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Role of redox potential and reactive oxygen species in stress signaling.
Oncogene. 1999 Nov 01; 18(45):6104-11.O

Abstract

Stress-activated signaling cascades are affected by altered redox potential. Key contributors to altered redox potential are reactive oxygen species (ROS) which are formed, in most cases, by exogenous genotoxic agents including irradiation, inflammatory cytokines and chemical carcinogens. ROS and altered redox potential can be considered as the primary intracellular changes which regulate protein kinases, thereby serving as an important cellular component linking external stimuli with signal transduction in stress response. The mechanisms, which underlie the ROS-mediated response, involve direct alteration of kinases and transcription factors, and indirect modulation of cysteine-rich redox-sensitive proteins exemplified by thioredoxin and glutathione S-transferase. This review summarizes the current understanding of the mechanisms contributing to ROS-related changes in key stress activated signaling cascades.

Authors+Show Affiliations

Ruttenberg Cancer Center, Mount Sinai School of Medicine, 1 Gustave Levy Place, Box 1130, New York, NY 10029, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

10557101

Citation

Adler, V, et al. "Role of Redox Potential and Reactive Oxygen Species in Stress Signaling." Oncogene, vol. 18, no. 45, 1999, pp. 6104-11.
Adler V, Yin Z, Tew KD, et al. Role of redox potential and reactive oxygen species in stress signaling. Oncogene. 1999;18(45):6104-11.
Adler, V., Yin, Z., Tew, K. D., & Ronai, Z. (1999). Role of redox potential and reactive oxygen species in stress signaling. Oncogene, 18(45), 6104-11.
Adler V, et al. Role of Redox Potential and Reactive Oxygen Species in Stress Signaling. Oncogene. 1999 Nov 1;18(45):6104-11. PubMed PMID: 10557101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of redox potential and reactive oxygen species in stress signaling. AU - Adler,V, AU - Yin,Z, AU - Tew,K D, AU - Ronai,Z, PY - 1999/11/11/pubmed PY - 1999/11/11/medline PY - 1999/11/11/entrez SP - 6104 EP - 11 JF - Oncogene JO - Oncogene VL - 18 IS - 45 N2 - Stress-activated signaling cascades are affected by altered redox potential. Key contributors to altered redox potential are reactive oxygen species (ROS) which are formed, in most cases, by exogenous genotoxic agents including irradiation, inflammatory cytokines and chemical carcinogens. ROS and altered redox potential can be considered as the primary intracellular changes which regulate protein kinases, thereby serving as an important cellular component linking external stimuli with signal transduction in stress response. The mechanisms, which underlie the ROS-mediated response, involve direct alteration of kinases and transcription factors, and indirect modulation of cysteine-rich redox-sensitive proteins exemplified by thioredoxin and glutathione S-transferase. This review summarizes the current understanding of the mechanisms contributing to ROS-related changes in key stress activated signaling cascades. SN - 0950-9232 UR - https://www.unboundmedicine.com/medline/citation/10557101/Role_of_redox_potential_and_reactive_oxygen_species_in_stress_signaling_ L2 - https://doi.org/10.1038/sj.onc.1203128 DB - PRIME DP - Unbound Medicine ER -