tests (Valsalva manoeuvre, deep breathing test, handgrip test, orthostatic test) was repeated after 3 years.

RESULTS

In PD patients at deep breathing test, at Valsalva manoeuvre and at orthostatic test the heart rate response decreased significantly (P<0.05). The impairment of systolic and diastolic blood pressure response at orthostatic test was significant as well (P < 0.005). At hand grip test no significant changes in heart rate and blood pressure response were found. In control subjects only heart rate response at orthostatic test decreased significantly after 3 years.

CONCLUSION

Our results show progression of an impairment of sympathetic and parasympathetic control of the cardiovascular functions in patients with PD over a period of 3 years.

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Authors+Show Affiliations

Mesec A
Department of Neurology, University Medical Centre Ljubljana, Slovenia.
Sega S
No affiliation info available
Trost M
No affiliation info available
Pogacnik T
No affiliation info available

MeSH

AgedBlood PressureCardiovascular DiseasesDisease ProgressionFemaleHand StrengthHeart RateHumansMaleMiddle AgedParkinson DiseaseReflex, Abnormal

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10536915

Citation

Mesec, A, et al. "The Deterioration of Cardiovascular Reflexes in Parkinson's Disease." Acta Neurologica Scandinavica, vol. 100, no. 5, 1999, pp. 296-9.
Mesec A, Sega S, Trost M, et al. The deterioration of cardiovascular reflexes in Parkinson's disease. Acta Neurol Scand. 1999;100(5):296-9.
Mesec, A., Sega, S., Trost, M., & Pogacnik, T. (1999). The deterioration of cardiovascular reflexes in Parkinson's disease. Acta Neurologica Scandinavica, 100(5), 296-9.
Mesec A, et al. The Deterioration of Cardiovascular Reflexes in Parkinson's Disease. Acta Neurol Scand. 1999;100(5):296-9. PubMed PMID: 10536915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The deterioration of cardiovascular reflexes in Parkinson's disease. AU - Mesec,A, AU - Sega,S, AU - Trost,M, AU - Pogacnik,T, PY - 1999/10/28/pubmed PY - 1999/10/28/medline PY - 1999/10/28/entrez SP - 296 EP - 9 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 100 IS - 5 N2 - OBJECTIVES: We have investigated the deterioration of cardiovascular reflexes in Parkinson's disease. PATIENTS AND METHODS: In a group of 20 patients with Parkinson's disease (PD) and in a group of 10 age-matched control subjects a battery of cardiovascular reflex (CVR) tests (Valsalva manoeuvre, deep breathing test, handgrip test, orthostatic test) was repeated after 3 years. RESULTS: In PD patients at deep breathing test, at Valsalva manoeuvre and at orthostatic test the heart rate response decreased significantly (P<0.05). The impairment of systolic and diastolic blood pressure response at orthostatic test was significant as well (P < 0.005). At hand grip test no significant changes in heart rate and blood pressure response were found. In control subjects only heart rate response at orthostatic test decreased significantly after 3 years. CONCLUSION: Our results show progression of an impairment of sympathetic and parasympathetic control of the cardiovascular functions in patients with PD over a period of 3 years. SN - 0001-6314 UR - https://www.unboundmedicine.com/medline/citation/10536915/The_deterioration_of_cardiovascular_reflexes_in_Parkinson's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0001-6314&amp;date=1999&amp;volume=100&amp;issue=5&amp;spage=296 DB - PRIME DP - Unbound Medicine ER -