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The role of alcohol in the anti low density lipoprotein oxidation activity of red wine.
Atherosclerosis. 1999 Dec; 147(2):365-70.A

Abstract

Oxidation of low density lipoprotein cholesterol (LDL-c) is supposed to play a role in the generation of atherosclerotic lesions. Grape derived beverages supply a large number of nutritional antioxidants because of their high content of polyphenols. This might be one of the mechanisms behind the supposed beneficial effect of red wine. Wine also contains alcohol and its role in oxidation processes especially in vivo is unclear. In this study the effect of daily red wine consumption for 2 weeks on oxidizability status of LDL was investigated. The role of alcohol in LDL oxidation was further explored in in vitro experiments. After abstinence from alcoholic beverages, grape juices and tea for a week, seven healthy male volunteers consumed 375 ml of red wine (30 g alcohol) per day during 2 weeks. At the start and end of the drinking period blood samples were taken and the susceptibility of LDL-c to copper-induced oxidation was analyzed with the addition of distilled water (control) and dilutions of a 12% alcohol solution, white wine and red wine. Although red wine at concentrations achievable in vivo caused a significant prolongation of the lag-time of metal ion dependent LDL oxidation in vitro (85.9+/-23.0-114.1+/-30.8 min, P<0. 001), a significant shortening of lag-time was found in vivo after the 2 weeks of wine consumption (56.3+/-13.0 min, P<0.001). A shorter lag-time compared to the control was found for both alcohol and white wine in vitro. The changed oxidizability status of LDL after 2 weeks of wine consumption made it more susceptible for the in vitro antioxidant effect of red wine. At low dilutions red grape juice extended lag-time as well, which was not influenced by the addition of alcohol. Red wine has a strong inhibitory effect on copper-induced oxidation of LDL in vitro, while red grape juice has a minor effect, an effect which should be attributed to the non alcohol components in the beverages. In vivo, however, this effect can be overshadowed by the prooxidant influence of alcohol. The balance between alcohol and polyphenols of a wine may be critical for its in vivo effect on LDL oxidation.

Authors+Show Affiliations

Department of Internal Medicine, Eemland Hospital, PO Box 1502, 3800 BM, Amersfoort, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

10559522

Citation

van Golde, P H., et al. "The Role of Alcohol in the Anti Low Density Lipoprotein Oxidation Activity of Red Wine." Atherosclerosis, vol. 147, no. 2, 1999, pp. 365-70.
van Golde PH, Sloots LM, Vermeulen WP, et al. The role of alcohol in the anti low density lipoprotein oxidation activity of red wine. Atherosclerosis. 1999;147(2):365-70.
van Golde, P. H., Sloots, L. M., Vermeulen, W. P., Wielders, J. P., Hart, H. C., Bouma, B. N., & van de Wiel, A. (1999). The role of alcohol in the anti low density lipoprotein oxidation activity of red wine. Atherosclerosis, 147(2), 365-70.
van Golde PH, et al. The Role of Alcohol in the Anti Low Density Lipoprotein Oxidation Activity of Red Wine. Atherosclerosis. 1999;147(2):365-70. PubMed PMID: 10559522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of alcohol in the anti low density lipoprotein oxidation activity of red wine. AU - van Golde,P H, AU - Sloots,L M, AU - Vermeulen,W P, AU - Wielders,J P, AU - Hart,H C, AU - Bouma,B N, AU - van de Wiel,A, PY - 1999/11/24/pubmed PY - 1999/11/24/medline PY - 1999/11/24/entrez SP - 365 EP - 70 JF - Atherosclerosis JO - Atherosclerosis VL - 147 IS - 2 N2 - Oxidation of low density lipoprotein cholesterol (LDL-c) is supposed to play a role in the generation of atherosclerotic lesions. Grape derived beverages supply a large number of nutritional antioxidants because of their high content of polyphenols. This might be one of the mechanisms behind the supposed beneficial effect of red wine. Wine also contains alcohol and its role in oxidation processes especially in vivo is unclear. In this study the effect of daily red wine consumption for 2 weeks on oxidizability status of LDL was investigated. The role of alcohol in LDL oxidation was further explored in in vitro experiments. After abstinence from alcoholic beverages, grape juices and tea for a week, seven healthy male volunteers consumed 375 ml of red wine (30 g alcohol) per day during 2 weeks. At the start and end of the drinking period blood samples were taken and the susceptibility of LDL-c to copper-induced oxidation was analyzed with the addition of distilled water (control) and dilutions of a 12% alcohol solution, white wine and red wine. Although red wine at concentrations achievable in vivo caused a significant prolongation of the lag-time of metal ion dependent LDL oxidation in vitro (85.9+/-23.0-114.1+/-30.8 min, P<0. 001), a significant shortening of lag-time was found in vivo after the 2 weeks of wine consumption (56.3+/-13.0 min, P<0.001). A shorter lag-time compared to the control was found for both alcohol and white wine in vitro. The changed oxidizability status of LDL after 2 weeks of wine consumption made it more susceptible for the in vitro antioxidant effect of red wine. At low dilutions red grape juice extended lag-time as well, which was not influenced by the addition of alcohol. Red wine has a strong inhibitory effect on copper-induced oxidation of LDL in vitro, while red grape juice has a minor effect, an effect which should be attributed to the non alcohol components in the beverages. In vivo, however, this effect can be overshadowed by the prooxidant influence of alcohol. The balance between alcohol and polyphenols of a wine may be critical for its in vivo effect on LDL oxidation. SN - 0021-9150 UR - https://www.unboundmedicine.com/medline/citation/10559522/The_role_of_alcohol_in_the_anti_low_density_lipoprotein_oxidation_activity_of_red_wine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(99)00206-3 DB - PRIME DP - Unbound Medicine ER -