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Race and clinical outcome in endometrial carcinoma.

Abstract

OBJECTIVE

To compare the outcomes of black and white women who have surgically staged endometrial carcinoma.

METHODS

We retrospectively compared the clinicopathologic factors, socioeconomic status, treatments, and outcomes of 70 black and 302 white women who were treated for surgically staged endometrial carcinoma at our institution.

RESULTS

Black women had higher-grade tumors, less favorable histologic findings, more comorbid illnesses, and lower socioeconomic indices. A nonsignificant trend was also seen toward more advanced-stage disease. The extent of surgical staging and types of adjuvant therapies were similar. On univariate analysis, black women had worse 5-year disease-free survival than white women (52.8% versus 75.2%; P = .001). Other significant factors included stage, grade, lymph node status, extension to the uterine serosa, cervical involvement, histology, adnexal involvement, lymphovascular invasion, myometrial invasion, positive peritoneal cytology, level of education, and household income. After controlling for pathologic and socioeconomic differences in multivariate analysis, race remained a significant prognostic factor (P = .008; hazard rate 2.0; 95% confidence interval 1.2, 3.5).

CONCLUSION

In a large cohort of surgically staged and uniformly treated patients with endometrial carcinoma, black race was associated with significantly worse outcomes, even after controlling for clinicopathologic and socioeconomic factors.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Radiation and Cellular Oncology, University of Chicago Hospitals, Illinois 60637, USA.

    , ,

    Source

    Obstetrics and gynecology 94:5 Pt 1 1999 Nov pg 713-20

    MeSH

    African Americans
    Aged
    Endometrial Neoplasms
    European Continental Ancestry Group
    Female
    Follow-Up Studies
    Humans
    Middle Aged
    Prognosis
    Retrospective Studies
    Socioeconomic Factors

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    10546716

    Citation

    Connell, P P., et al. "Race and Clinical Outcome in Endometrial Carcinoma." Obstetrics and Gynecology, vol. 94, no. 5 Pt 1, 1999, pp. 713-20.
    Connell PP, Rotmensch J, Waggoner SE, et al. Race and clinical outcome in endometrial carcinoma. Obstet Gynecol. 1999;94(5 Pt 1):713-20.
    Connell, P. P., Rotmensch, J., Waggoner, S. E., & Mundt, A. J. (1999). Race and clinical outcome in endometrial carcinoma. Obstetrics and Gynecology, 94(5 Pt 1), pp. 713-20.
    Connell PP, et al. Race and Clinical Outcome in Endometrial Carcinoma. Obstet Gynecol. 1999;94(5 Pt 1):713-20. PubMed PMID: 10546716.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Race and clinical outcome in endometrial carcinoma. AU - Connell,P P, AU - Rotmensch,J, AU - Waggoner,S E, AU - Mundt,A J, PY - 1999/11/5/pubmed PY - 1999/11/5/medline PY - 1999/11/5/entrez SP - 713 EP - 20 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 94 IS - 5 Pt 1 N2 - OBJECTIVE: To compare the outcomes of black and white women who have surgically staged endometrial carcinoma. METHODS: We retrospectively compared the clinicopathologic factors, socioeconomic status, treatments, and outcomes of 70 black and 302 white women who were treated for surgically staged endometrial carcinoma at our institution. RESULTS: Black women had higher-grade tumors, less favorable histologic findings, more comorbid illnesses, and lower socioeconomic indices. A nonsignificant trend was also seen toward more advanced-stage disease. The extent of surgical staging and types of adjuvant therapies were similar. On univariate analysis, black women had worse 5-year disease-free survival than white women (52.8% versus 75.2%; P = .001). Other significant factors included stage, grade, lymph node status, extension to the uterine serosa, cervical involvement, histology, adnexal involvement, lymphovascular invasion, myometrial invasion, positive peritoneal cytology, level of education, and household income. After controlling for pathologic and socioeconomic differences in multivariate analysis, race remained a significant prognostic factor (P = .008; hazard rate 2.0; 95% confidence interval 1.2, 3.5). CONCLUSION: In a large cohort of surgically staged and uniformly treated patients with endometrial carcinoma, black race was associated with significantly worse outcomes, even after controlling for clinicopathologic and socioeconomic factors. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/10546716/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0029784499003816 DB - PRIME DP - Unbound Medicine ER -