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Recent heavy drinking of alcohol and embolic stroke.

Abstract

BACKGROUND AND PURPOSE

Epidemiological evidence suggests that heavy alcohol consumption increases the risk for ischemic stroke, whereas light-to-moderate alcohol intake decreases the risk, but the role of different drinking patterns has remained unclear. We investigated recent light, moderate, and heavy alcohol drinking and former heavy drinking as risk factors for acute ischemic brain infarction by etiological subtype of stroke.

METHODS

We compared 212 consecutive patients aged between 16 and 60 years, who were completely evaluated for the etiology of their ischemic stroke, with 274 control subjects admitted to the emergency unit of the same hospital. ORs, as estimates of multivariate relative risks (RRs), and 95% CIs after adjustment for possible confounding variables were calculated by logistic regression. The ORs were adjusted for age, sex, body mass index, hypertension, diabetes, hyperlipemia, current smoking, and history of migraine.

RESULTS

Recent heavy drinking but not former heavy drinking was an independent risk factor for stroke (RR 1.82, 95% CI 1.08 to 3.05). Consumption of 151 to 300 g and >300 g alcohol within the week preceding the onset of stroke significantly increased the risk for cardioembolic and cryptogenic stroke. Consumption of >40 g alcohol within the preceding 24 hours increased the risk for cardiogenic embolism to the brain among those who had a high-risk source (RR 4.75, 95% CI 1.23 to 18.4), the risk for tandem embolism among those who had prominent large-artery atherosclerosis (RR 7.68, 95% CI 1.82 to 32.3), and the risk for cryptogenic stroke (RR 3.84, 95% CI 1.69 to 8.71). Light drinking did not increase the risk for stroke.

CONCLUSIONS

We conclude that acute drinking of intoxicating amounts of alcohol may trigger the onset of embolic stroke among subjects who have a source of thrombus in the heart or the large arteries.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Oulu University Central Hospital, Finland. matti.hillbom@oulu.fi

    ,

    Source

    Stroke 30:11 1999 Nov pg 2307-12

    MeSH

    Adolescent
    Adult
    Age Factors
    Alcohol Drinking
    Alcoholic Intoxication
    Body Mass Index
    Case-Control Studies
    Cerebral Infarction
    Confidence Intervals
    Confounding Factors (Epidemiology)
    Diabetes Complications
    Ethanol
    Female
    Humans
    Hyperlipidemias
    Hypertension
    Intracranial Embolism
    Logistic Models
    Male
    Middle Aged
    Migraine Disorders
    Multivariate Analysis
    Odds Ratio
    Risk Factors
    Sex Factors
    Smoking
    Stroke

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10548663

    Citation

    Hillbom, M, et al. "Recent Heavy Drinking of Alcohol and Embolic Stroke." Stroke, vol. 30, no. 11, 1999, pp. 2307-12.
    Hillbom M, Numminen H, Juvela S. Recent heavy drinking of alcohol and embolic stroke. Stroke. 1999;30(11):2307-12.
    Hillbom, M., Numminen, H., & Juvela, S. (1999). Recent heavy drinking of alcohol and embolic stroke. Stroke, 30(11), pp. 2307-12.
    Hillbom M, Numminen H, Juvela S. Recent Heavy Drinking of Alcohol and Embolic Stroke. Stroke. 1999;30(11):2307-12. PubMed PMID: 10548663.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Recent heavy drinking of alcohol and embolic stroke. AU - Hillbom,M, AU - Numminen,H, AU - Juvela,S, PY - 1999/11/5/pubmed PY - 1999/11/5/medline PY - 1999/11/5/entrez SP - 2307 EP - 12 JF - Stroke JO - Stroke VL - 30 IS - 11 N2 - BACKGROUND AND PURPOSE: Epidemiological evidence suggests that heavy alcohol consumption increases the risk for ischemic stroke, whereas light-to-moderate alcohol intake decreases the risk, but the role of different drinking patterns has remained unclear. We investigated recent light, moderate, and heavy alcohol drinking and former heavy drinking as risk factors for acute ischemic brain infarction by etiological subtype of stroke. METHODS: We compared 212 consecutive patients aged between 16 and 60 years, who were completely evaluated for the etiology of their ischemic stroke, with 274 control subjects admitted to the emergency unit of the same hospital. ORs, as estimates of multivariate relative risks (RRs), and 95% CIs after adjustment for possible confounding variables were calculated by logistic regression. The ORs were adjusted for age, sex, body mass index, hypertension, diabetes, hyperlipemia, current smoking, and history of migraine. RESULTS: Recent heavy drinking but not former heavy drinking was an independent risk factor for stroke (RR 1.82, 95% CI 1.08 to 3.05). Consumption of 151 to 300 g and >300 g alcohol within the week preceding the onset of stroke significantly increased the risk for cardioembolic and cryptogenic stroke. Consumption of >40 g alcohol within the preceding 24 hours increased the risk for cardiogenic embolism to the brain among those who had a high-risk source (RR 4.75, 95% CI 1.23 to 18.4), the risk for tandem embolism among those who had prominent large-artery atherosclerosis (RR 7.68, 95% CI 1.82 to 32.3), and the risk for cryptogenic stroke (RR 3.84, 95% CI 1.69 to 8.71). Light drinking did not increase the risk for stroke. CONCLUSIONS: We conclude that acute drinking of intoxicating amounts of alcohol may trigger the onset of embolic stroke among subjects who have a source of thrombus in the heart or the large arteries. SN - 0039-2499 UR - https://www.unboundmedicine.com/medline/citation/10548663/Recent_heavy_drinking_of_alcohol_and_embolic_stroke_ L2 - http://Insights.ovid.com/pubmed?pmid=10548663 DB - PRIME DP - Unbound Medicine ER -