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[Regulation of gene expression and vitamin].
Nihon Rinsho. 1999 Oct; 57(10):2295-300.NR

Abstract

Action of 1,25-dihydroxyvitamin D, the most active metabolite of vitamin D, is exerted by the nuclear vitamin D receptor (VDR) mediated gene expression. Toward the expression of vitamin D function, several steps including 1,25-dihydroxyvitamin D production, tissue specific expression of VDR and transcription of target gene by VDR are involved. One of the important progress in vitamin D metabolism is the cloning of 25-hydroxyvitamin D-24-hydroxylase gene and 1 alpha-hydroxylase gene. Structural organization of the human VDR chromosomal gene and its promoter was also important to understand the amount of VDR expressed in tissues. A part of mechanism of tissue specific expression of VDR have recently been reported. Furthermore, VDR recruit several coactivators to achieve vitamin D-induced transactivation. Selective coactivator interaction with VDR may specify the array of biological actions of vitamin D.

Authors+Show Affiliations

Department of Clinical Nutrition, School of Medicine, University of Tokushima.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

10540876

Citation

Takeda, E, et al. "[Regulation of Gene Expression and Vitamin]." Nihon Rinsho. Japanese Journal of Clinical Medicine, vol. 57, no. 10, 1999, pp. 2295-300.
Takeda E, Yamamoto H, Miyamoto K. [Regulation of gene expression and vitamin]. Nippon Rinsho. 1999;57(10):2295-300.
Takeda, E., Yamamoto, H., & Miyamoto, K. (1999). [Regulation of gene expression and vitamin]. Nihon Rinsho. Japanese Journal of Clinical Medicine, 57(10), 2295-300.
Takeda E, Yamamoto H, Miyamoto K. [Regulation of Gene Expression and Vitamin]. Nippon Rinsho. 1999;57(10):2295-300. PubMed PMID: 10540876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Regulation of gene expression and vitamin]. AU - Takeda,E, AU - Yamamoto,H, AU - Miyamoto,K, PY - 1999/12/14/pubmed PY - 1999/12/14/medline PY - 1999/12/14/entrez SP - 2295 EP - 300 JF - Nihon rinsho. Japanese journal of clinical medicine JO - Nippon Rinsho VL - 57 IS - 10 N2 - Action of 1,25-dihydroxyvitamin D, the most active metabolite of vitamin D, is exerted by the nuclear vitamin D receptor (VDR) mediated gene expression. Toward the expression of vitamin D function, several steps including 1,25-dihydroxyvitamin D production, tissue specific expression of VDR and transcription of target gene by VDR are involved. One of the important progress in vitamin D metabolism is the cloning of 25-hydroxyvitamin D-24-hydroxylase gene and 1 alpha-hydroxylase gene. Structural organization of the human VDR chromosomal gene and its promoter was also important to understand the amount of VDR expressed in tissues. A part of mechanism of tissue specific expression of VDR have recently been reported. Furthermore, VDR recruit several coactivators to achieve vitamin D-induced transactivation. Selective coactivator interaction with VDR may specify the array of biological actions of vitamin D. SN - 0047-1852 UR - https://www.unboundmedicine.com/medline/citation/10540876/[Regulation_of_gene_expression_and_vitamin]_ L2 - https://medlineplus.gov/vitamind.html DB - PRIME DP - Unbound Medicine ER -
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