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An estimation of selenium requirements for New Zealanders.
Am J Clin Nutr 1999; 70(5):896-903AJ

Abstract

BACKGROUND

Current US dietary recommendations for selenium are based on maximization of plasma glutathione peroxidase (GSHPx) activity according to data from one study of Chinese men.

OBJECTIVE

The effect of various amounts of supplemental selenium on GSHPx activities in blood of New Zealand adults was investigated to calculate a selenium requirement for New Zealanders. The effect on plasma selenoprotein P and thyroid hormones was also investigated.

DESIGN

Fifty-two adults with low blood selenium concentrations ingested a placebo or 10, 20, 30, or 40 microgram Se as L-selenomethionine daily for 20 wk.

RESULTS

Plasma and whole-blood GSHPx activities increased in all supplemented groups but reached a plateau only in the group receiving 40 microgram Se, as determined by statistical analysis. Increases in selenoprotein P were greater than those for selenium and GSHPx at all supplement intakes. Thyroxine concentrations decreased in supplemented groups but the decrease was significantly different from that in the control group only for the 10-microgram group and for all supplemented groups combined.

CONCLUSIONS

An upper estimated requirement of 90 microgram Se/d was calculated as the intake necessary for maximization of plasma GSHPx activity, as used in the derivation of the US recommended daily allowance. Our lower estimated requirement of 39 microgram Se/d was the intake necessary to reach two-thirds of maximal GSHPx activity, as was used in calculating the World Health Organization normative requirement. The lower estimate is a realistic goal for New Zealand but the upper estimate could be achieved only with regular inclusion of high-selenium foods.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Duffield AJ
    Department of Human Nutrition, University of Otago, Dunedin, New Zealand.
    Thomson CD
    No affiliation info available
    Hill KE
    No affiliation info available
    Williams S
    No affiliation info available

    MeSH

    AdultDouble-Blind MethodFemaleGlutathione PeroxidaseHumansMaleMiddle AgedNew ZealandNutrition PolicyNutritional RequirementsProteinsRadioimmunoassaySeleniumSelenoprotein PSelenoproteinsThyroxine

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10539752

    Citation

    Duffield, A J., et al. "An Estimation of Selenium Requirements for New Zealanders." The American Journal of Clinical Nutrition, vol. 70, no. 5, 1999, pp. 896-903.
    Duffield AJ, Thomson CD, Hill KE, et al. An estimation of selenium requirements for New Zealanders. Am J Clin Nutr. 1999;70(5):896-903.
    Duffield, A. J., Thomson, C. D., Hill, K. E., & Williams, S. (1999). An estimation of selenium requirements for New Zealanders. The American Journal of Clinical Nutrition, 70(5), pp. 896-903.
    Duffield AJ, et al. An Estimation of Selenium Requirements for New Zealanders. Am J Clin Nutr. 1999;70(5):896-903. PubMed PMID: 10539752.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - An estimation of selenium requirements for New Zealanders. AU - Duffield,A J, AU - Thomson,C D, AU - Hill,K E, AU - Williams,S, PY - 1999/10/28/pubmed PY - 1999/10/28/medline PY - 1999/10/28/entrez SP - 896 EP - 903 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 70 IS - 5 N2 - BACKGROUND: Current US dietary recommendations for selenium are based on maximization of plasma glutathione peroxidase (GSHPx) activity according to data from one study of Chinese men. OBJECTIVE: The effect of various amounts of supplemental selenium on GSHPx activities in blood of New Zealand adults was investigated to calculate a selenium requirement for New Zealanders. The effect on plasma selenoprotein P and thyroid hormones was also investigated. DESIGN: Fifty-two adults with low blood selenium concentrations ingested a placebo or 10, 20, 30, or 40 microgram Se as L-selenomethionine daily for 20 wk. RESULTS: Plasma and whole-blood GSHPx activities increased in all supplemented groups but reached a plateau only in the group receiving 40 microgram Se, as determined by statistical analysis. Increases in selenoprotein P were greater than those for selenium and GSHPx at all supplement intakes. Thyroxine concentrations decreased in supplemented groups but the decrease was significantly different from that in the control group only for the 10-microgram group and for all supplemented groups combined. CONCLUSIONS: An upper estimated requirement of 90 microgram Se/d was calculated as the intake necessary for maximization of plasma GSHPx activity, as used in the derivation of the US recommended daily allowance. Our lower estimated requirement of 39 microgram Se/d was the intake necessary to reach two-thirds of maximal GSHPx activity, as was used in calculating the World Health Organization normative requirement. The lower estimate is a realistic goal for New Zealand but the upper estimate could be achieved only with regular inclusion of high-selenium foods. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/10539752/An_estimation_of_selenium_requirements_for_New_Zealanders_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/70.5.896 DB - PRIME DP - Unbound Medicine ER -