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Extreme elevation of serum transcobalamin I in patients with metastatic cancer.
N Engl J Med. 1975 Feb 06; 292(6):282-4.NEJM

Abstract

Elevation of transcobalamin I and serum vitamin B12 levels has usually been associated with increased granulocytic proliferation, such as occurs in chronic myelogenous leukemia. Two patients with metastatic cancer had extremely high serum vitamin B12 and transcobalamin I levels--greater than those seen in even the most intense granulocytic proliferation--that were not explainable by leukocytosis. The subjects' serum vitamin B12 levels were 18,750 and 21,221 pg per milliliter (normal, 471 plus or minus 174 pg per milliliter, mean plus or minus S.D.) and unsaturated vitamin B12 binding capacity 158,750 and 5,400 pg per milliliter (normal, 1153 plus or minus 313 pg per milliliter) respectively. The abnormally elevated serum binder was shown to be identical with transcobalamin balamin I in every respect. Levels of transcobalamin II and serum third binder were normal. The cause of the binder abnormality is unknown, but factors other than granulocyte proliferation may control or contribute to the production or accumulation of transcobalamin I.

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Publisher Full Text

Authors

Carmel R
No affiliation info available

MeSH

AdenocarcinomaAgedAnimalsBlood ProteinsCarcinomaCarrier ProteinsCell DivisionChromatography, DEAE-CelluloseChromatography, GelCobalt RadioisotopesColonic NeoplasmsFemaleGranulocytesHumansImmune SeraLeukemia, MyeloidLeukocyte CountLiver NeoplasmsLung NeoplasmsMaleMiddle AgedNeoplasm MetastasisNeoplasmsProtein BindingRabbitsRadioligand AssaySalivaStomach NeoplasmsVitamin B 12

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1053806

Citation

Carmel, R. "Extreme Elevation of Serum Transcobalamin I in Patients With Metastatic Cancer." The New England Journal of Medicine, vol. 292, no. 6, 1975, pp. 282-4.
Carmel R. Extreme elevation of serum transcobalamin I in patients with metastatic cancer. N Engl J Med. 1975;292(6):282-4.
Carmel, R. (1975). Extreme elevation of serum transcobalamin I in patients with metastatic cancer. The New England Journal of Medicine, 292(6), 282-4.
Carmel R. Extreme Elevation of Serum Transcobalamin I in Patients With Metastatic Cancer. N Engl J Med. 1975 Feb 6;292(6):282-4. PubMed PMID: 1053806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extreme elevation of serum transcobalamin I in patients with metastatic cancer. A1 - Carmel,R, PY - 1975/2/6/pubmed PY - 1975/2/6/medline PY - 1975/2/6/entrez SP - 282 EP - 4 JF - The New England journal of medicine JO - N Engl J Med VL - 292 IS - 6 N2 - Elevation of transcobalamin I and serum vitamin B12 levels has usually been associated with increased granulocytic proliferation, such as occurs in chronic myelogenous leukemia. Two patients with metastatic cancer had extremely high serum vitamin B12 and transcobalamin I levels--greater than those seen in even the most intense granulocytic proliferation--that were not explainable by leukocytosis. The subjects' serum vitamin B12 levels were 18,750 and 21,221 pg per milliliter (normal, 471 plus or minus 174 pg per milliliter, mean plus or minus S.D.) and unsaturated vitamin B12 binding capacity 158,750 and 5,400 pg per milliliter (normal, 1153 plus or minus 313 pg per milliliter) respectively. The abnormally elevated serum binder was shown to be identical with transcobalamin balamin I in every respect. Levels of transcobalamin II and serum third binder were normal. The cause of the binder abnormality is unknown, but factors other than granulocyte proliferation may control or contribute to the production or accumulation of transcobalamin I. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/1053806/Extreme_elevation_of_serum_transcobalamin_I_in_patients_with_metastatic_cancer_ L2 - https://www.nejm.org/doi/10.1056/NEJM197502062920603?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -