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Enantioresolution of pharmaceutical compounds by capillary electrophoresis. Use of cyclodextrins and antibiotics.
Enantiomer. 1999; 4(3-4):229-41.E

Abstract

Capillary electrophoresis (CE) is a powerful tool for the analysis of chiral compounds of pharmaceutical interest. The separation of enantiomers can be achieved using a chiral environment responsible for the diastereoisomers formation (stable or labile in the indirect or direct separation method, respectively). A wide number of chiral selectors have been employed in CE and among them cyclodextrins or their derivatives and antibiotics are the most used stereoselective agents. The review surveys the chiral separation of drugs using the above mentioned chiral selectors by CE. The main parameters influencing the enantioresolution, e.g., chiral selector type and concentration, buffer type, concentration, pH, organic modifier as well as the capillary temperature are discussed. Finally some selected applications to real samples such as pharmaceutical formulations, serum, urine are also discussed.

Authors+Show Affiliations

Fanali S
Istituto di Cromatografia del C.N.R., Monterolondo Scalo, Roma, Italy. fanali@nser.icmat.mlib.cnr.it
Aturki Z
No affiliation info available
Desiderio C
No affiliation info available

MeSH

Anti-Bacterial AgentsCyclodextrinsElectrophoresis, CapillaryMolecular StructurePharmaceutical PreparationsStereoisomerismVancomycin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10550888

Citation

Fanali, S, et al. "Enantioresolution of Pharmaceutical Compounds By Capillary Electrophoresis. Use of Cyclodextrins and Antibiotics." Enantiomer, vol. 4, no. 3-4, 1999, pp. 229-41.
Fanali S, Aturki Z, Desiderio C. Enantioresolution of pharmaceutical compounds by capillary electrophoresis. Use of cyclodextrins and antibiotics. Enantiomer. 1999;4(3-4):229-41.
Fanali, S., Aturki, Z., & Desiderio, C. (1999). Enantioresolution of pharmaceutical compounds by capillary electrophoresis. Use of cyclodextrins and antibiotics. Enantiomer, 4(3-4), 229-41.
Fanali S, Aturki Z, Desiderio C. Enantioresolution of Pharmaceutical Compounds By Capillary Electrophoresis. Use of Cyclodextrins and Antibiotics. Enantiomer. 1999;4(3-4):229-41. PubMed PMID: 10550888.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enantioresolution of pharmaceutical compounds by capillary electrophoresis. Use of cyclodextrins and antibiotics. AU - Fanali,S, AU - Aturki,Z, AU - Desiderio,C, PY - 1999/11/7/pubmed PY - 1999/11/7/medline PY - 1999/11/7/entrez SP - 229 EP - 41 JF - Enantiomer JO - Enantiomer VL - 4 IS - 3-4 N2 - Capillary electrophoresis (CE) is a powerful tool for the analysis of chiral compounds of pharmaceutical interest. The separation of enantiomers can be achieved using a chiral environment responsible for the diastereoisomers formation (stable or labile in the indirect or direct separation method, respectively). A wide number of chiral selectors have been employed in CE and among them cyclodextrins or their derivatives and antibiotics are the most used stereoselective agents. The review surveys the chiral separation of drugs using the above mentioned chiral selectors by CE. The main parameters influencing the enantioresolution, e.g., chiral selector type and concentration, buffer type, concentration, pH, organic modifier as well as the capillary temperature are discussed. Finally some selected applications to real samples such as pharmaceutical formulations, serum, urine are also discussed. SN - 1024-2430 UR - https://www.unboundmedicine.com/medline/citation/10550888/Enantioresolution_of_pharmaceutical_compounds_by_capillary_electrophoresis__Use_of_cyclodextrins_and_antibiotics_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -