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Evidence among blood donors for a 30-year-old epidemic of human T lymphotropic virus type II infection in the United States.
J Infect Dis. 1999 Dec; 180(6):1777-83.JI

Abstract

The demographic and geographic determinants of human T lymphotropic virus types I and II (HTLV-I and -II) are not well defined in the United States. Antibodies to HTLV-I and -II were measured in 1.7 million donors at five US blood centers during 1991-1995. Among those tested, 156 (9.1/10(5)) were HTLV-I seropositive and 384 (22.3/10(5)) were HTLV-II seropositive. In contrast to monotonously increasing age-specific HTLV-I seroprevalence, HTLV-II prevalence rose until age 40-49 years and declined thereafter, suggesting a birth cohort effect. HTLV-II infection was independently associated with an age of 40-49 years (odds ratio [OR], 12.4; 95% confidence interval [CI], 8.8-18.9), female sex (OR, 3.3; 95% CI, 2.6-4.1), high school or lower education (OR, 1.7; 95% CI, 1.3-2.1), hepatitis C seropositivity (OR, 25.0; 95% CI, 17.5-35.8), and first-time blood donation (OR, 3.6; 95% CI, 2.8-4.7). HTLV-II seroprevalence was highest at the two West Coast blood centers. These data are consistent with a 30-year-old epidemic of HTLV-II in the United States due to injection drug use and secondary sexual transmission and with an apparent West Coast focus.

Authors+Show Affiliations

Department of Laboratory Medicine, UCSF Box 0884, San Francisco, CA 94143, USA. murphy@labmed.ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10558931

Citation

Murphy, E L., et al. "Evidence Among Blood Donors for a 30-year-old Epidemic of Human T Lymphotropic Virus Type II Infection in the United States." The Journal of Infectious Diseases, vol. 180, no. 6, 1999, pp. 1777-83.
Murphy EL, Watanabe K, Nass CC, et al. Evidence among blood donors for a 30-year-old epidemic of human T lymphotropic virus type II infection in the United States. J Infect Dis. 1999;180(6):1777-83.
Murphy, E. L., Watanabe, K., Nass, C. C., Ownby, H., Williams, A., & Nemo, G. (1999). Evidence among blood donors for a 30-year-old epidemic of human T lymphotropic virus type II infection in the United States. The Journal of Infectious Diseases, 180(6), 1777-83.
Murphy EL, et al. Evidence Among Blood Donors for a 30-year-old Epidemic of Human T Lymphotropic Virus Type II Infection in the United States. J Infect Dis. 1999;180(6):1777-83. PubMed PMID: 10558931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence among blood donors for a 30-year-old epidemic of human T lymphotropic virus type II infection in the United States. AU - Murphy,E L, AU - Watanabe,K, AU - Nass,C C, AU - Ownby,H, AU - Williams,A, AU - Nemo,G, PY - 1999/11/24/pubmed PY - 2000/3/21/medline PY - 1999/11/24/entrez SP - 1777 EP - 83 JF - The Journal of infectious diseases JO - J Infect Dis VL - 180 IS - 6 N2 - The demographic and geographic determinants of human T lymphotropic virus types I and II (HTLV-I and -II) are not well defined in the United States. Antibodies to HTLV-I and -II were measured in 1.7 million donors at five US blood centers during 1991-1995. Among those tested, 156 (9.1/10(5)) were HTLV-I seropositive and 384 (22.3/10(5)) were HTLV-II seropositive. In contrast to monotonously increasing age-specific HTLV-I seroprevalence, HTLV-II prevalence rose until age 40-49 years and declined thereafter, suggesting a birth cohort effect. HTLV-II infection was independently associated with an age of 40-49 years (odds ratio [OR], 12.4; 95% confidence interval [CI], 8.8-18.9), female sex (OR, 3.3; 95% CI, 2.6-4.1), high school or lower education (OR, 1.7; 95% CI, 1.3-2.1), hepatitis C seropositivity (OR, 25.0; 95% CI, 17.5-35.8), and first-time blood donation (OR, 3.6; 95% CI, 2.8-4.7). HTLV-II seroprevalence was highest at the two West Coast blood centers. These data are consistent with a 30-year-old epidemic of HTLV-II in the United States due to injection drug use and secondary sexual transmission and with an apparent West Coast focus. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10558931/Evidence_among_blood_donors_for_a_30_year_old_epidemic_of_human_T_lymphotropic_virus_type_II_infection_in_the_United_States_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/315139 DB - PRIME DP - Unbound Medicine ER -