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Acute myocardial infarction following sildenafil citrate (Viagra) intake in a nitrate-free patient.
Clin Cardiol. 1999 Nov; 22(11):762-3.CC

Abstract

Since its introduction to the market in March 1997, sildenafil acetate (Viagra) has been prescribed to 1.7 million people. Sixteen men who were taking the drug have died, 7 of them during or soon after sexual activity. Most of these data have been derived from the media and not from the scientific literature. There is a general impression that cardiovascular complications of sildenafil occur mainly when the drug is taken concomitantly with nitrates. We describe a 65-year-old man with known coronary artery disease who had an acute myocardial infarction shortly after taking sildenafil and engaging an sexual activity. The patient had not been using nitrates. We suggest that the emotional arousal induced by Viagra, followed by the heavy physical exertion during sexual activity, triggers plaque rupture that leads to acute myocardial infarction.

Authors+Show Affiliations

Department of Cardiology, Rabin Medical Center, Petah Tiqva, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10554698

Citation

Porter, A, et al. "Acute Myocardial Infarction Following Sildenafil Citrate (Viagra) Intake in a Nitrate-free Patient." Clinical Cardiology, vol. 22, no. 11, 1999, pp. 762-3.
Porter A, Mager A, Birnbaum Y, et al. Acute myocardial infarction following sildenafil citrate (Viagra) intake in a nitrate-free patient. Clin Cardiol. 1999;22(11):762-3.
Porter, A., Mager, A., Birnbaum, Y., Strasberg, B., Sclarovsky, S., & Rechavia, E. (1999). Acute myocardial infarction following sildenafil citrate (Viagra) intake in a nitrate-free patient. Clinical Cardiology, 22(11), 762-3.
Porter A, et al. Acute Myocardial Infarction Following Sildenafil Citrate (Viagra) Intake in a Nitrate-free Patient. Clin Cardiol. 1999;22(11):762-3. PubMed PMID: 10554698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute myocardial infarction following sildenafil citrate (Viagra) intake in a nitrate-free patient. AU - Porter,A, AU - Mager,A, AU - Birnbaum,Y, AU - Strasberg,B, AU - Sclarovsky,S, AU - Rechavia,E, PY - 1999/11/11/pubmed PY - 1999/11/11/medline PY - 1999/11/11/entrez SP - 762 EP - 3 JF - Clinical cardiology JO - Clin Cardiol VL - 22 IS - 11 N2 - Since its introduction to the market in March 1997, sildenafil acetate (Viagra) has been prescribed to 1.7 million people. Sixteen men who were taking the drug have died, 7 of them during or soon after sexual activity. Most of these data have been derived from the media and not from the scientific literature. There is a general impression that cardiovascular complications of sildenafil occur mainly when the drug is taken concomitantly with nitrates. We describe a 65-year-old man with known coronary artery disease who had an acute myocardial infarction shortly after taking sildenafil and engaging an sexual activity. The patient had not been using nitrates. We suggest that the emotional arousal induced by Viagra, followed by the heavy physical exertion during sexual activity, triggers plaque rupture that leads to acute myocardial infarction. SN - 0160-9289 UR - https://www.unboundmedicine.com/medline/citation/10554698/Acute_myocardial_infarction_following_sildenafil_citrate__Viagra__intake_in_a_nitrate_free_patient_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0160-9289&date=1999&volume=22&issue=11&spage=762 DB - PRIME DP - Unbound Medicine ER -