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Light-to-moderate alcohol consumption and the risk of stroke among U.S. male physicians.

Abstract

BACKGROUND

Several studies have shown U- or J-shaped relations between alcohol consumption and the risk of stroke. We evaluated the effect of light-to-moderate alcohol intake on the risk of stroke, with separate analyses of ischemic stroke and hemorrhagic stroke.

METHODS

Our analyses were based on a prospective cohort study of 22,071 male physicians, 40 to 84 years old, who were participating in the Physicians' Health Study. At base line, the participants reported that they had no history of stroke, transient ischemic attack, or myocardial infarction and were free of cancer. Alcohol intake, reported by 21,870 participants at base line, ranged from none or almost none to two or more drinks per day.

RESULTS

During an average of 12.2 years of follow-up, 679 strokes were reported. As compared with participants who had less than one drink per week, those who drank more had a reduced overall risk of stroke (relative risk, 0.79; 95 percent confidence interval, 0.66 to 0.94) and a reduced risk of ischemic stroke (relative risk, 0.77; 95 percent confidence interval, 0.63 to 0.94). There was no statistically significant association between alcohol consumption and hemorrhagic stroke. The overall relative risks of stroke for the men who had one drink per week, two to four drinks per week, five or six drinks per week, or one or more drinks per day were 0.78 (95 percent confidence interval, 0.59 to 1.04), 0.75 (95 percent confidence interval, 0.58 to 0.96), 0.83 (95 percent confidence interval, 0.62 to 1.11), and 0.80 (95 percent confidence interval, 0.64 to 0.99), respectively, in an analysis in which we controlled for major risk factors for stroke.

CONCLUSIONS

Light-to-moderate alcohol consumption reduced the overall risk of stroke and the risk of ischemic stroke in men. The benefit is apparent with as little as one drink per week. Greater consumption, up to one drink per day, does not increase the observed benefit.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.

    , , , , ,

    Source

    The New England journal of medicine 341:21 1999 11 18 pg 1557-64

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Alcohol Drinking
    Brain Ischemia
    Cerebral Hemorrhage
    Ethanol
    Exercise
    Humans
    Hypertension
    Male
    Middle Aged
    Physicians
    Prospective Studies
    Randomized Controlled Trials as Topic
    Risk Factors
    Stroke
    United States

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10564684

    Citation

    Berger, K, et al. "Light-to-moderate Alcohol Consumption and the Risk of Stroke Among U.S. Male Physicians." The New England Journal of Medicine, vol. 341, no. 21, 1999, pp. 1557-64.
    Berger K, Ajani UA, Kase CS, et al. Light-to-moderate alcohol consumption and the risk of stroke among U.S. male physicians. N Engl J Med. 1999;341(21):1557-64.
    Berger, K., Ajani, U. A., Kase, C. S., Gaziano, J. M., Buring, J. E., Glynn, R. J., & Hennekens, C. H. (1999). Light-to-moderate alcohol consumption and the risk of stroke among U.S. male physicians. The New England Journal of Medicine, 341(21), pp. 1557-64.
    Berger K, et al. Light-to-moderate Alcohol Consumption and the Risk of Stroke Among U.S. Male Physicians. N Engl J Med. 1999 11 18;341(21):1557-64. PubMed PMID: 10564684.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Light-to-moderate alcohol consumption and the risk of stroke among U.S. male physicians. AU - Berger,K, AU - Ajani,U A, AU - Kase,C S, AU - Gaziano,J M, AU - Buring,J E, AU - Glynn,R J, AU - Hennekens,C H, PY - 1999/11/24/pubmed PY - 2000/5/20/medline PY - 1999/11/24/entrez SP - 1557 EP - 64 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 341 IS - 21 N2 - BACKGROUND: Several studies have shown U- or J-shaped relations between alcohol consumption and the risk of stroke. We evaluated the effect of light-to-moderate alcohol intake on the risk of stroke, with separate analyses of ischemic stroke and hemorrhagic stroke. METHODS: Our analyses were based on a prospective cohort study of 22,071 male physicians, 40 to 84 years old, who were participating in the Physicians' Health Study. At base line, the participants reported that they had no history of stroke, transient ischemic attack, or myocardial infarction and were free of cancer. Alcohol intake, reported by 21,870 participants at base line, ranged from none or almost none to two or more drinks per day. RESULTS: During an average of 12.2 years of follow-up, 679 strokes were reported. As compared with participants who had less than one drink per week, those who drank more had a reduced overall risk of stroke (relative risk, 0.79; 95 percent confidence interval, 0.66 to 0.94) and a reduced risk of ischemic stroke (relative risk, 0.77; 95 percent confidence interval, 0.63 to 0.94). There was no statistically significant association between alcohol consumption and hemorrhagic stroke. The overall relative risks of stroke for the men who had one drink per week, two to four drinks per week, five or six drinks per week, or one or more drinks per day were 0.78 (95 percent confidence interval, 0.59 to 1.04), 0.75 (95 percent confidence interval, 0.58 to 0.96), 0.83 (95 percent confidence interval, 0.62 to 1.11), and 0.80 (95 percent confidence interval, 0.64 to 0.99), respectively, in an analysis in which we controlled for major risk factors for stroke. CONCLUSIONS: Light-to-moderate alcohol consumption reduced the overall risk of stroke and the risk of ischemic stroke in men. The benefit is apparent with as little as one drink per week. Greater consumption, up to one drink per day, does not increase the observed benefit. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/10564684/Light_to_moderate_alcohol_consumption_and_the_risk_of_stroke_among_U_S__male_physicians_ L2 - https://www.nejm.org/doi/10.1056/NEJM199911183412101?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=www.ncbi.nlm.nih.gov DB - PRIME DP - Unbound Medicine ER -