Tags

Type your tag names separated by a space and hit enter

Effects of microgravity on urinary osteopontin.
J Am Soc Nephrol. 1999 Nov; 10 Suppl 14:S389-93.JA

Abstract

Increased risk of renal stone formation during space flight has been linked primarily to increased calcium excretion from bone demineralization induced by space flight. Other factors contributing to increased risk include increased urinary calcium oxalate supersaturation, while urinary citrate, magnesium and volume are all decreased. The aim of this study was to increase the predictive value of stone risk profiles for crew members during space flight by evaluating the excretion of urinary protein inhibitors of calcium crystallization so that more comprehensive stone risk profiles could relate mineral saturation to the concentrations of inhibitor proteins. Levels of urinary osteopontin (uropontin) are reported in a series of 14 astronauts studied before, during, and after space flights. During space flight, a compensatory increase in uropontin excretion was not observed. However, the uropontin excretion of a majority of astronauts was increased during the period after space flight and was maximal at 2 wk after landing. The downward shift in the molecular size of uropontin observed in samples obtained during space flight was shown to result from storage at ambient temperature during flight, rather than an effect of microgravity on uropontin synthesis.

Authors+Show Affiliations

Department of Pediatrics, University of Pennsylvania and Children's Hospital of Philadelphia, 19104-4318, USA. hoyer@email.chop.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10541270

Citation

Hoyer, J R., et al. "Effects of Microgravity On Urinary Osteopontin." Journal of the American Society of Nephrology : JASN, vol. 10 Suppl 14, 1999, pp. S389-93.
Hoyer JR, Pietrzyk RA, Liu H, et al. Effects of microgravity on urinary osteopontin. J Am Soc Nephrol. 1999;10 Suppl 14:S389-93.
Hoyer, J. R., Pietrzyk, R. A., Liu, H., & Whitson, P. A. (1999). Effects of microgravity on urinary osteopontin. Journal of the American Society of Nephrology : JASN, 10 Suppl 14, S389-93.
Hoyer JR, et al. Effects of Microgravity On Urinary Osteopontin. J Am Soc Nephrol. 1999;10 Suppl 14:S389-93. PubMed PMID: 10541270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of microgravity on urinary osteopontin. AU - Hoyer,J R, AU - Pietrzyk,R A, AU - Liu,H, AU - Whitson,P A, PY - 1999/11/30/pubmed PY - 1999/11/30/medline PY - 1999/11/30/entrez KW - NASA Center JSC KW - NASA Discipline Regulatory Physiology KW - NASA Experiment Number 9401651 KW - NASA Program Biomedical Research and Countermeasures SP - S389 EP - 93 JF - Journal of the American Society of Nephrology : JASN JO - J Am Soc Nephrol VL - 10 Suppl 14 N2 - Increased risk of renal stone formation during space flight has been linked primarily to increased calcium excretion from bone demineralization induced by space flight. Other factors contributing to increased risk include increased urinary calcium oxalate supersaturation, while urinary citrate, magnesium and volume are all decreased. The aim of this study was to increase the predictive value of stone risk profiles for crew members during space flight by evaluating the excretion of urinary protein inhibitors of calcium crystallization so that more comprehensive stone risk profiles could relate mineral saturation to the concentrations of inhibitor proteins. Levels of urinary osteopontin (uropontin) are reported in a series of 14 astronauts studied before, during, and after space flights. During space flight, a compensatory increase in uropontin excretion was not observed. However, the uropontin excretion of a majority of astronauts was increased during the period after space flight and was maximal at 2 wk after landing. The downward shift in the molecular size of uropontin observed in samples obtained during space flight was shown to result from storage at ambient temperature during flight, rather than an effect of microgravity on uropontin synthesis. SN - 1046-6673 UR - https://www.unboundmedicine.com/medline/citation/10541270/Effects_of_microgravity_on_urinary_osteopontin_ L2 - https://antibodies.cancer.gov/detail/CPTC-SPP1-1 DB - PRIME DP - Unbound Medicine ER -