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The mechanical design of spider silks: from fibroin sequence to mechanical function.
J Exp Biol 1999; 202(Pt 23):3295-303JE

Abstract

Spiders produce a variety of silks, and the cloning of genes for silk fibroins reveals a clear link between protein sequence and structure-property relationships. The fibroins produced in the spider's major ampullate (MA) gland, which forms the dragline and web frame, contain multiple repeats of motifs that include an 8-10 residue long poly-alanine block and a 24-35 residue long glycine-rich block. When fibroins are spun into fibres, the poly-alanine blocks form (&bgr;)-sheet crystals that crosslink the fibroins into a polymer network with great stiffness, strength and toughness. As illustrated by a comparison of MA silks from Araneus diadematus and Nephila clavipes, variation in fibroin sequence and properties between spider species provides the opportunity to investigate the design of these remarkable biomaterials.

Authors+Show Affiliations

Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4. gosline@zoology.ubc.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

10562512

Citation

Gosline, J M., et al. "The Mechanical Design of Spider Silks: From Fibroin Sequence to Mechanical Function." The Journal of Experimental Biology, vol. 202, no. Pt 23, 1999, pp. 3295-303.
Gosline JM, Guerette PA, Ortlepp CS, et al. The mechanical design of spider silks: from fibroin sequence to mechanical function. J Exp Biol. 1999;202(Pt 23):3295-303.
Gosline, J. M., Guerette, P. A., Ortlepp, C. S., & Savage, K. N. (1999). The mechanical design of spider silks: from fibroin sequence to mechanical function. The Journal of Experimental Biology, 202(Pt 23), pp. 3295-303.
Gosline JM, et al. The Mechanical Design of Spider Silks: From Fibroin Sequence to Mechanical Function. J Exp Biol. 1999;202(Pt 23):3295-303. PubMed PMID: 10562512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The mechanical design of spider silks: from fibroin sequence to mechanical function. AU - Gosline,J M, AU - Guerette,P A, AU - Ortlepp,C S, AU - Savage,K N, PY - 1999/11/24/pubmed PY - 2000/2/19/medline PY - 1999/11/24/entrez SP - 3295 EP - 303 JF - The Journal of experimental biology JO - J. Exp. Biol. VL - 202 IS - Pt 23 N2 - Spiders produce a variety of silks, and the cloning of genes for silk fibroins reveals a clear link between protein sequence and structure-property relationships. The fibroins produced in the spider's major ampullate (MA) gland, which forms the dragline and web frame, contain multiple repeats of motifs that include an 8-10 residue long poly-alanine block and a 24-35 residue long glycine-rich block. When fibroins are spun into fibres, the poly-alanine blocks form (&bgr;)-sheet crystals that crosslink the fibroins into a polymer network with great stiffness, strength and toughness. As illustrated by a comparison of MA silks from Araneus diadematus and Nephila clavipes, variation in fibroin sequence and properties between spider species provides the opportunity to investigate the design of these remarkable biomaterials. SN - 0022-0949 UR - https://www.unboundmedicine.com/medline/citation/10562512/The_mechanical_design_of_spider_silks:_from_fibroin_sequence_to_mechanical_function_ L2 - http://jeb.biologists.org/cgi/pmidlookup?view=long&pmid=10562512 DB - PRIME DP - Unbound Medicine ER -