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Oncogenic role of Epstein-Barr virus-encoded RNAs in Burkitt's lymphoma cell line Akata.
J Virol 1999; 73(12):9827-31JV

Abstract

Our previous reports indicated that Epstein-Barr virus (EBV) contributes to the malignant phenotype and resistance to apoptosis in Burkitt's lymphoma (BL) cell line Akata (N. Shimizu, A. Tanabe-Tochikura, Y. Kuroiwa, and K. Takada, J. Virol. 68:6069-6073, 1994; J. Komano, M. Sugiura, and K. Takada, J. Virol. 72:9150-9156, 1998). Here we report that the EBV-encoded small RNAs (EBERs) are responsible for these phenotypes. Transfection of the EBER genes into EBV-negative Akata clones restored the capacity for growth in soft agar, tumorigenicity in SCID mice, resistance to apoptotic inducers, and upregulated expression of bcl-2 oncoprotein that were originally retained in parental EBV-positive Akata cells and lost in EBV-negative subclones. This is the first report which provides evidence that virus-encoded RNAs (EBERs) have oncogenic functions in BL cells.

Authors+Show Affiliations

Department of Virology, Cancer Institute, Hokkaido University School of Medicine, Kita-ku, Sapporo 060-8638, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10559294

Citation

Komano, J, et al. "Oncogenic Role of Epstein-Barr Virus-encoded RNAs in Burkitt's Lymphoma Cell Line Akata." Journal of Virology, vol. 73, no. 12, 1999, pp. 9827-31.
Komano J, Maruo S, Kurozumi K, et al. Oncogenic role of Epstein-Barr virus-encoded RNAs in Burkitt's lymphoma cell line Akata. J Virol. 1999;73(12):9827-31.
Komano, J., Maruo, S., Kurozumi, K., Oda, T., & Takada, K. (1999). Oncogenic role of Epstein-Barr virus-encoded RNAs in Burkitt's lymphoma cell line Akata. Journal of Virology, 73(12), pp. 9827-31.
Komano J, et al. Oncogenic Role of Epstein-Barr Virus-encoded RNAs in Burkitt's Lymphoma Cell Line Akata. J Virol. 1999;73(12):9827-31. PubMed PMID: 10559294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oncogenic role of Epstein-Barr virus-encoded RNAs in Burkitt's lymphoma cell line Akata. AU - Komano,J, AU - Maruo,S, AU - Kurozumi,K, AU - Oda,T, AU - Takada,K, PY - 1999/11/13/pubmed PY - 1999/11/13/medline PY - 1999/11/13/entrez SP - 9827 EP - 31 JF - Journal of virology JO - J. Virol. VL - 73 IS - 12 N2 - Our previous reports indicated that Epstein-Barr virus (EBV) contributes to the malignant phenotype and resistance to apoptosis in Burkitt's lymphoma (BL) cell line Akata (N. Shimizu, A. Tanabe-Tochikura, Y. Kuroiwa, and K. Takada, J. Virol. 68:6069-6073, 1994; J. Komano, M. Sugiura, and K. Takada, J. Virol. 72:9150-9156, 1998). Here we report that the EBV-encoded small RNAs (EBERs) are responsible for these phenotypes. Transfection of the EBER genes into EBV-negative Akata clones restored the capacity for growth in soft agar, tumorigenicity in SCID mice, resistance to apoptotic inducers, and upregulated expression of bcl-2 oncoprotein that were originally retained in parental EBV-positive Akata cells and lost in EBV-negative subclones. This is the first report which provides evidence that virus-encoded RNAs (EBERs) have oncogenic functions in BL cells. SN - 0022-538X UR - https://www.unboundmedicine.com/medline/citation/10559294/Oncogenic_role_of_Epstein_Barr_virus_encoded_RNAs_in_Burkitt's_lymphoma_cell_line_Akata_ L2 - http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=10559294 DB - PRIME DP - Unbound Medicine ER -