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Intestinal hyperabsorption of oxalate in calcium oxalate stone formers: application of a new test with [13C2]oxalate.
J Am Soc Nephrol. 1999 Nov; 10 Suppl 14:S329-33.JA

Abstract

In up to one-third of patients with calcium oxalate stones, a hyperoxaluria can be detected. Hyperoxaluria can result from increased endogenous production, from excessive oxalate content of the food, or from intestinal hyperabsorption. For a causal therapy, it is important to discriminate between metabolic and hyperabsorptive hyperoxaluria. Our new 13C-oxalate test allows this differentiation. Under standardized conditions, 50 mg of disodium salt of [13C2]oxalic acid was applied. From the amount of labeled oxalate excreted in urine as measured by a gas chromatographic-mass spectrometric assay, the intestinal absorption was calculated. Seventy patients with recurrent calcium oxalate urolithiasis who had no signs of inflammatory bowel disease were tested. Their mean intestinal oxalate absorption was 9.2+/-5.1%. This was significantly higher than the mean absorption of 50 healthy volunteers (6.7+/-3.9%). There was no difference in oxalate absorption between male (n = 25) and female volunteers. Oxalate absorption correlated with the oxalate excretion in the 24-h urine (volunteers: r = 0.46, P < 0.01; patients: r = 0.62, P < 0.001). Oxalate hyperabsorption was defined as an absorption exceeding 10%. According to this definition, 34% of the patients had oxalate hyperabsorption; 20% of the volunteers showed a hyperabsorption, too. The 13C-oxalate absorption test allows reliable determination of intestinal oxalate absorption. Because of the use of a stable isotope, this test may be repeated as often as required. It will allow the control of therapeutic regimens and also help to unravel genetic influences in stone formation.

Authors+Show Affiliations

Department of Urology, University of Bonn, Germany. hesse@uni-bonn.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10541257

Citation

Hesse, A, et al. "Intestinal Hyperabsorption of Oxalate in Calcium Oxalate Stone Formers: Application of a New Test With [13C2]oxalate." Journal of the American Society of Nephrology : JASN, vol. 10 Suppl 14, 1999, pp. S329-33.
Hesse A, Schneeberger W, Engfeld S, et al. Intestinal hyperabsorption of oxalate in calcium oxalate stone formers: application of a new test with [13C2]oxalate. J Am Soc Nephrol. 1999;10 Suppl 14:S329-33.
Hesse, A., Schneeberger, W., Engfeld, S., Von Unruh, G. E., & Sauerbruch, T. (1999). Intestinal hyperabsorption of oxalate in calcium oxalate stone formers: application of a new test with [13C2]oxalate. Journal of the American Society of Nephrology : JASN, 10 Suppl 14, S329-33.
Hesse A, et al. Intestinal Hyperabsorption of Oxalate in Calcium Oxalate Stone Formers: Application of a New Test With [13C2]oxalate. J Am Soc Nephrol. 1999;10 Suppl 14:S329-33. PubMed PMID: 10541257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal hyperabsorption of oxalate in calcium oxalate stone formers: application of a new test with [13C2]oxalate. AU - Hesse,A, AU - Schneeberger,W, AU - Engfeld,S, AU - Von Unruh,G E, AU - Sauerbruch,T, PY - 1999/11/30/pubmed PY - 1999/11/30/medline PY - 1999/11/30/entrez SP - S329 EP - 33 JF - Journal of the American Society of Nephrology : JASN JO - J. Am. Soc. Nephrol. VL - 10 Suppl 14 N2 - In up to one-third of patients with calcium oxalate stones, a hyperoxaluria can be detected. Hyperoxaluria can result from increased endogenous production, from excessive oxalate content of the food, or from intestinal hyperabsorption. For a causal therapy, it is important to discriminate between metabolic and hyperabsorptive hyperoxaluria. Our new 13C-oxalate test allows this differentiation. Under standardized conditions, 50 mg of disodium salt of [13C2]oxalic acid was applied. From the amount of labeled oxalate excreted in urine as measured by a gas chromatographic-mass spectrometric assay, the intestinal absorption was calculated. Seventy patients with recurrent calcium oxalate urolithiasis who had no signs of inflammatory bowel disease were tested. Their mean intestinal oxalate absorption was 9.2+/-5.1%. This was significantly higher than the mean absorption of 50 healthy volunteers (6.7+/-3.9%). There was no difference in oxalate absorption between male (n = 25) and female volunteers. Oxalate absorption correlated with the oxalate excretion in the 24-h urine (volunteers: r = 0.46, P < 0.01; patients: r = 0.62, P < 0.001). Oxalate hyperabsorption was defined as an absorption exceeding 10%. According to this definition, 34% of the patients had oxalate hyperabsorption; 20% of the volunteers showed a hyperabsorption, too. The 13C-oxalate absorption test allows reliable determination of intestinal oxalate absorption. Because of the use of a stable isotope, this test may be repeated as often as required. It will allow the control of therapeutic regimens and also help to unravel genetic influences in stone formation. SN - 1046-6673 UR - https://www.unboundmedicine.com/medline/citation/10541257/Intestinal_hyperabsorption_of_oxalate_in_calcium_oxalate_stone_formers:_application_of_a_new_test_with_[13C2]oxalate_ DB - PRIME DP - Unbound Medicine ER -