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Chronic myeloid leukemia from basics to bedside.

Abstract

The discovery of the Philadelphia chromosome and its consistent involvement in chronic myeloid leukemia (CML) was the first time that a relationship between a cytogenetic abnormality and malignancy was demonstrated. This review will try to provide an insight into the molecular mechanisms underlying this disease and outline the therapeutical options for patients with CML.

Authors+Show Affiliations

,

Department of Hematology, Br 250, University Hospital Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

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Source

Leukemia 13:11 1999 Nov pg 1646-74

MeSH

Bone Marrow Purging
Cell Transformation, Neoplastic
Cytogenetic Analysis
Fusion Proteins, bcr-abl
Genes, abl
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Philadelphia Chromosome
Signal Transduction

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10557038

Citation

Thijsen, S, et al. "Chronic Myeloid Leukemia From Basics to Bedside." Leukemia, vol. 13, no. 11, 1999, pp. 1646-74.
Thijsen S, Schuurhuis G, van Oostveen J, et al. Chronic myeloid leukemia from basics to bedside. Leukemia. 1999;13(11):1646-74.
Thijsen, S., Schuurhuis, G., van Oostveen, J., & Ossenkoppele, G. (1999). Chronic myeloid leukemia from basics to bedside. Leukemia, 13(11), pp. 1646-74.
Thijsen S, et al. Chronic Myeloid Leukemia From Basics to Bedside. Leukemia. 1999;13(11):1646-74. PubMed PMID: 10557038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic myeloid leukemia from basics to bedside. AU - Thijsen,S, AU - Schuurhuis,G, AU - van Oostveen,J, AU - Ossenkoppele,G, PY - 1999/11/11/pubmed PY - 1999/11/11/medline PY - 1999/11/11/entrez SP - 1646 EP - 74 JF - Leukemia JO - Leukemia VL - 13 IS - 11 N2 - The discovery of the Philadelphia chromosome and its consistent involvement in chronic myeloid leukemia (CML) was the first time that a relationship between a cytogenetic abnormality and malignancy was demonstrated. This review will try to provide an insight into the molecular mechanisms underlying this disease and outline the therapeutical options for patients with CML. SN - 0887-6924 UR - https://www.unboundmedicine.com/medline/citation/10557038/Chronic_myeloid_leukemia_from_basics_to_bedside_ L2 - http://www.diseaseinfosearch.org/result/1622 DB - PRIME DP - Unbound Medicine ER -