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HLA-B27 subtypes in patients with ankylosing spondylitis (As) in Colombia.
Rev Invest Clin. 1999 Jul-Aug; 51(4):221-6.RI

Abstract

OBJECTIVE

We investigated the distribution of HLA-B27 subtypes in patients with ankylosing spondylitis (AS) belonging to two ethnic groups of Colombia.

MATERIAL AND METHODS

PCR-SSOs was used to detect the polymorphism in exons 2 and 3 of HLA-B27 in two groups of patients: 39 Mulattos and 20 Mestizos. Fifty-nine of them suffered of ankylosing spondylitis (AS), including two patients with ankylosing spondylitis plus anterior uveitis (AU). Only two out of eight HLA-B27 subtypes studied (B*2701-B*2708) were found.

RESULTS

The distribution of these alleles in the whole population was: B*2705: 87.1% and B*2702: 12.8% in the Mulattos group; 80% were B*2705 and 20% B*2702 in Mestizos group. The distribution of HLA-B27 subtypes was: 84.74% of patients with AS were B*2705 and 15.26% B*2702.

CONCLUSIONS

There was no significant difference in the distribution of HLA-B27 subtypes among the patients ethnic groups studied. Other authors have shown that B*2705, B*2702 and B*2704, the more frequent subtypes, are equally associated to the disease. Although population studies need to be done to analyze the distribution of subtypes between patients and controls, the low frequency of HLA-B27 within the normal population does not permit to do a representative number of controls; our results suggest that HLA-B*2705 and HLA-B*2702 are the subtypes more frequently associated with AS in patients from the two more prevalent patients ethnic groups in Colombia.

Authors+Show Affiliations

Instituto de Investigaciones Inmunológicas, Universidad de Cartagena, Colombia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

10546503

Citation

Martínez, B, et al. "HLA-B27 Subtypes in Patients With Ankylosing Spondylitis (As) in Colombia." Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, vol. 51, no. 4, 1999, pp. 221-6.
Martínez B, Caraballo L, Hernández M, et al. HLA-B27 subtypes in patients with ankylosing spondylitis (As) in Colombia. Rev Invest Clin. 1999;51(4):221-6.
Martínez, B., Caraballo, L., Hernández, M., Valle, R., Avila, M., & Iglesias Gamarra, A. (1999). HLA-B27 subtypes in patients with ankylosing spondylitis (As) in Colombia. Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, 51(4), 221-6.
Martínez B, et al. HLA-B27 Subtypes in Patients With Ankylosing Spondylitis (As) in Colombia. Rev Invest Clin. 1999 Jul-Aug;51(4):221-6. PubMed PMID: 10546503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-B27 subtypes in patients with ankylosing spondylitis (As) in Colombia. AU - Martínez,B, AU - Caraballo,L, AU - Hernández,M, AU - Valle,R, AU - Avila,M, AU - Iglesias Gamarra,A, PY - 1999/11/5/pubmed PY - 1999/11/5/medline PY - 1999/11/5/entrez SP - 221 EP - 6 JF - Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion JO - Rev Invest Clin VL - 51 IS - 4 N2 - OBJECTIVE: We investigated the distribution of HLA-B27 subtypes in patients with ankylosing spondylitis (AS) belonging to two ethnic groups of Colombia. MATERIAL AND METHODS: PCR-SSOs was used to detect the polymorphism in exons 2 and 3 of HLA-B27 in two groups of patients: 39 Mulattos and 20 Mestizos. Fifty-nine of them suffered of ankylosing spondylitis (AS), including two patients with ankylosing spondylitis plus anterior uveitis (AU). Only two out of eight HLA-B27 subtypes studied (B*2701-B*2708) were found. RESULTS: The distribution of these alleles in the whole population was: B*2705: 87.1% and B*2702: 12.8% in the Mulattos group; 80% were B*2705 and 20% B*2702 in Mestizos group. The distribution of HLA-B27 subtypes was: 84.74% of patients with AS were B*2705 and 15.26% B*2702. CONCLUSIONS: There was no significant difference in the distribution of HLA-B27 subtypes among the patients ethnic groups studied. Other authors have shown that B*2705, B*2702 and B*2704, the more frequent subtypes, are equally associated to the disease. Although population studies need to be done to analyze the distribution of subtypes between patients and controls, the low frequency of HLA-B27 within the normal population does not permit to do a representative number of controls; our results suggest that HLA-B*2705 and HLA-B*2702 are the subtypes more frequently associated with AS in patients from the two more prevalent patients ethnic groups in Colombia. SN - 0034-8376 UR - https://www.unboundmedicine.com/medline/citation/10546503/HLA_B27_subtypes_in_patients_with_ankylosing_spondylitis__As__in_Colombia_ DB - PRIME DP - Unbound Medicine ER -