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Effect of coffee on gastro-oesophageal reflux in patients with reflux disease and healthy controls.
Eur J Gastroenterol Hepatol 1999; 11(11):1271-6EJ

Abstract

BACKGROUND

Many patients with gastro-oesophageal reflux disease (GORD) report that coffee aggravates their symptoms and doctors tend to discourage its use in GORD.

OBJECTIVE

To assess the effect of coffee ingestion on gastro-oesophageal acid reflux.

DESIGN

A randomized, controlled, crossover study.

PARTICIPANTS

Seven GORD patients and eight healthy subjects.

METHODS

After 1 day of coffee abstinence, participants underwent 24-h oesophageal pH and manometric monitoring. At well-defined times, they ingested either 280 ml of regular paper-filtered coffee or 280 ml of warm water. Coffee or water was drunk 1 h after breakfast, during lunch, 1 h after dinner and after an overnight fast Reflux and oesophageal motility parameters were assessed for the first hour after each coffee or water intake.

RESULTS

Coffee had no effect on postprandial acid reflux time or number of reflux episodes, either in GORD patients or in healthy subjects. Coffee increased the percentage acid reflux time only when ingested in the fasting period in the GORD patients (median 2.6, range 0-19.3 versus median 0, range 0-8.3; P = 0.028), but not in the healthy subjects. No effect of coffee on postprandial lower oesophageal sphincter pressure (LOSP), patterns of LOSP associated with reflux episodes or oesophageal contractions was found.

CONCLUSION

Coffee has no important effect on gastro-oesophageal acid reflux in GORD patients, and no effect at all in healthy subjects.

Authors+Show Affiliations

Department of Gastroenterology, University Medical Center, Utrecht, The Netherlands. pboekema@worldonline.nlNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10563539

Citation

Boekema, P J., et al. "Effect of Coffee On Gastro-oesophageal Reflux in Patients With Reflux Disease and Healthy Controls." European Journal of Gastroenterology & Hepatology, vol. 11, no. 11, 1999, pp. 1271-6.
Boekema PJ, Samsom M, Smout AJ. Effect of coffee on gastro-oesophageal reflux in patients with reflux disease and healthy controls. Eur J Gastroenterol Hepatol. 1999;11(11):1271-6.
Boekema, P. J., Samsom, M., & Smout, A. J. (1999). Effect of coffee on gastro-oesophageal reflux in patients with reflux disease and healthy controls. European Journal of Gastroenterology & Hepatology, 11(11), pp. 1271-6.
Boekema PJ, Samsom M, Smout AJ. Effect of Coffee On Gastro-oesophageal Reflux in Patients With Reflux Disease and Healthy Controls. Eur J Gastroenterol Hepatol. 1999;11(11):1271-6. PubMed PMID: 10563539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of coffee on gastro-oesophageal reflux in patients with reflux disease and healthy controls. AU - Boekema,P J, AU - Samsom,M, AU - Smout,A J, PY - 1999/11/24/pubmed PY - 1999/11/24/medline PY - 1999/11/24/entrez SP - 1271 EP - 6 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 11 IS - 11 N2 - BACKGROUND: Many patients with gastro-oesophageal reflux disease (GORD) report that coffee aggravates their symptoms and doctors tend to discourage its use in GORD. OBJECTIVE: To assess the effect of coffee ingestion on gastro-oesophageal acid reflux. DESIGN: A randomized, controlled, crossover study. PARTICIPANTS: Seven GORD patients and eight healthy subjects. METHODS: After 1 day of coffee abstinence, participants underwent 24-h oesophageal pH and manometric monitoring. At well-defined times, they ingested either 280 ml of regular paper-filtered coffee or 280 ml of warm water. Coffee or water was drunk 1 h after breakfast, during lunch, 1 h after dinner and after an overnight fast Reflux and oesophageal motility parameters were assessed for the first hour after each coffee or water intake. RESULTS: Coffee had no effect on postprandial acid reflux time or number of reflux episodes, either in GORD patients or in healthy subjects. Coffee increased the percentage acid reflux time only when ingested in the fasting period in the GORD patients (median 2.6, range 0-19.3 versus median 0, range 0-8.3; P = 0.028), but not in the healthy subjects. No effect of coffee on postprandial lower oesophageal sphincter pressure (LOSP), patterns of LOSP associated with reflux episodes or oesophageal contractions was found. CONCLUSION: Coffee has no important effect on gastro-oesophageal acid reflux in GORD patients, and no effect at all in healthy subjects. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/10563539/Effect_of_coffee_on_gastro_oesophageal_reflux_in_patients_with_reflux_disease_and_healthy_controls_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10563539.ui DB - PRIME DP - Unbound Medicine ER -